Acalabrutinib and Rituximab in Elderly Patients With Untreated Mantle Cell Lymphoma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

81

Participants

Timeline

Start Date

December 15, 2021

Primary Completion Date

January 31, 2027

Study Completion Date

January 31, 2027

Conditions
MCLMantle Cell Lymphoma
Interventions
DRUG

Acalabrutinib-rituximab in patients with untreated mantle cell lymphoma

Acalabrutinib, or ACP-196, is a next generation BTK inhibitor, more selective than ibrutinib, and without in vitro antagonism of anti-CD20 directed immunotherapies, indicating that its combination with rituximab may be more active than the combination of ibrutinib and rituximab

Trial Locations (20)

Unknown

Department of Hematology X, Odense University Hospital, Odense

Department of Hematology, Zeeland University Hospital Roskilde, Roskilde

Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki

Oulu University Hospital, Oulu

Department of Oncology, Haukeland University Hospital, Bergen

Avd. for Kreftbehandling, Oslo Universitetssykehus, Oslo

Avdeling for Blod- og Kreftsykdommer, Stavanger Universitetssykehus, Stavanger

Kreftklinikken, St Olavs Hospital, Trondheim

Division of Hematology-Oncology Samsung Medical Center Seoul, Seoul

Hematological Department, Falu Hospital, Falun, Falun

Department of Hematology and Coagulation, Sahlgrenska University Hospital, Gothenburg

Department of Medicine, Halmstad Country Hospital, Halmstad

Department of Internal Medicine, Kalmar County Hospital, Kalmar

Hematologiska Kliniken, Universitetssjukhuset, Linköping

Department of Medicine, Sunderbyn Hospital, Luleå

Mats Jerkeman, Lund

Center of Hematology, Karolinska University Hospital, Stockholm

Uddevalla Hospital, Uddevalla

Cancercentrum, Norrlands Universitetsjukhus, Umeå

Department of Oncology, Uppsala Academic Hospital, Uppsala

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

lead

Nordic Lymphoma Group

NETWORK