NCT05194098View on ClinicalTrials.gov

Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression

NARecruitingINTERVENTIONAL
Enrollment

45

Participants

Timeline

Start Date

October 1, 2021

Primary Completion Date

September 30, 2024

Study Completion Date

September 30, 2024

Conditions
Major Depressive Disorder
Interventions
DEVICE

TMS: single session intermittent theta burst stimulation (iTBS) to dorsomedial prefrontal target in individuals with major depressive disorder, via MagVenture MagPro R30 device / Cool-DB80 A/P coil

Active Session: Single session of standard iTBS of 50Hz triplet bursts, 5 times each second with a 2 s on / 8 s off duty cycle for 600 pulses per hemisphere (1200 pulses total) will be applied for a total stimulation time of 6:40 minutes

DEVICE

SHAM (inactive) TMS stimulation

Sham neurostimulation (SHAM) entails use of the sham side of the D-B80 A/P placed over the same anatomical target, without any active stimulation.

Trial Locations (1)

94121

RECRUITING

San Francisco VA Medical Center, San Francisco

All Listed Sponsors
lead

San Francisco Veterans Affairs Medical Center

FED