Endometrial Cancer Patientes MMR Deficient Comparing Chemotherapy vs Dostarlimab in First Line

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

260

Participants

Timeline

Start Date

April 15, 2022

Primary Completion Date

April 30, 2026

Study Completion Date

October 31, 2029

Conditions
Endometrial Cancer
Interventions
DRUG

Carboplatin-Paclitaxel

Chemotherapy will be administered by intravenous infusion. Carboplatin AUC 5-6 + Pacltaxel 175 mg/m² every 3 weeks. Total duration of treatment: 6 cycles

DRUG

Dostarlimab

Dostarlimab will be administered through a 30-minute infusion at a dose of 500 mg Q3W from Cycle 1 through Cycle 4 and at a dose of 1,000 mg Q6W thereafter, beginning at Cycle 5 Day 1 up to a maximum of 2 years.

Trial Locations (100)

1023

Auckland City Hospital, Auckland

2298

Calvary Mater Newcastle, Waratah

2605

Canberra Hospital, Garran

3308

Centro di Riferimento Oncologico, Aviano

10408

National Cancer Center, Gyeonggi-do

13005

APHM - Hôpital de la Timone, Marseille

13273

Institut Paoli Calmettes, Marseille

13285

Hôpital Saint-Joseph, Marseille

13620

Seoul National University Bundang Hospital, Gyeonggi-do

13875

Ospedale degli Infermi, Biella

14000

Centre François Baclesse, Caen

14004

Hospital Universitario Reina Sofia, Córdoba

15706

Hospital Clínico Universitario Santiago de Compostela, Santiago de Compostela

20132

IRCCS Ospedale San Raffaele, Milan

20141

Istituto Europeo di Oncologia, Milan

21000

Centre Georges François Leclerc, Dijon

21079

Centre Hospitalier Intercommunal de Créteil, Créteil

CHU de Dijon, Dijon

22190

Centre CARIO - HPCA, Plérin

24008

Hospital Universitario de León, León

25000

CHRU Jean Minjoz, Besançon

25123

Spedali Civili-Università di Brescia, Brescia

27100

Fondazione IRCCS Policlinico San Matteo, Pavia

30029

Institut de cancérologie du gard, Nîmes

30203

Hospital General Universitario de Elche, Elche

31059

Institut Claudius Régaud - IUCT Oncopole, Toulouse

33076

Institut Bergonié, Bordeaux

33100

Azienda Sanitaria Universitaria Friuli Centrale, Udine

34298

ICM Val d'Aurelle, Montpellier

35042

Centre Eugène Marquis, Rennes

35760

Centre Hospitalier Privé de Saint-Grégoire, Saint-Grégoire

42055

CHU Saint-Etienne - Pôle de Cancérologie, Saint-Etienne

44000

Hôpital Privé du Confluent S.A.S., Nantes

44805

ICO - Centre René Gauducheau, Saint-Herblain

46026

Hospital Universitario y Politécnico La Fe, Valencia

48018

Ospedale Civile degli Infermi, Faenza

48022

"Ospedale Umberto I", Lugo

48121

"Ospedale Santa Maria delle Croci", Ravenna

49055

ICO Paul Papin, Angers

50009

Hospital Universitario Miguel Servet, Zaragoza

54511

ICL - Centre Alexis Vautrin, Vandœuvre-lès-Nancy

55100

Ospedale San Luca, Lucca

59020

Centre Oscar Lambret, Lille

60000

CH Simone Veil de Beauvais, Beauvais

60109

GHPSO, Creil

63000

Centre Jean Perrin, Clermont-Ferrand

64046

Centre Hospitalier Général de Pau, Pau

67200

Institut de Cancérologie de Strasbourg Europe - ICANS, Strasbourg

69310

Centre Hospitalier Lyon Sud, Lyon

69373

Centre Léon Bérard, Lyon

70124

IRCCS Istituto Oncologico Giovanni Paolo II, Bari

71100

Centre Hospitalier William Morey, Chalon-sur-Saône

72000

Clinique Victor Hugo, Le Mans

75005

Institut Curie, Paris

75013

AP-HP Hôpital Pitié-Salpêtrière, Paris

75014

Hôpital Cochin, Paris

75020

Groupe Hospitalier Diaconesses-Croix Saint-Simon, Paris

76038

Centre Henri Becquerel, Rouen

80054

CHU d'Amiens - Hôpital Sud, Amiens

80090

Clinique de l'Europe, Amiens

86021

CHU de Poitiers - Hôpital de la Milétrie, Poitiers

89011

Centre Hospitalier d'Auxerre, Auxerre

94805

Institut Gustave Roussy, Villejuif

119074

National University Hospital (NUH), Singapore

169610

National Cancer Centre Singapore (NCCS), Singapore

M5G2M9

Princess Margaret Cancer Centre, Toronto

Unknown

Institut Sainte Catherine, Avignon

CHU Brest, Brest

ROC 37, Chambray-lès-Tours

Hôpital de Mont-de-Marsan, Mont-de-Marsan

Médipôle de NANCY SAS, Nancy

CHU d'ORLEANS, Orléans

Hôpital Européen Georges Pompidou, Paris

Institut Mutualiste Montsouris, Paris

CHI de Cornouaille, Quimper

Institut Jean Godinot, Reims

CHU Strasbourg - Hôpital de Hautepierre, Strasbourg

CHU Bretonneau, Tours

06250

Centre Azuréen de Cancérologie, Mougins

06100

Centre Antoine Lacassagne, Nice

00161

Policlinco Umberto I, Roma

00168

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma

830-0011

Kurume University Hospital, Fukuoka

960-1295

Fukushima Medical University Hospital, Fukushima

135-8550

The Cancer Institute Hospital Of JFCR, Kōtoku

350-1298

Saitama Medical University International Medical Center, Saitama

03080

Seoul National University Hospital, Seoul

03722

Yonsei Medical Center Severance Hospital, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

08308

Korea University Guro Hospital, Seoul

08916

Hospital Germans Trias i Pujol / ICO Badalona, Badalona

07120

Hospital Universitario Son Espases, Palma

07198

Hospital Son Llátzer, Palma de Mallorca

B15 2GW GB

Queen Elizabeth Hospital, Birmingham

CB2 0QQ GB

Addenbrooke's Hospital, Cambridge

EH42XU

Western General Hospital, Edinburgh

NW1 2PG GB

University College London Hospital, London

NN1 5BD GB

Northampton General Hospital NHS Trust, Northampton

3LJ GB

Royal Cornwall Hospital, Truro

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

GlaxoSmithKline

INDUSTRY

lead

ARCAGY/ GINECO GROUP

OTHER

NCT05201547 - Endometrial Cancer Patientes MMR Deficient Comparing Chemotherapy vs Dostarlimab in First Line | Biotech Hunter | Biotech Hunter