250
Participants
Start Date
July 27, 2022
Primary Completion Date
June 30, 2026
Study Completion Date
December 31, 2028
Bromocriptine
Bromocriptine 2.5 mg one tablet by mouth twice daily for 2 weeks then once daily for 6 weeks. Subjects not on anticoagulation at the time of entry will also receive rivaroxaban 10 mg tablets once daily for 8 weeks while on bromocriptine.
Placebo
Placebo one tablet by mouth twice daily for 2 weeks then once daily for 6 weeks. Subjects who are not on anticoagulation will not receive rivaroxaban but will receive a second placebo once daily for 8 weeks while on study drug.
Guideline Directed Medical Therapy for Heart Failure (GDMT)
GDMT will potentially include angiotensin converting enzyme inhibitors (ACEi), angiotensin II receptor antagonists (ARB), angiotensin receptor blocker-neprilysin inhibitors (ARNI), beta adrenergic receptor antagonists (beta blockers) , Mineralocorticoid receptor antagonists (MRA), sodium-glucose cotransporter-2 inhibitors (SGLT2i),
Rivaroxaban
Subjects not on anticoagulation clinically who are randomized to bromocriptine will receive rivaroxaban 10 mg tablets once tablet by mouth daily for 8 weeks while on bromocriptine.
Second Placebo
Subjects not on anticoagulation clinically who are randomized to placebo (rather than bromocriptine) will receive a second placebo one tablet by mouth daily for 8 weeks.
RECRUITING
NYU Langone Health, New York
RECRUITING
Mount Sinai Hospital, New York
RECRUITING
Columbia University Irving Medical Center, New York
RECRUITING
Albert Einstein College of Medicine/ Montefiore Medical Center, The Bronx
RECRUITING
Stony Brook Medicine, Stony Brook
RECRUITING
University of Rochester, Rochester
RECRUITING
University of Pittsburgh Medical Center, Pittsburgh
RECRUITING
Penn State Hershey Medical Center, Hershey
WITHDRAWN
Lehigh Valley Health Network, Allentown
RECRUITING
University of Pennsylvania, Philadelphia
RECRUITING
Temple Heart and Vascular Institute, Philadelphia
RECRUITING
University of Maryland Medical Center, Baltimore, Baltimore
RECRUITING
Johns Hopkins University, Baltimore
RECRUITING
Inova Healthcare Services, Fairfax
RECRUITING
University of Virginia, Charlottesville
RECRUITING
Virginia Commonwealth University, Richmond
RECRUITING
Old Dominion University, Norfolk
RECRUITING
Atrium Health Sanger Heart and Vascular Institute, Charlotte
RECRUITING
Medical University of South Carolina, Charleston
RECRUITING
Emory University, Atlanta
RECRUITING
Mayo Clinic, Florida, Jacksonville
RECRUITING
University of Florida, Gainesville
RECRUITING
University of South Florida, Tampa
RECRUITING
University of Alabama Birmingham, Birmingham
RECRUITING
Vanderbilt, Nashville
RECRUITING
Stern Cardiovascular Foundation, Inc, Germantown
RECRUITING
University of Kentucky, Gill Heart & Vascular Institute, Lexington
RECRUITING
University Hospitals, Cleveland Medical Center, Cleveland
RECRUITING
Cleveland Clinic, Cleveland
RECRUITING
Indiana University/Indiana University Health, Indianapolis
RECRUITING
Ascension St. Vincent Heart Center, Indianapolis
RECRUITING
University of Michigan, Ann Arbor
RECRUITING
Henry Ford Health System, Detroit
RECRUITING
University of Iowa Hospitals and Clinic, Iowa City
RECRUITING
Medical College of Wisconsin, Milwaukee
RECRUITING
University of Wisconsin Madison, Madison
RECRUITING
Minneapolis Heart Institute Foundation, Minneapolis
RECRUITING
University of Minnesota, Minneapolis
RECRUITING
Mayo Clinic, Rochester, Rochester
RECRUITING
Northwestern University, Chicago
RECRUITING
University of Illinois Health Heart Center, Chicago
RECRUITING
Washington University School of Medicine, St Louis
RECRUITING
Saint Luke's Hospital of Kansas City, Kansas City
RECRUITING
Karen L Florio, MD, Columbia
RECRUITING
Louisiana State University, Shreveport
RECRUITING
Oklahoma university Health Science Center, Oklahoma City
RECRUITING
Baylor College of Medicine, Houston
WITHDRAWN
University of Texas Health San Antonio, San Antonio
RECRUITING
University of Colorado Anschutz Medical Campus, Aurora
RECRUITING
Intermountain Medical Center, Murray
RECRUITING
University of Arizona Sarver Heart Center, Tucson
RECRUITING
Keck School of Medicine of USC, Los Angeles
RECRUITING
Cedars-Sinai Medical Center, Los Angeles
RECRUITING
University of California Irvine Health, Orange
RECRUITING
Stanford University, Stanford
RECRUITING
University of Washington Medical Center, Seattle
RECRUITING
University of California San Diego, La Jolla
RECRUITING
Hartford Hospital, Hartford
RECRUITING
Yale University, New Haven
RECRUITING
Massachusetts General Hospital, Boston
RECRUITING
Brigham and Women's Hospital, Boston
RECRUITING
Rhode Island Hospital, Providence
WITHDRAWN
UT Southern Medical Center, Dallas
RECRUITING
University of Vermont Medical Center, Burlington
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Dennis M. McNamara, MD, MS
OTHER