Understanding Disorder-specific Neural Pathophysiology in Laryngeal Dystonia and Voice Tremor

EARLY_PHASE1RecruitingINTERVENTIONAL
Enrollment

165

Participants

Timeline

Start Date

March 24, 2022

Primary Completion Date

August 31, 2026

Study Completion Date

August 31, 2026

Conditions
Laryngeal DystoniaSpasmodic DysphoniaTremor
Interventions
OTHER

Brain imaging

Brain images will be conducted with function MRI, magnetoencephalography (MEG), and electroencephalography (EEG) to identify disorder-specific neural markers

DRUG

Laryngeal sensory block with topical bupivacaine

Laryngeal sensory block with bupivacaine will be used to modulate sensory feedback from vocal fold mucosa and examine the impact of sensory feedback on abnormal neural activity in LD and VT

Trial Locations (1)

02114

RECRUITING

Massachusetts Eye and Ear and University of California San Francisco, Boston

All Listed Sponsors
collaborator

University of California, San Francisco

OTHER

lead

Massachusetts Eye and Ear Infirmary

OTHER