Periodontal Health Status in Patients with Systemic Sclerosis

NARecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

February 5, 2019

Primary Completion Date

November 1, 2024

Study Completion Date

November 1, 2024

Conditions
Systemic SclerosisPeriodontitis
Interventions
PROCEDURE

periodontal examination's, determination of salivary antioxidants and cytokine levels (VEGF, TGF-β, Il-17) in gingival crevicular fluid, Non-surgical therapy of periodontitis

Periodontal parameters has been recorded on six sites of each tooth using a manual periodontal probe. Activity of antioxidants in unstimulated saliva (GPX, SOD, UA) has been determined using the colorimetric method and commercial kits. Total cytokine levels (VEGF, TGF-β, Il-17) in gingival crevicular fluid were determined using commercial ELISA (enzyme-linked immunosorbent assay) kits . The therapeutic procedure begun with ultrasonic scaling (MiniPiezon, EMS Electro Medical Systems, Switzerland), along with education and motivation of subjects to maintain oral hygiene properly. Periodontal debridement was carried out under local anesthesia, by quadrants, starting from the upper right quadrant at 7-day intervals until the completion of therapy. Instrumentation of all periodontal pockets was processed manually using specialized curettes.

DIAGNOSTIC_TEST

Activity of antioxidants in unstimulated saliva (GPX, SOD, UA)

Activity of antioxidants in unstimulated saliva (GPX, SOD, UA) has been determined using the colorimetric method and commercial kits.

DIAGNOSTIC_TEST

Total cytokine levels (VEGF, TGF-β, Il-17) in gingival crevicular fluid

Total cytokine levels (VEGF, TGF-β, Il-17) in gingival crevicular fluid were determined using commercial ELISA (enzyme-linked immunosorbent assay) kits .

PROCEDURE

Periodontal treatment

The therapeutic procedure begun with ultrasonic scaling (MiniPiezon, EMS Electro Medical Systems, Switzerland), along with education and motivation of subjects to maintain oral hygiene properly. Periodontal debridement was carried out under local anesthesia, by quadrants, starting from the upper right quadrant at 7-day intervals until the completion of therapy. Instrumentation of all periodontal pockets was processed manually using specialized curettes.

Trial Locations (1)

11000

RECRUITING

Department of Periodontology and Oral medicine, School of Dental Medicine, University of Belgrade, Belgrade

All Listed Sponsors
lead

University of Belgrade

OTHER