81
Participants
Start Date
November 26, 2021
Primary Completion Date
October 31, 2024
Study Completion Date
October 31, 2025
iTBS repetitive Transcranial Magnetic Stimulation (rTMS)
rTMS is a non-invasive procedure in which cerebral electrical activity is influenced by a rapidly changing magnetic field. The magnetic field is created by a plastic-encased coil which is placed over the patient's scalp. The magnetic field can be directed onto specific areas of the brain. rTMS can modulate cerebral activity by low or high frequencies. Over time, the magnetic field pulses can gradually change the activity level of the stimulated brain region and help symptoms of mood disorders.
Sham rTMS
Sham rTMS involves a click replicating the sound of the magnetic discharge, without any magnetic pulse being delivered.
D-cycloserine
Daily oral D-cycloserine 100mg during TMS treatments (20 days).
Placebo oral capsule
Daily oral placebo during the TMS treatments (20 days).
University of Calgary, Calgary
University of Calgary
OTHER