GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study

NARecruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

April 1, 2022

Primary Completion Date

April 30, 2026

Study Completion Date

April 30, 2027

Conditions
Cardiovascular DiseasesNatriuretic PeptidesCardiometabolic DiseasesEnergy ExpenditureGlucose MetabolismExerciseObesity
Interventions
DIETARY_SUPPLEMENT

Study diet

Participants will consume the study diet for 5 days provided by the clinical research unit's metabolic kitchen (at UAB)

OTHER

Exercise capacity VO2 max determination

Each participant's maximal oxygen capacity will be determined using a modified Bruce treadmill protocol and will also undergo a DEXA scan to determine the body mass.

OTHER

Exercise Challenge

Each participant will walk at 70 % of his/her VO2max for 20 minutes on treadmill and will also undergo a resting energy expenditure test.

OTHER

Glucose Challenge

Participants will come in fasting state on day 6th and will be given 75 gm oral glucose solution to drink, followed by blood collection every hour for next 8 hours.

Trial Locations (1)

35294

RECRUITING

University of Alabama at Birmingham, Birmingham

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

lead

University of Alabama at Birmingham

OTHER