Lung Ultrasound-Guided Fluid Deresuscitation in ICU Patients

NARecruitingINTERVENTIONAL
Enrollment

1,000

Participants

Timeline

Start Date

December 22, 2021

Primary Completion Date

July 1, 2025

Study Completion Date

December 1, 2025

Conditions
Mechanical VentilationFluid OverloadDeresuscitationVentilator-free Days
Interventions
OTHER

Lung ultrasound guided deresuscitation

"With every new LUS examination, the following scenarios, with distinct recommendations, are possible:~1. LUS observations suggest massive pulmonary fluid overload, with the recommendation to minimize fluid infusion and start fluid withdrawal, targeting a negative fluid balance of at least -1500 ml in the next 24 hours;~2. LUS suggests some pulmonary edema and/or significant pleural effusion. These LUS observations suggest little pulmonary fluid overload, with the suggestion to minimize fluid infusion and start fluid withdrawal, targeting a negative fluid balance at least -500 ml in the next 24 hours;~3. LUS suggests absence of pulmonary edema and no pleural effusion. These LUS observations suggest no fluid overload, with the suggestion to target a neutral fluid balance in the next 24 hours."

Trial Locations (3)

6800 TA

RECRUITING

Rijnstate, Arnhem

1081 HV

RECRUITING

Amsterdam UMC, location VUMC, Amsterdam

1105AZ

RECRUITING

Amsterdam UMC, location AMC, Amsterdam

All Listed Sponsors
collaborator

ZonMw: The Netherlands Organisation for Health Research and Development

OTHER

lead

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

OTHER