Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection

NARecruitingINTERVENTIONAL
Enrollment

1,040

Participants

Timeline

Start Date

September 29, 2022

Primary Completion Date

August 31, 2026

Study Completion Date

August 31, 2027

Conditions
Shiga Toxin-Producing Escherichia Coli (E. Coli) InfectionHemolytic-Uremic Syndrome
Interventions
OTHER

Infusion of 200% maintenance fluids as balanced crystalloid IV solution

Infusion of 200% of maintenance fluids x 24 hours provided, ideally, as a balanced crystalloid (PlasmaLyteTM, Ringer's Lactate) IV solution. Electrolytes and dextrose may be administered as required and desired by the clinical care team; customized solutions are permitted if so desired. Intravenous fluid solutions containing \< 130 mEq/L sodium may increase risk for hyponatremia and may be less effective in achieving intravascular volume expansion and should be avoided.

OTHER

Oral fluids; infusion of up to 110% maintenance fluids as balanced crystalloid IV solution

Administration of less than or equal to 110% of maintenance fluids as oral or balanced crystalloid IV solution.

Trial Locations (26)

20010

RECRUITING

Children's Research Institute, Washington D.C.

29425

RECRUITING

Medical University of South Carolina, Charleston

30322

RECRUITING

Emory University, Atlanta

35294

RECRUITING

University of Alabama at Birmingham, Birmingham

40202

RECRUITING

Norton Children's Hospital, Louisville

40526

RECRUITING

University of Kentucky, Lexington

43205

RECRUITING

Nationwide Children's Hospital, Columbus

RECRUITING

Vanderbilt Children's Hospital, Nashville

44106

RECRUITING

University Hospitals Rainbow Babies & Children's Hospital, Cleveland

47401

RECRUITING

Indiana University Children's Hospital, Indianapolis

55404

RECRUITING

Children's Minnesota Hospital, Minneapolis

63110

RECRUITING

Washington University, St Louis

72202

RECRUITING

Arkansas Children's Hospital, Little Rock

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

77030

RECRUITING

Baylor College of Medicine, Houston

80045

RECRUITING

University of Colorado Denver, Denver

84112

RECRUITING

University of Utah, Salt Lake City

92093

RECRUITING

University of California, San Diego, La Jolla

95817

RECRUITING

University of California, Davis, Sacramento

97239

RECRUITING

Oregon Health & Science University, Portland

98105

RECRUITING

Seattle Children's Hospital, Seattle

45229-3039

RECRUITING

Children's Hospital Medical Center, Cincinnati

T2N 1N4

RECRUITING

Alberta Children's Hospital, Calgary

T5J 4P6

RECRUITING

University of Alberta, Edmonton

L8S 4K1

RECRUITING

McMaster University, Hamilton

M5G 1X8

RECRUITING

The Hospital for Sick Children, Toronto

All Listed Sponsors
collaborator

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

collaborator

Children's Hospital Medical Center, Cincinnati

OTHER

collaborator

Washington University School of Medicine

OTHER

collaborator

University of Utah

OTHER

collaborator

Seattle Children's Hospital

OTHER

collaborator

University of Colorado, Denver

OTHER

collaborator

Emory University

OTHER

collaborator

University of California, Davis

OTHER

collaborator

Baylor College of Medicine

OTHER

collaborator

Indiana University School of Medicine

OTHER

collaborator

University of Alabama at Birmingham

OTHER

collaborator

Arkansas Children's Hospital Research Institute

OTHER

collaborator

Children's National Research Institute

OTHER

collaborator

Children's Hospitals and Clinics of Minnesota

OTHER

collaborator

Medical University of South Carolina

OTHER

collaborator

University of Louisville

OTHER

collaborator

University of Oklahoma

OTHER

collaborator

Oregon Health and Science University

OTHER

collaborator

University of California, San Diego

OTHER

collaborator

McMaster University

OTHER

collaborator

The Hospital for Sick Children

OTHER

collaborator

University of Alberta

OTHER

collaborator

University of Kentucky

OTHER

collaborator

Case Western Reserve University

OTHER

collaborator

Nationwide Children's Hospital

OTHER

collaborator

Vanderbilt University Medical Center

OTHER

lead

University of Calgary

OTHER