Sotorasib and Panitumumab Versus Investigator's Choice for Participants With Kirsten Rat Sarcoma (KRAS) p.G12C Mutation

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

160

Participants

Timeline

Start Date

April 19, 2022

Primary Completion Date

July 16, 2025

Study Completion Date

December 31, 2025

Conditions
Colorectal Cancer (CRC)
Interventions
DRUG

Sotorasib

Sotorasib will be administered orally

DRUG

Panitumumab

Panitumumab will be administered as intravenous (IV) infusion

DRUG

Trifluridine and Tipiracil

Trifluridine and Tipiracil will be administered orally

DRUG

Regorafenib

Regorafenib will be administered orally

Trial Locations (105)

2050

Chris OBrien Lifehouse, Camperdown

2065

GenesisCare -North Shore (Oncology), St Leonards

2145

Westmead Hospital, Westmead

5011

The Queen Elizabeth Hospital, Woodville South

10002

National Taiwan University Hospital, Taipei

10601

White Plains Hospital Center for Cancer Care, White Plains

11217

Taipei Veterans General Hospital, Taipei

11527

General Hospital of Athens Laiko, Athens

11528

Evgenidio Hospital I Agia Trias, Athens

12100

Azienda Ospedaliera Santa Croce e Carle, Confreria (CN)

13210

Upstate University Hospital, Syracuse

13353

Charite Universitaetsmedizin Berlin, Charité Campus Virchow-Klinikum, Berlin

14004

Hospital Universitario Reina Sofia, Córdoba

15123

Hygeia Hospital, Athens

16132

Ospedale Policlinico San Martino IRCCS, Genova

17601

Lancaster General Hospital Ann B Barshinger Cancer Institute, Lancaster

18014

Hospital Universitario Virgen de las Nieves, Granada

19100

Azienda Sanitaria Locale 5 Spezzino Ospedale S Andrea, La Spezia

20016

Johns Hopkins University School of Medicine, Washington D.C.

20133

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

20162

Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan

25124

Istituto Ospedaliero Fondazione Poliambulanza, Brescia

26504

University Hospital of Patras, Pátrai

27403

Moses H Cone Memorial Hospital, Greensboro

28046

Hospital Universitario La Paz, Madrid

28100

Azienda Ospedaliero Universitaria Maggiore della Carita, Novara

30060

Northwest Georgia Oncology Centers PC, Marietta

31008

Hospital Universitario de Navarra, Pamplona

32005

Complexo Hospitalario Universitario de Ourense, Ourense

32256

Cancer Specialists of North Florida, Jacksonville

33014

Lakes Research LLC, Miami Lakes

33305

Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation, Taoyuan District

33604

Hôpital Haut -lévêque, Pessac

34298

Institut regional du Cancer Montpellier, Montpellier

35128

Istituto Oncologico Veneto IRCCS, Padua

35209

Central Alabama Research, Birmingham

36100

Azienda Unita Locale Socio Sanitaria Berica 8, Vicenza

37075

Universitaetsmedizin Goettingen - Georg-August-Universitaet, Göttingen

37203

Sarah Cannon Research Institute, Nashville

39008

Hospital Universitario Marques de Valdecilla, Santander

42100

Azienda Unita Sanitaria Locale di Reggio Emilia Arcispedale Santa Maria Nuova, Reggio Emilia

43210

The Mark H Zangmeister Center, Columbus

46014

Hospital General Universitario de Valencia, Valencia

48314

Revive Research Institute, Sterling Heights

48334

Revive Research Institute, Farmington Hills

48912

Sparrow Clinical Research Institute, Lansing

50134

Azienda Ospedaliera Universitaria Careggi, Florence

54007

Theagenion Anticancer Hospital, Thessaloniki

55236

Agios Loukas Clinic, Thessaloniki

56126

Azienda Ospedaliera Universitaria Pisana Ospedale Santa Chiara, Pisa

69437

Centre Hospitalier Universitaire de Lyon - Hopital Edouard Herriot, Lyon Cédex 3

70403

National Cheng Kung University Hospital, Tainan City

71500

University Hospital of Heraklion, Heraklion - Crete

72076

Universitaetsklinikum der Eberhard Karls Universitaet Tuebingen, Tübingen

73039

Azienda Ospedaliera Cardinale Giovanni Panico, Tricase

73100

Azienda Unita Sanitaria Locale LE Presidio Ospedaliero Vito Fazzi Polo Oncologico Giovanni Paolo II, Lecce

75015

Hôpital Européen Georges Pompidou, Paris

77025

Kelsey Research Foundation, Houston

77089

Best Cancer Care & Hematology, Houston

77339

Lumi Research, Kingwood

80131

Azienda Ospedaliero Universitaria Luigi Vanvitelli, Napoli

Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale, Napoli

80756

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

81377

Klinikum der Universitaet Muenchen Campus Grosshadern, München

85100

Azienda Ospedaliera San Carlo, Potenza

91010

City of Hope National Medical Center, Duarte

92868

University of California Irvine, Orange

95122

Azienda Ospedaliera Rilievo Nazionale e Alta Specializzazione Garibaldi Nesima, Catania

48106-0995

University of Michigan, Ann Arbor

01307

Universitaetsklinikum Carl Gustav Carus an der Technischen Universitaet Dresden, Dresden

09042

Azienda Ospedaliero Universitaria di Cagliari Policlinico Duilio Casula, Monserrato CA

00168

Policlinico Universitario Agostino Gemelli, Roma

00184

Azienda Ospedaliera San Giovanni Addolorata, Roma

00133

Fondazione Policlinico Tor Vergata, Roma (RM)

480-1195

Aichi Medical University Hospital, Nagakute-shi

260-8717

Chiba Cancer Center, Chiba

277-8577

National Cancer Center Hospital East, Kashiwa-shi

791-0280

National Hospital Organization Shikoku Cancer Center, Matsuyama

811-1395

National Hospital Organization Kyushu Cancer Center, Fukuoka

060-8648

Hokkaido University Hospital, Sapporo

673-8558

Hyogo Cancer Center, Akashi-shi

216-8511

St Marianna University Hospital, Kawasaki-shi

241-8515

Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center, Yokohama

540-0006

National Hospital Organization Osaka National Hospital, Osaka

565-0871

Osaka University Hospital, Suita-shi

362-0806

Saitama Cancer Center, Kitaadachi-gun

411-8777

Shizuoka Cancer Center, Sunto-gun

104-0045

National Cancer Center Hospital, Chuo-ku

135-8550

The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Koto-ku

03100

Health Pharma Professional Research SA de CV, Mexico City

06760

Superare Centro de Infusion SA de CV, Mexico City

06700

Trials In Medicine SC, Mexico City

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

08035

Hospital Universitari Vall d Hebron, Barcelona

08041

Hospital de la Santa Creu i Sant Pau, Barcelona

03203

Hospital General Universitario de Elche, Elche

G12 0YN

Beatson West of Scotland Cancer Centre, Glasgow

NW3 2QG

Royal Free Hospital, London

SW3 6JJ

Royal Marsden Hospital, London

ME16 9QQ

Maidstone Hospital, Maidstone

HA6 2RN

Mount Vernon Cancer Centre, Northwood

SM2 5PT

Royal Marsden Hospital, Sutton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY

NCT05198934 - Sotorasib and Panitumumab Versus Investigator's Choice for Participants With Kirsten Rat Sarcoma (KRAS) p.G12C Mutation | Biotech Hunter | Biotech Hunter