Study to Assess the Safety, Pharmacokinetics, and Efficacy of KPL-404 in Participants With Rheumatoid Arthritis With Inadequate Response or Intolerance to at Least One Biologic Disease-modifying Anti-rheumatic Drug or a Janus Kinase Inhibitor

PHASE2CompletedINTERVENTIONAL
Enrollment

145

Participants

Timeline

Start Date

December 14, 2021

Primary Completion Date

February 8, 2024

Study Completion Date

May 6, 2024

Conditions
Arthritis, Rheumatoid
Interventions
DRUG

KPL-404

Humanized monoclonal antibody

DRUG

Placebo

Matching placebo

Trial Locations (42)

1062

Magyar Honvedseg Egeszsegugyi Kozpont, Budapest

1619

Clinresco Centres (Pty) Ltd, Kempton Park

4002

"Medical center Artmed LTD", Plovdiv

4319

Umhlanga Hospital Medical Center, Umhlanga

4400

Szabolcs-Szatmar-Bereg Megyei Korhazak es Egyetemi Oktatokorhaz, Nyíregyháza

6725

Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont, Szeged

6800

Porcika Klinika, Hódmezővásárhely

7500

Panorama Medical Centre, Cape Town

8000

Vita Verum Medical Egeszsegugy, Székesfehérvár

16635

Altoona Center for Clinical Research, Duncansville

25801

Rheumatology and Pulmonary Clinic, Beckley

32117

International Medical Research, Daytona Beach

32174

Millennium Research, Ormond Beach

33014

San Marcus Research Clinic, Inc., Miami Lakes

33016

Sweet Hope Research Specialty, Inc., Hialeah

33321

West Broward Rheumatology Associates, Inc., Tamarac

38119

Saint Francis Hospital- Memphis, Memphis

44130

Paramount Medical Research & Consulting, LLC, Middleburg Heights

75007

Trinity Universal Research Assoc, Carrollton

75013

Arthritis and Rheumatology Research Institute, Allen

75150

Southwest Rheumatology Research LLC, Mesquite

77375

DM Clinical Research, Tomball

77377

Rheumatology Clinic of Houston, Tomball

78404

Arthritis & Osteoporosis Center of Coastal Bend, Corpus Christi

90602

Medvin Clinical Research, Whittier

91722

Medvin Clinical Research, Covina

91786

Inland Rheumatology Clinical Trials, Upland

92307

Carewell Arthritis Center, Apple Valley

702 00

Vesalion s.r.o., Ostrava

128 50

Revmatologicky Utsav, Prague

686 01

Medical Plus S.R.O., Uherské Hradiště

0102

Aleksandre Aladashvili Clinic LLC, Tbilisi

0112

LTD Israel-Georgian Medical Research Clinic Helsicore, Tbilisi

0159

JSC Evex Hospitals, Tbilisi

0172

LTD Georgian-Dutch Hospital, Tbilisi

1036-H

Qualiclinic Ltd (Qualiclinic Inc), Budapest

82-300

Centrum Kliniczno-Badawcze, Elblag

40-282

Silmedic sp. z o.o., Katowice

61-397

Prywatna Praktyka Lekarska Prof. UM dr hab.med. Pawel Hrycaj, Poznan

96-500

RCMed Oddzial Sochaczew, Sochaczew

Unknown

Centrum Medyczne Reuma Park, Warsaw

0002

Jacaranda Hospital, Pretoria

Sponsors
All Listed Sponsors
lead

Kiniksa Pharmaceuticals, Ltd.

INDUSTRY