GEN1047 for Solid Tumors - First in Human (FIH) Trial

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

179

Participants

Timeline

Start Date

December 13, 2021

Primary Completion Date

March 26, 2026

Study Completion Date

March 26, 2026

Conditions
Breast Cancer, Breast NeoplasmsEndometrial Cancer, Endometrial NeoplasmOvarian Cancer, Ovarian NeoplasmsSquamous Non Small Cell Lung Cancer (NSCLC-SCC)
Interventions
BIOLOGICAL

GEN1047 is a bispecific antibody that induces T-cell mediated cytotoxicity of B7H4-positive tumor cells.

GEN1047 will be administered as an intravenous infusion. The dose-levels will be determined by the starting dose and the escalation steps taken in the trial.

Trial Locations (36)

435

IEO Istituto Europeo di Oncologia, Milan

2100

Rigshospitalet (Copenhagen University Hospital), Copenhagen

2650

Antwerp University Hospital, Edegem

2815

Hospital Universitary Fundacion Jimenez Diaz, Madrid

3000

Universitair Ziekenhuis Leuven, Leuven

8035

Hospital Universitari Vall d'Hebron, Barcelona

19104

University of Pennsylvania, Philadelphia

20900

Fondazione IRCCS San Gerardo dei Tintori, Monza

25030

CHU de Besancon, Besançon

28033

MD Anderson Cancer Center, Madrid

28034

Hospital Ruber Internacional, Madrid

28050

Centro Oncologico Clara Campal, Madrid

31008

Clinica Universidad de Navarra, Pamplona

34298

Institut du Cancer de Montpellier, Montpellier

37203

Sarah Cannon Research Institute, Nashville

44106

Case Western Reserve University, Cleveland

48201

Barbara Ann Karmanos Cancer Institute, Detroit

69008

Centre Léon Bérard, Lyon

75005

Institut Gustave Roussy, Villejuif

75248

Institut Curie, Paris

90024

UCLA Department of Medicine Hematology Oncology, Los Angeles

06520-8028

Yale University - Yale Cancer Center, New Haven

Unknown

Institut Bergonié, Bordeaux

Hôpital Cochin, Paris

CHU Poitiers - Hôpital la Milétrie, Poitiers

Institut Claudius Regaud, Toulouse

Med-Polonia Sp. z o.o, Poznan

Hospital Clinic de Barcelona, Barcelona

NEXT Oncology Madrid, Madrid

Hospital Clinico Universitario de Valencia, Valencia

9713GZ

University Medical Center Groningen, Groningen

6525GA

Radboudumc, Nijmegen

3015CE

Erasmus Medisch Centrum, Rotterdam

EC1A7BE

St Bartholomews Hospital, London

NW1 2BU

University College London Hospital, London

M20 4BX

The Christie Hospital, Manchester

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Genmab

INDUSTRY

NCT05180474 - GEN1047 for Solid Tumors - First in Human (FIH) Trial | Biotech Hunter | Biotech Hunter