600
Participants
Start Date
October 1, 2019
Primary Completion Date
March 15, 2021
Study Completion Date
October 1, 2021
estradiol valerate
8mg orally on daily basis for 13 days beginning with the first day of either a spontaneously or induced menstrual cycle then assess by ultrasound
Hormonal monitoring progesterone, estradiol, luteinizing hormone
Serum Progesterone, estrogen \& LH measured on day 13 after priming endometrium with 8mg estradiol valerate on a daily basis beginning as early as the first day of menstrual cycle.
transvaginal ultrasound examination
Patients examined using transvaginal ultrasonography on day 13 of exogenous estrogen supplementation to measure endometrial thickness and to detect signs of escape ovulation
Progesterone 400 Mg Vaginal Suppository
Progesterone supplements given in form of daily two vaginal prontogest suppositories400 mg each
Hormonal monitoring progesterone and estradiol
Measuring the serum Progesterone \& Estradiol in the early morning on the day of embryo transfer an progesterone supplementation adjusted as follows: Group II A: If P4 levels \< 5ng/dl, one 100 mg intramuscular injection daily added, Group II B: If P4 levels 5-10ng/dl, dydrogesterone three times daily added. Group II C: If P4 levels \>10ng, continued on 400 mg prontogest suppositories twice daily
Progesterone
group II A: 100 mg intramuscular injection daily Group II B: If P4 levels 5-10ng/dl dydrogesterone added
Infertility Center, Alexandria
Alexandria University
OTHER