Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Mismatch Repair Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma (MK-3475-C93/KEYNOTE-C93/GOG-3064/ENGOT-en15)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

280

Participants

Timeline

Start Date

February 3, 2022

Primary Completion Date

May 27, 2027

Study Completion Date

May 27, 2027

Conditions
Endometrial Neoplasms
Interventions
BIOLOGICAL

pembrolizumab

Intravenous (IV) infusion

DRUG

carboplatin

IV infusion

DRUG

paclitaxel

IV infusion

DRUG

docetaxel

IV infusion

DRUG

cisplatin

IV infusion

Trial Locations (195)

407

Taichung Veterans General Hospital ( Site 2602), Taichung

704

NATIONAL CHENG-KUNG UNI. HOSP. ( Site 2604), Tainan City

1000

Institut Jules Bordet-Medicine Oncology ( Site 0321), Brussels

1023

Auckland City Hospital-Cancer & Blood Research ( Site 1801), Auckland

1122

Országos Onkológiai Intézet-Ngyógyászat ( Site 1201), Budapest

2065

Northern Cancer Institute ( Site 0206), St Leonards

2100

Rigshospitalet ( Site 0903), Copenhagen

2145

Westmead Hospital-Department of Gynaecological Oncology ( Site 0201), Westmead

2730

Herlev and Gentofte Hospital ( Site 0902), Copenhagen

3000

Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 0207), Melbourne

3002

Epworth Freemasons ( Site 0203), Melbourne

3168

Monash Health ( Site 0202), Clayton

4000

Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman ( Site 0320), Liège

4029

Royal Brisbane and Women's Hospital-Medical Oncology Clinical Trials Unit, Cancer Care Services ( Si, Brisbane

6000

Grand Hôpital de Charleroi-Oncology & Hematology ( Site 0323), Charleroi

6008

St. John of God Subiaco Hospital-Oncology Clinical Trials Unit ( Site 0204), Subiaco

9000

Aalborg Universitetshospital, Syd ( Site 0905), Aalborg

10002

National Taiwan University Hospital ( Site 2603), Taipei

10011

The Blavatnik Family- Chelsea Medical Center at Mount Sinai ( Site 0023), New York

10016

Laura and Isaac Perlmutter Cancer Center at NYU Langone ( Site 0016), New York

10029

Icahn School of Medicine at Mount Sinai ( Site 0052), New York

10034

Fakultni nemocnice Kralovske Vinohrady-Gynekologicko-porodnická klinika ( Site 0408), Prague

10065

Memorial Sloan Kettering Cancer Center ( Site 0009), New York

10128

Ospedale Mauriziano-SCDU ONCOLOGIA MEDICA ( Site 1514), Turin

10449

Mackay Memorial Hospital ( Site 2601), Taipei

11217

Taipei Veterans General Hospital ( Site 2605), Taipei

12808

Vseobecna fakultni nemocnice v Praze-Gynekologicko-porodnicka klinika 1.LF a VFN ( Site 0405), Prague

13353

Charité Campus Virchow-Klinikum ( Site 1103), Berlin

15006

CHUAC-Complejo Hospitalario Universitario A Coruña ( Site 2405), A Coruña

15213

University of Pittsburgh Medical Center Magee-Womens Hospital ( Site 0034), Pittsburgh

15224

AHN West Penn Hospital ( Site 0011), Pittsburgh

19090

Asplundh Cancer Pavilion ( Site 0014), Willow Grove

19107

Sidney Kimmel Cancer Center - Jefferson Health ( Site 0053), Philadelphia

20133

Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Chirurgia Ginecologica ( Site 150, Milan

20141

Istituto Europeo di Oncologia IRCCS-Divisione di Ginecologia Oncologica ( Site 1506), Milan

20850

Maryland Oncology Hematology, P.A.-USOR Maryland Oncology Hematology, P.A. ( Site 8002), Rockville

22185

Skånes Universitetssjukhus Lund-Department of Hematology ( Site 2504), Lund

23219

VCU Health Adult Outpatient Pavillion ( Site 0022), Richmond

28034

Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 2402), Madrid

28374

FirstHealth Clinical Trials ( Site 0050), Pinehurst

30265

Southeastern Regional Medical Center ( Site 0046), Newnan

30342

Northside Hospital ( Site 0017), Atlanta

31009

COMPLEJO HOSPITALARIO DE NAVARRA ( Site 2407), Pamplona

33140

Mount Sinai Cancer Center ( Site 0018), Miami Beach

33520

Tampereen yliopistollinen sairaala-Gynecology and Obstetrics ( Site 1001), Tampere

34093

Istanbul University Capa Campus-department of obstetrics and gynaecology ( Site 2705), Istanbul

34098

Istanbul Universitesi Cerrahpasa ( Site 2702), Fatih

34239

Sarasota Memorial Hospital ( Site 0005), Sarasota

34440

T.C. Saglik Bakanligi Turkiye Kamu Hastaneleri Kurumu - Bakirkoy Dr. Sadi Konuk Egitim ve Arastirma, Istanbul

36100

AULSS8 Berica-Ospedale S.Bortolo-ONCOLOGIA CLINICA ( Site 1510), Vicenza

39216

St. Dominic's Hospital ( Site 0024), Jackson

40138

IRCCS - AOU di Bologna-SSD Oncologia medica Addarii ( Site 1503), Bologna

40503

Baptist Health Lexington ( Site 0042), Lexington

41013

HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO ( Site 2401), Seville

43210

The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C, Columbus

45219

University of Cincinnati Medical Center-University of Cincinnati Cancer Center ( Site 0039), Cincinnati

46009

Fundación Instituto Valenciano de Oncología-Oncologico ( Site 2404), Valencia

46260

St. Vincent Hospital and Health Care Center, Inc ( Site 0006), Indianapolis

47014

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori-Oncologia Medica ( Site 1513), Meldola

48201

Karmanos Cancer Institute ( Site 0029), Detroit

50134

Azienda Ospedaliera Universitaria Careggi-SOD ONCOLOGIA MEDICA ( Site 1509), Florence

53127

Universitätsklinikum Bonn-Gynaecological oncology ( Site 1105), Bonn

57104

Sanford Cancer Center-Gynecologic Oncology ( Site 0002), Sioux Falls

58122

Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 0055), Fargo

58501

Sanford Medical Center ( Site 0054), Bismarck

60099

Midwestern Regional Medical Center,Inc. DBA CTCA, Chicago ( Site 0003), Zion

62500

Fakultní nemocnice Brno Bohunice-Gynekologicko-porodnicka klinika ( Site 0404), Brno

70210

Kuopion Yliopistollinen Sairaala ( Site 1002), Kuopio

75246

Texas Oncology - Dallas-USOR Texas Oncology - Dallas (Sammons) ( Site 8005), Dallas

75702

Texas Oncology - Tyler-USOR Texas Oncology - Northeast Texas ( Site 8004), Tyler

78731

Texas Oncology - Austin-USOR Texas Oncology - Austin ( Site 8003), Austin

80131

Istituto Nazionale Tumori IRCCS Fondazione Pascale-S.C. Oncologia Sperimentale Uro-Genitale ( Site 1, Napoli

85016

HonorHealth-USOR HonorHealth ( Site 8000), Phoenix

89081

Universitaetsklinikum Ulm ( Site 1106), Ulm

92505

Kaiser Permanente Riverside Medical Center ( Site 0045), Riverside

97213

Providence Portland Medical Center ( Site 0031), Portland

100026

Beijing Obstetric and Gynecology Hospital ( Site 0740), Beijing

100034

Peking University First Hospital ( Site 0723), Beijing

100142

Beijing Cancer hospital ( Site 0715), Beijing

130021

The First Hospital of Jilin University ( Site 0705), Changchun

143423

Moscow City Oncology Hospital #62 ( Site 2204), Krasnogorsk

150054

Yaroslavl Regional Cancer Hospital-Oncology ( Site 2202), Yaroslavl

150081

Harbin Medical University Cancer Hospital ( Site 0711), Harbin

200011

Obstetrics & Gynecology Hospital of Fudan University ( Site 0702), Shanghai

201204

Shanghai First Maternity and Infant Hospital-Gynecology department ( Site 0717), Shanghai

210003

Jiangsu Province Hospital-Oncology Department ( Site 0707), Nanjing

230001

Anhui Provincial Hospital-Obstetrics and Gynecology ( Site 0730), Hefei

256603

Binzhou Medical University Hospital-Oncology department ( Site 0735), Binzhou

300060

Tianjin Medical University Cancer Institute and Hospital ( Site 0706), Tianjin

310006

The Affiliated Women's Hospital of Zhejiang University-Obstetrics and Gynecology ( Site 0726), Hangzhou

310022

Zhejiang Cancer Hospital-Oncology ( Site 0700), Hangzhou

325000

The First Affiliated Hospital of Wenzhou Medical University-Gynecology ( Site 0725), Wenzhou

330006

The First Affiliated Hospital of Nanchang University ( Site 0729), Nanchang

350014

Fujian Provincial Cancer Hospital ( Site 0720), Fuzhou

400038

Southwest Hospital of Third Military Medical University ( Site 0719), Chongqing

400072

2nd Affiliated Hospital Chongqing Medical Universi ( Site 0745), Chongqing

408000

Fuling Central Hospital ( Site 0733), Fulingqu

410008

Xiangya Hospital Central South University-Gynecology ( Site 0708), Changsha

410013

Hunan Cancer Hospital ( Site 0709), Changsha

430022

Wuhan Union Hospital-Medical Oncology ( Site 0716), Wuhan

450008

Henan Cancer Hospital ( Site 0713), Zhengzhou

510060

SUN YAT-SEN UNIVERSITY CANCER CENTRE ( Site 0710), Guangzhou

515041

Cancer Hospital of Shantou University Medical College ( Site 0732), Shantou

524004

Affiliated Hospital of Guangdong Medical College ( Site 0731), Zhanjiang

530021

Guangxi Medical University Affiliated Tumor Hospital-Gynecological oncology ( Site 0704), Nanning

570311

Hainan General Hospital ( Site 0703), Haikou

610066

West China Second University Hospital Sichuan University ( Site 0701), Chengdu

650118

Yunnan Province Cancer Hospital-Gynecology Department ( Site 0721), Kunming

710061

Shaanxi Provincial Cancer Hospital ( Site 0714), Xi'an

3109601

Rambam Health Care Campus-Gyneco-oncology unit ( Site 1402), Haifa

5265601

Sheba Medical Center ( Site 1401), Ramat Gan

5822012

Edith Wolfson Medical Center-Obstetrics & Gynecology ( Site 1405), Holon

7500921

FALP-UIDO ( Site 0602), Santiago

8330032

Pontificia Universidad Catolica de Chile-Centro del Cáncer ( Site 0604), Santiago

8410101

Soroka Medical Center ( Site 1403), Beersheba

8420383

Bradfordhill-Clinical Area ( Site 0603), Santiago

9103102

Shaare Zedek Medical Center ( Site 1404), Jerusalem

92093-0698

Moores Cancer Center ( Site 0037), La Jolla

06511

Yale-New Haven Hospital-Smilow Cancer Hospital at Yale-New Haven ( Site 0013), New Haven

01605

University of Massachusetts Medical School-Division of Gynecologic Oncology ( Site 0008), Worcester

07601

John Theurer Cancer Center at Hackensack University Medical Center ( Site 0026), Hackensack

59075-740

Liga Norte Riograndense Contra o Câncer-Centro de Pesquisa Clínica ( Site 3005), Natal

01246-000

ICESP - INSTITUTO DO CÂNCER DO ESTADO DE SÃO PAULO ( Site 3001), São Paulo

01509-010

A. C. Camargo Cancer Center-CAPEC ( Site 3003), São Paulo

T6G 1Z2

Cross Cancer Institute ( Site 0513), Edmonton

V1Y 5L3

BC Cancer Kelowna ( Site 0517), Kelowna

V5Z 4E6

BC Cancer Vancouver-Clinical Trials Unit ( Site 0518), Vancouver

M4N 3M5

Sunnybrook Health Sciences - Odette Cancer Centre ( Site 0509), Toronto

M5G 2M9

Princess Margaret Cancer Centre ( Site 0510), Toronto

H2X 3E4

Centre Hospitalier de l'Université de Montréal ( Site 0519), Montreal

H3T 1E2

Jewish General Hospital ( Site 0504), Montreal

H4A 3J1

McGill University Health Centre ( Site 0505), Montreal

S7N4H4

Saskatoon Cancer Center-Clinical Research Department ( Site 0520), Saskatoon

708 52

Fakultni nemocnice Ostrava-Gynekologicko-porodnicka klinika ( Site 0403), Ostrava

741 01

Nemocnice AGEL Novy Jicin a.s.-Oddeleni radioterapie a onkologie ( Site 0406), Nový Jiín

779 00

Fakultni nemocnice Olomouc-Onkologicka klinika ( Site 0402), Olomouc

180 00

Fakultni nemocnice Bulovka-Gynekologicko-porodnicka klinika ( Site 0401), Prague

762 75

Nemocnice Tomase Bati ve Zline-Onkologické oddělení ( Site 0407), Zlín

DK-4000

Roskilde Sygehus-Oncology department ( Site 0904), Roskilde

00290

Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus) ( Site 1003), Helsinki

01307

Universitaetsklinikum Carl Gustav Carus Dresden-Klinik und Poliklinik für Frauenheilkunde und Gebur, Dresden

T12 DV56

Bon Secours Cork Hospital ( Site 1305), Cork

D08 E9P6

St. James's Hospital-Cancer clinical trials office ( Site 1301), Dublin

oo168

Fondazione Policlinico Universitario Agostino Gemelli-Ginecologia Oncologica ( Site 1502), Rome

00144

Istituto Nazionale Tumori Regina Elena-Oncologia Medica 1 ( Site 1504), Rome

277-8577

National Cancer Center Hospital East ( Site 1604), Kashiwa

791-0280

National Hospital Organization Shikoku Cancer Center ( Site 1611), Matsuyama

791-0295

Ehime University Hospital ( Site 1614), Tōon

830-0011

Kurume University Hospital ( Site 1612), Kurume

373-8550

Gunma Prefectural Cancer Center-Gynecology ( Site 1603), Ōta

060-8648

Hokkaido University Hospital ( Site 1601), Sapporo

305-8576

Tsukuba University Hospital ( Site 1618), Tsukuba

028-3695

Iwate Medical University Hospital ( Site 1602), Shiwa-gun Yahaba-cho

951-8520

Niigata University Medical & Dental Hospital ( Site 1613), Chuo-ku, Niigata

350-1200

Saitama Medical University International Medical Center ( Site 1605), Hidaka-shi

411-8777

Shizuoka Cancer Center ( Site 1609), Nagaizumi-cho,Sunto-gun

104-0045

National Cancer Center Hospital ( Site 1607), Chuo-ku

135-8550

Japanese Foundation for Cancer Research ( Site 1616), Koto

105-8471

The Jikei University Hospital ( Site 1615), Minato-ku

160-8582

Keio university hospital ( Site 1606), Shinjyuku-ku

811-1395

National Hospital Organization Kyushu Cancer Center ( Site 1608), Fukuoka

541-8567

Osaka International Cancer Institute ( Site 1617), Osaka

6525 GA

Radboudumc-Medical Oncology ( Site 1703), Nijmegen

6229 HX

Maastricht UMC+ ( Site 1709), Maastricht

5623 EJ

Catharina Ziekenhuis-Oncology ( Site 1704), Eindhoven

1105 AZ

Amsterdam UMC, locatie AMC ( Site 1706), Amsterdam

2333 ZA

Leids Universitair Medisch Centrum-Medical Oncology ( Site 1702), Leiden

3015 GD

Erasmus Medisch Centrum-Medical Oncology ( Site 1701), Rotterdam

9713 GZ

University Medical Center Groningen ( Site 1707), Groningen

3584 CX

Universitair Medisch Centrum Utrecht-Medical Oncology ( Site 1705), Utrecht

0379

Oslo universitetssykehus, Radiumhospitalet ( Site 1901), Oslo

61-848

Szpital Kliniczny im. Heliodora Święcickiego Uniwersytetu Me-Oddzial Ginekologii Onkologicznej ( Sit, Poznan

20-090

Centrum Onkologii Ziemi Lubelskiej ( Site 2006), Lublin

08-110

Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 2007), Siedlce

00-315

Szpital Kliniczny im. Księżnej Anny Mazowieckiej ( Site 2009), Warsaw

02-781

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Ginekologii Onkologicznej ( Sit, Warsaw

15-027

Bialostockie Centrum Onkologii-Oddzial Onkologii Ginekologicznej ( Site 2003), Bialystok

44-102

Narodowy Instytut Onkologii - Oddzial w Gliwicach-III Klinika Radioterapii i Chemioterapii ( Site 20, Gliwice

25-734

Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zaklad Opieki Zdrowotnej ( Site 2010), Kielce

03080

Seoul National University Hospital ( Site 2302), Seoul

03722

Severance Hospital, Yonsei University Health System-Gynecologic cancer center ( Site 2301), Seoul

05505

Asan Medical Center-Division of Gynecologic Oncology, Dept. of Obstetrics & Gynecology ( Site 2303), Seoul

06273

Gangnam Severance Hospital ( Site 2304), Seoul

08907

Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 2406), Hospitalet

08035

Hospital Universitari Vall d'Hebron ( Site 2403), Barcelona

171 64

Karolinska Universitetssjukhuset Solna ( Site 2502), Solna

901 85

Norrlands universitetssjukhus-Cancercentrum ( Site 2503), Umeå

06230

Hacettepe Universite Hastaneleri-oncology hospital ( Site 2704), Ankara

06800

Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 2706), Ankara

07070

Akdeniz Universitesi Hastanesi ( Site 2701), Antalya

EC1A 7BE

St Bartholomew's Hospital ( Site 2804), London

M20 4BX

The Christie ( Site 2807), Manchester

G12 0YN

The Beatson West of Scotland Cancer Centre ( Site 2805), Glasgow

SW3 6JJ

ROYAL MARSDEN HOSPITAL (CHELSEA) ( Site 2806), London

W12 OHS

Hammersmith Hospital-Medical Oncology ( Site 2808), London

All Listed Sponsors
collaborator

European Network of Gynaecological Oncological Trial Groups (ENGOT)

OTHER

collaborator

GOG Foundation

NETWORK

lead

Merck Sharp & Dohme LLC

INDUSTRY