A Study to Determine Whether Chemotherapy and Atezolizumab is Better Than Chemotherapy, Bevacizumab and Atezolizumab in Patients With Advanced Liver Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

88

Participants

Timeline

Start Date

December 7, 2022

Primary Completion Date

March 31, 2026

Study Completion Date

March 31, 2026

Conditions
Combined Hepatocellular Carcinoma and CholangiocarcinomaStage III Liver CancerStage IV Liver Cancer
Interventions
BIOLOGICAL

Atezolizumab

Given IV

BIOLOGICAL

Bevacizumab

Given IV

PROCEDURE

Biospecimen Collection

Undergo blood specimen collection

DRUG

Cisplatin

Given IV

PROCEDURE

Computed Tomography

Undergo CT

PROCEDURE

Conventional Magnetic Resonance Imaging

Undergo MRI

DRUG

Gemcitabine Hydrochloride

Given IV

Trial Locations (37)

23235

VCU Massey Cancer Center at Stony Point, Richmond

23298

VCU Massey Comprehensive Cancer Center, Richmond

45331

Miami Valley Cancer Care and Infusion, Greenville

45373

Upper Valley Medical Center, Troy

45409

Miami Valley Hospital, Dayton

Premier Blood and Cancer Center, Dayton

45415

Miami Valley Hospital North, Dayton

45459

Miami Valley Hospital South, Centerville

46601

Memorial Hospital of South Bend, South Bend

50023

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny

50309

Iowa Methodist Medical Center, Des Moines

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

50314

Mercy Medical Center - Des Moines, Des Moines

54548

Marshfield Medical Center - Minocqua, Minocqua

54701

Marshfield Medical Center-EC Cancer Center, Eau Claire

61801

Carle Cancer Center, Urbana

The Carle Foundation Hospital, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62401

Carle Physician Group-Effingham, Effingham

75080

UT Southwestern Clinical Center at Richardson/Plano, Richardson

75235

Parkland Memorial Hospital, Dallas

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76104

UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth

94040

Palo Alto Medical Foundation-Camino Division, Mountain View

94086

Palo Alto Medical Foundation-Sunnyvale, Sunnyvale

94115

California Pacific Medical Center-Pacific Campus, San Francisco

94301

Palo Alto Medical Foundation Health Care, Palo Alto

94538

Palo Alto Medical Foundation-Fremont, Fremont

94589

Sutter Solano Medical Center/Cancer Center, Vallejo

94704

Alta Bates Summit Medical Center-Herrick Campus, Berkeley

95065

Palo Alto Medical Foundation-Santa Cruz, Santa Cruz

95355

Memorial Medical Center, Modesto

95602

Sutter Auburn Faith Hospital, Auburn

95661

Sutter Roseville Medical Center, Roseville

95816

Sutter Medical Center Sacramento, Sacramento

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH