442
Participants
Start Date
April 14, 2022
Primary Completion Date
July 31, 2025
Study Completion Date
September 30, 2026
CGT9486 plus sunitinib
Participants will receive both CGT9486 and sunitinib orally until study stopping rules are met.
CGT9486
Participants will receive CGT9486 until steady state then both CGT9486 and sunitinib orally until study stopping rules are met.
Sunitinib
Participants will receive sunitinib until steady state then both sunitinib and CGT9486 orally until study stopping rules are met.
Sunitinib
Participants will receive sunitinib orally until study stopping rules are met.
Midazolam
Participants will receive a single-dose of midazolam on Day 1 and Day 16
CGT9486 plus sunitinib
Patients will receive CGT9486 orally starting on Day 2 and sunitinib starting on Day 16 until study stopping rules are met.
Bankstown-Lidcombe Hospital, Bankstown
Debreceni Egyetem, Klinikai Központ, Onkológiai Klinika, Debrecen
Haukeland University Hospital - Bergen, Bergen
Sir Charles Gairdner Hospital, Nedlands
Aarhus University Hospital, Aarhus
National Taiwan University Hospital, New Taipei City
Memorial Sloan Kettering Cancer Center, New York
IRCCS La Fondazione e l'Istituto di Candiolo, Candiolo
National Cancer Center, Goyang-si
Taipei Veterans General Hospital (VGHTP), Taipei
AP-HM - Hôpital de la Timone, Marseille
Helios Klinikum Berlin-Buch, Berlin
Roswell Park Comprehensive Cancer Center, Buffalo
University of Pittsburgh Medical Center - Hillman Cancer Center, Pittsburgh
Helios Klinikum Bad Saarow, Bad Saarow
Hospital Clinico Universitario de Santiago de Compostela, Santiago de Compostela
Fox Chase Cancer Center, Philadelphia
MedStar Washington Hospital Center, Washington D.C.
Istituto Clinico Humanitas, Rozzano
Centro de Investigacion Medica Aquascalientes (CIMA), Aguascalientes
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
Istituto Europeo di Oncologia, Milan
Universitaetsklinikum Hamburg-Eppendorf, Hamburg
Skane University Hospital Lund, Lund
ASST degli Spedali Civili di Brescia, Brescia
Duke University, Durham
Hospital General Universitario Gregorio Maranon, Madrid
Hospital Clinico San Carlos, Madrid
Hospital Fundación Jiménez Díaz, Madrid
Hospital Universitario 12 de Octubre, Madrid
Hospital Clinico Universitario Virgen de la Arrixaca, El Palmar
Medizinische Hochschule Hannover- Urology Oncology, Hanover
CHU de Toulouse - Hospital Rangueil, Toulouse
Azienda Ospedaliera Universitaria Integrata Verona-Ospedale Borgo Trento, Verona
Mayo Clinic Jacksonville, Jacksonville
Mid Florida Hematology and Oncology Center, Orange City
Orlando Health Cancer Institute, Orlando
Institut Bergonie, Bordeaux
Centro Riferimento Oncologico - Aviano, Aviano
University of Miami - Sylvester Comprehensive Cancer Center, Miami
Chang Gung Memorial Hospital - Linkou Branch (CGMHLK), Taoyuan District
Moffitt Cancer Center, Tampa
Centre Eugene Marquis, Rennes
University of Alabama at Birmingham, Birmingham
Vanderbilt University Medical Center, Nashville
University of Tennessee, Knoxville
IRCCS Azienda Ospedaliero-Universitaria di Bologna - Policlinico di Sant'Orsola, Bologna
China Medical University Hospital, Taichung
Hospital Universitario Virgen del Rocio, Seville
The Ohio State University Comprehensive Cancer Center, Columbus
University of Toledo Medical Center, Toledo
The Cleveland Clinic Foundation, Cleveland
ICO St-Herblain, Saint-Herblain
Universitaetsklinikum Essen, Essen
"Istituto Romagnolo per lo Studio dei Tumori Dino Amadori", Meldola
University of Michigan Comprehensive Cancer Center, Ann Arbor
Hospital Universitario Miguel Servet, Zaragoza
Azienda Ospedaliero-Universitaria Careggi, Florence
University of Iowa Hospital and Clinics, Iowa City
University of Wisconsin - Carbone Cancer Center, Madison
Mayo Clinic, Rochester
Centre Oscar Lambret, Lille
Northwestern University, Chicago
Washington University, St Louis
I Can Oncology Center SA De CV, Monterrey
Masarykuv onkologicky ustav, Brno
University of Kansas Cancer Center, Kansas City
Oaxaca Site Management Organization S.C., Oaxaca City
Nebraska Methodist Hospital, Omaha
Universitaetsmedizin Mannheim, Mannheim
Centre Leon Berard, Lyon
Fakultni nemocnice Olomouc - Oncology clinic, Olomouc
University of Colorado Denver, Denver
Chang Gung Memorial Hospital - Kaohsiung Branch, Kaohsiung City
Mayo Clinic, Scottsdale
University of Arizona- Cancer Center, Tucson
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone, Palermo
University of California, Los Angeles (UCLA), Los Angeles
City of Hope, Duarte
University of California, San Diego (UCSD), San Diego
University of California, San Francisco, San Francisco
Gustave Roussy, Villejuif
Oregon Health & Science University (OHSU), Portland
Fred Hutchinson Cancer Center, Seattle
Instituto Oncologico FALP, Santiago
Centro de Oncologia de Precision, Universidad Mayor, Santiago
Dana-Farber Cancer Institute, Boston
The University of Texas MD Anderson Cancer Center, Houston
Instituto Alexander Fleming, Buenos Aires
Instituto Oncologico de Cordoba (IONC), Córdoba
Hospital das Clinicas da Universidade Estadual de Campinas (UNICAMP), Campinas
lnstituto Nacional de Cancer - INCA, Rio de Janeiro
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia, São Paulo
Alberta Health Services Cross Cancer Institute, Edmonton
Princess Margaret Hospital, Toronto
Tom Baker Cancer Center, Calgary
Universite de Montreal - Hopital Maisonneuve-Rosemont (HMR), Montreal
Fakultni nemocnice Hradec Kralove, Hradec Králové
Humanity & Health Clinical Trial Centre, Central
Hong Kong United Oncology Centre, Jordon
Prince of Wales Hospital, Shatin
Policlinico Universitario Campus Bio-Medico, Roma
Nederlands Kanker Instituut - Antoni van Leeuwenhoek Ziekenhuis (NKI-AVL), Amsterdam
UMC Groningen, Groningen
Stichting Radboud Universitair Medisch Centrum, Nijmegen
Erasmus MC, Rotterdam
Oslo University Hospital, Oslo
Szpital Specjalistyczny w Brzozowie, Brzozów
Centrum Onkologii im. Prof. Franciszka Lukaszczyka, Bydgoszcz
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy, Oddzial w Gliwicach, Oddzial Chemioterapii Dziennej, Gliwice
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy, Klinika Nowotworow Tkanek Miekkich, Kosci i Czerniakow, Warsaw
Seoul National University Hosptial, Seoul
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
Korea University Guro Hospital, Seoul
Hospital Universitario Vall d'Hebron, Barcelona
Hospital de la Santa Creu i Sant Pau Barcelona, Barcelona
Institut Catala d'Oncologia - L'Hospitalet, Barcelona
Karolinska University Hospital, Solna
Cambridge Addenbrooke's Hospital, Cambridge
Beatson, West of Scotland Cancer Centre, Glasgow
University College London Hospital, London
Guy's Hospital, London
Royal Marsden Hospital - Surrey, London
The Christie NHS Foundation Trust, Manchester
Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield
Lead Sponsor
Cogent Biosciences, Inc.
INDUSTRY