Long-Term Effects of Repetitive, Low-Level Blast Exposure on Special Operations Forces Service Members

CompletedOBSERVATIONAL
Enrollment

30

Participants

Timeline

Start Date

July 1, 2021

Primary Completion Date

February 28, 2023

Study Completion Date

February 28, 2023

Conditions
Traumatic Brain InjuryBlast Injuries
Interventions
DIAGNOSTIC_TEST

3T Connectome MRI

MRI scan of structural connectivity

DIAGNOSTIC_TEST

7 Tesla MRI

MRI scan of functional connectivity

DIAGNOSTIC_TEST

TSPO PET

PET scan of neuroinflammation

DIAGNOSTIC_TEST

Tau PET

PET scan of tau deposition

DIAGNOSTIC_TEST

Cognitive and Behavioral Assessments

Assessments of memory, attention, complex reasoning, mood and other cognitive/behavioral domains

DIAGNOSTIC_TEST

Blood Biomarkers

Blood-based assessments of proteomic and metabolic biomarkers of brain injury

Trial Locations (1)

02114

Massachusetts General Hospital, Boston

All Listed Sponsors
lead

Massachusetts General Hospital

OTHER