GnRH Agonist Plus Hormone Replacement Therapy vs Hormone Replacement Therapy on IVF Outcomes

PHASE3CompletedINTERVENTIONAL
Enrollment

128

Participants

Timeline

Start Date

June 10, 2021

Primary Completion Date

January 3, 2022

Study Completion Date

January 3, 2022

Conditions
Polycystic Ovary SyndromeInfertility, Female
Interventions
DRUG

Long GnRH agonist + HRT

Intervention group:(Long GnRH agonist + HRT) From day 18-21 of the previous cycle, 0.5 cc of Superfect is injected daily and vaginal ultrasound is performed 10-14 days later If the endometrial thickness is less than 5 mm and there are no ovarian cysts, estradiol is started like HRT treatment and the agonist dose of GnRH starts with estradiol. It is halved (0.25 cc superfect) and superfect is prescribed until progesterone is started. At the time of progesterone administration, the administration of superfect is discontinued. Injections of estradiol and progesterone is the same as for the HRT group

DRUG

HRT

In the HRT group, from the second day of the cycle, the participant receives 2 mg of estradiol daily and this drug is increased to 6 mg per day in three days.Ten days later, they undergo vaginal ultrasound to check the thickness of the endometrium. If the thickness of the endometrium is greater than 8 mm, inject able progesterone is prescribed and the patient is a candidate for FET transfer. If the thickness is less than 7 mm, it is necessary to increase the dose of estradiol and continue treatment with it. The patient undergoes vaginal ultrasound every three days and if the desired thickness does not reach 21 days after the start of the cycle, the cycle is canceled

Trial Locations (1)

1653915981

Arash women's hospital,Tehran university of medical sciences, Tehran

All Listed Sponsors
lead

Tehran University of Medical Sciences

OTHER