iTBS-DCS in Obsessive Compulsive Disorder

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

81

Participants

Timeline

Start Date

November 26, 2021

Primary Completion Date

October 31, 2024

Study Completion Date

October 31, 2025

Conditions
Obsessive-Compulsive Disorder
Interventions
DEVICE

iTBS repetitive Transcranial Magnetic Stimulation (rTMS)

rTMS is a non-invasive procedure in which cerebral electrical activity is influenced by a rapidly changing magnetic field. The magnetic field is created by a plastic-encased coil which is placed over the patient's scalp. The magnetic field can be directed onto specific areas of the brain. rTMS can modulate cerebral activity by low or high frequencies. Over time, the magnetic field pulses can gradually change the activity level of the stimulated brain region and help symptoms of mood disorders.

DEVICE

Sham rTMS

Sham rTMS involves a click replicating the sound of the magnetic discharge, without any magnetic pulse being delivered.

DRUG

D-cycloserine

Daily oral D-cycloserine 100mg during TMS treatments (20 days).

DRUG

Placebo oral capsule

Daily oral placebo during the TMS treatments (20 days).

Trial Locations (1)

T2N 1N4

University of Calgary, Calgary

All Listed Sponsors
lead

University of Calgary

OTHER