Hormonal Monitoring and Progesterone Adjustment in Frozen Embryo Transfer Cycles

NACompletedINTERVENTIONAL
Enrollment

600

Participants

Timeline

Start Date

October 1, 2019

Primary Completion Date

March 15, 2021

Study Completion Date

October 1, 2021

Conditions
Female Infertility
Interventions
DRUG

estradiol valerate

8mg orally on daily basis for 13 days beginning with the first day of either a spontaneously or induced menstrual cycle then assess by ultrasound

OTHER

Hormonal monitoring progesterone, estradiol, luteinizing hormone

Serum Progesterone, estrogen \& LH measured on day 13 after priming endometrium with 8mg estradiol valerate on a daily basis beginning as early as the first day of menstrual cycle.

DIAGNOSTIC_TEST

transvaginal ultrasound examination

Patients examined using transvaginal ultrasonography on day 13 of exogenous estrogen supplementation to measure endometrial thickness and to detect signs of escape ovulation

DRUG

Progesterone 400 Mg Vaginal Suppository

Progesterone supplements given in form of daily two vaginal prontogest suppositories400 mg each

OTHER

Hormonal monitoring progesterone and estradiol

Measuring the serum Progesterone \& Estradiol in the early morning on the day of embryo transfer an progesterone supplementation adjusted as follows: Group II A: If P4 levels \< 5ng/dl, one 100 mg intramuscular injection daily added, Group II B: If P4 levels 5-10ng/dl, dydrogesterone three times daily added. Group II C: If P4 levels \>10ng, continued on 400 mg prontogest suppositories twice daily

DRUG

Progesterone

group II A: 100 mg intramuscular injection daily Group II B: If P4 levels 5-10ng/dl dydrogesterone added

Trial Locations (1)

Unknown

Infertility Center, Alexandria

All Listed Sponsors
lead

Alexandria University

OTHER

NCT05189145 - Hormonal Monitoring and Progesterone Adjustment in Frozen Embryo Transfer Cycles | Biotech Hunter | Biotech Hunter