Molecular Imaging of Inflammation in Parkinson's Disease Using LPS and TSPO-PET/MR

RecruitingOBSERVATIONAL
Enrollment

30

Participants

Timeline

Start Date

February 28, 2022

Primary Completion Date

August 31, 2026

Study Completion Date

August 31, 2026

Conditions
Neurodegenerative DiseasesParkinson DiseaseREM Sleep Behavior Disorder (iRBD)
Interventions
DRUG

Lipopolysaccharide

All participants will receive one dose of Lipopolysaccharide (1ng/Kg) after the first PET/MR scan with \[11C\]PBR28 and four hours before the second PET/MR scan with \[11C\]PBR28.

RADIATION

PET/MR with [11C]PBR28

A PET/MR scan using the tracer \[11C\]PBR28 will be performed to all participants before and four hours after the administration of LPS

Trial Locations (1)

Unknown

RECRUITING

University of Exeter, Exeter

All Listed Sponsors
lead

University of Exeter

OTHER