Evaluating the Neurocomputational Mechanisms of Explore-Exploit Decision Making in Older Adults

NACompletedINTERVENTIONAL
Enrollment

248

Participants

Timeline

Start Date

October 1, 2022

Primary Completion Date

July 31, 2024

Study Completion Date

August 1, 2024

Conditions
Healthy Aging
Interventions
DEVICE

Continuous theta burst transcranial magnetic stimulation

Participants will receive cTBS (50Hz stimulation at 80% AMT for 40 seconds). Stimulation will be applied to either the target area (frontal pole or IFG) or control area (vertex). Targeting of each region will be achieved using a frameless neuronavigation system with a Polaris Spectra infrared camera that enables stimulation to be centered on specific coordinates in Montreal Neurological Institute space. We will use coordinates \[x,y,z\] = \[35,50,15\] for frontal pole and \[x,y,z\] = \[56,16,22\] for right IFG based on the location of our activations in the young pilot group (Figure 4). The vertex control site is defined as the Cz position of a 10-20 EEG system. After receiving TMS, participants will stare at a white wall for 1 minute before performing the Horizon Task for 45 minutes.

Trial Locations (1)

85721

University of Arizona, Tucson

All Listed Sponsors
collaborator

National Institute on Aging (NIA)

NIH

lead

University of Arizona

OTHER