PROfiling Based Endometrial Cancer Adjuvant Therapy

NARecruitingINTERVENTIONAL
Enrollment

590

Participants

Timeline

Start Date

January 24, 2022

Primary Completion Date

December 31, 2026

Study Completion Date

January 1, 2027

Conditions
Endometrial Cancer Stage IEndometrial Cancer Stage II
Interventions
RADIATION

Vaginal brachytherapy

"Internal radiation of the vaginal vault using a vaginal cylinder. For brachytherapy administered alone it is recommended: suggested dose is either 3 fractions of 7 Gy or 5 fractions of 6 Gy.~For brachytherapy administered after completion of External beam radiotherapy (EBRT):~Total dose should aim to be 65 Gy, and suggested dose is 2-3 fractions of 5-6 Gy"

RADIATION

External beam radiotherapy

External beam pelvic radiotherapy on a linear accelerator, 45-50 Gy in 25-28 out-patients sessions

OTHER

Observation

No adjuvant therapy, but active follow-up and quality of life questionnaires as in the groups who have adjuvant treatment

COMBINATION_PRODUCT

Chemoradiation therapy

4 adjuvant cycles carboplatin and paclitaxel followed by External beam pelvic radiotherapy (45-50 Gy )

Trial Locations (10)

310000

RECRUITING

Women's Hospital School of Medicine Zhejiang University, Hangzhou

Unknown

RECRUITING

Tongji Hospital, Huazhong University of Science and Technology, Wuhan

RECRUITING

Qilu Hospital of Shandong University, Jinan

NOT_YET_RECRUITING

Peking University Peoples Hospital, Beijing

RECRUITING

Xiangya Hospital of Central South University, Changsha

NOT_YET_RECRUITING

Sun Yat-Sen University Cancer Hospital, Guangzhou

RECRUITING

Ningbo First Hospital, Ningbo

RECRUITING

Ningbo Women and Children's Hospital, Ningbo

NOT_YET_RECRUITING

Obstetrics & Gynecology Hospital of Fudan University, Shanghai

NOT_YET_RECRUITING

Shanghai First Maternity and Infant Hospital, Shanghai

All Listed Sponsors
collaborator

Tongji Hospital

OTHER

collaborator

Qilu Hospital of Shandong University

OTHER

collaborator

Obstetrics & Gynecology Hospital of Fudan University

OTHER

collaborator

Sun Yat-sen University

OTHER

collaborator

Peking University People's Hospital

OTHER

collaborator

Shanghai First Maternity and Infant Hospital

OTHER

collaborator

Xiangya Hospital of Central South University

OTHER

collaborator

Anhui Provincial Cancer Hospital

OTHER

collaborator

Ningbo Women & Children's Hospital

OTHER

collaborator

Ningbo No. 1 Hospital

OTHER

lead

Women's Hospital School Of Medicine Zhejiang University

OTHER