Testing the Addition of an Anti-Cancer Drug, TRC102, to the Usual Chemotherapy Treatment (Pemetrexed, Cisplatin or Carboplatin) During Radiation Therapy for Stage III Non-Squamous Non-Small Cell Lung Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

42

Participants

Timeline

Start Date

December 15, 2022

Primary Completion Date

June 30, 2027

Study Completion Date

June 30, 2027

Conditions
Lung AdenocarcinomaLung Large Cell CarcinomaLung Non-Squamous Non-Small Cell CarcinomaStage III Lung Cancer AJCC v8
Interventions
DRUG

Carboplatin

Given IV

DRUG

Cisplatin

Given IV

PROCEDURE

Computed Tomography

Undergo CT and FDG-PET/CT

BIOLOGICAL

Durvalumab

Given IV

PROCEDURE

FDG-Positron Emission Tomography

Undergo FDG-PET/CT

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

DRUG

Methoxyamine

Given PO

DRUG

Pemetrexed

Given IV

RADIATION

Radiation Therapy

Undergo thoracic radiation

Trial Locations (30)

10461

ACTIVE_NOT_RECRUITING

Montefiore Medical Center-Einstein Campus, The Bronx

10467

ACTIVE_NOT_RECRUITING

Montefiore Medical Center - Moses Campus, The Bronx

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

27157

RECRUITING

Wake Forest University Health Sciences, Winston-Salem

32610

RECRUITING

University of Florida Health Science Center - Gainesville, Gainesville

33136

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

RECRUITING

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33324

RECRUITING

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

RECRUITING

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

44106

RECRUITING

Case Western Reserve University, Cleveland

44109

RECRUITING

MetroHealth Medical Center, Cleveland

90033

RECRUITING

Los Angeles General Medical Center, Los Angeles

RECRUITING

USC / Norris Comprehensive Cancer Center, Los Angeles

90621

RECRUITING

Keck Medicine of USC Buena Park, Buena Park

91010

RECRUITING

City of Hope Comprehensive Cancer Center, Duarte

91030

RECRUITING

City of Hope South Pasadena, South Pasadena

91786

RECRUITING

City of Hope Upland, Upland

92618

RECRUITING

City of Hope at Irvine Lennar, Irvine

92663

RECRUITING

USC Norris Oncology/Hematology-Newport Beach, Newport Beach

93534

RECRUITING

City of Hope Antelope Valley, Lancaster

95817

RECRUITING

University of California Davis Comprehensive Cancer Center, Sacramento

07302

RECRUITING

Jersey City Medical Center, Jersey City

07039

RECRUITING

Saint Barnabas Medical Center, Livingston

07740

RECRUITING

Monmouth Medical Center, Long Branch

08903

RECRUITING

Rutgers Cancer Institute of New Jersey, New Brunswick

07112

RECRUITING

Newark Beth Israel Medical Center, Newark

08876

RECRUITING

Robert Wood Johnson University Hospital Somerset, Somerville

08755

RECRUITING

Community Medical Center, Toms River

77555-0565

RECRUITING

University of Texas Medical Branch, Galveston

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH