Study Evaluating Combination of Luspatercept in LR-MDS Without RS Having Failed or Being Ineligible to ESA

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

150

Participants

Timeline

Start Date

May 18, 2022

Primary Completion Date

December 19, 2028

Study Completion Date

June 19, 2029

Conditions
MDSMyelodysplastic Syndromes
Interventions
DRUG

Luspatercept Injection [Reblozyl]

All patients will receive Luspatercept subcutaneously on day 1 of each 21 day cycle (every 3 weeks) at the selected dose according to part A : 1.75mg/kg or 1.33 mg/kg or 0.8 mg/kg

DRUG

Eprex

Epoietin alfa will be adminstered as a subcutaneous injection at the selected dose according to part A : 30 000 UI/week or 60 000 UI/week, every week

Trial Locations (38)

24019

RECRUITING

Centre Hospitalier de Périgueux, Périgueux

26000

RECRUITING

Centre Hospitalier de Valence, Valence

29107

NOT_YET_RECRUITING

Centre Hospitalier de Cornouaille, Quimper

30029

RECRUITING

CHU de Nîmes, Nîmes

31059

RECRUITING

CHU Toulouse - IUCT Oncopole, Toulouse

33604

RECRUITING

CHU de Bordeaux - Hôpital Haut-Lévêque, Pessac

34295

RECRUITING

CHU Saint Eloi, Montpellier

35033

RECRUITING

CHU de Rennes - Hôpital Pontchaillou, Rennes

35510

RECRUITING

Hôpital Privé Sévigné, Cesson-Sévigné

37000

RECRUITING

CHU de Tours - Hôpital Bretonneau, Tours

38043

RECRUITING

CHU de Grenoble, Grenoble

40000

NOT_YET_RECRUITING

Centre Hospitalier de Mont de Marsan, Mont-de-Marsan

42271

NOT_YET_RECRUITING

Institut de Cancérologie et d'Hématologie Universitaire de Saint-Etienne, Saint-Priest-en-Jarez

44093

RECRUITING

CHU Nantes - Hôtel Dieu, Nantes

44277

NOT_YET_RECRUITING

Hôpital privé du Confluent, Nantes

45067

RECRUITING

CHR d'Orléans, Orléans

49933

RECRUITING

CHU Angers, Angers

54511

RECRUITING

CHRU Nancy - Hôpitaux de Brabois, Vandœuvre-lès-Nancy

59037

NOT_YET_RECRUITING

CHRU de Lille - Hôpital Claude Huriez, Lille

64109

NOT_YET_RECRUITING

Centre Hospitalier de la Côte Basque, Bayonne

67000

NOT_YET_RECRUITING

Strasbourg Oncologie Libérale Clinique Sainte Anne, Strasbourg

69495

NOT_YET_RECRUITING

Centre Hospitalier Lyon Sud, Pierre-Bénite

72037

RECRUITING

CH Le Mans, Le Mans

75010

RECRUITING

Hôpital Saint Louis, Paris

75014

NOT_YET_RECRUITING

Hôpital Cochin, Paris

75015

RECRUITING

Hôpital Necker, Paris

76038

RECRUITING

Centre Henri Becquerel, Rouen

78150

NOT_YET_RECRUITING

Centre Hospitalier de Versailles, Le Chesnay

80054

RECRUITING

CHU Amiens-Picardie, Amiens

80090

NOT_YET_RECRUITING

Clinique de l'Europe, Amiens

84000

RECRUITING

CH Henri Duffaut d'Avignon, Avignon

86021

NOT_YET_RECRUITING

CHU de Poitiers, Poitiers

87042

NOT_YET_RECRUITING

CHRU de Limoges - Hôpital Dupuytren, Limoges

93009

NOT_YET_RECRUITING

Hôpital Avicenne, Bobigny

94270

RECRUITING

Hôpital Bicêtre, Le Kremlin-Bicêtre

95107

RECRUITING

Centre Hospitalier Victor Dupouy, Argenteuil

95300

NOT_YET_RECRUITING

Hôpital NOVO, Pontoise

06202

RECRUITING

CHU de Nice - Hôpital Archet 1, Nice

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Celgene

INDUSTRY

lead

Groupe Francophone des Myelodysplasies

OTHER