Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC

PHASE4RecruitingINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

October 1, 2021

Primary Completion Date

November 1, 2025

Study Completion Date

November 1, 2026

Conditions
Systemic Inflammatory Response SyndromePostoperative Pain, AcutePostoperative Pain, ChronicInfections PostoperativeOpioid UseAnesthesiaNon-small Cell Lung Cancer
Interventions
DRUG

Opioid-Based Anesthesia-Analgesia Strategy

"A perioperative Opioid-Based multimodal Anesthesia- Analgesia strategy will be implemented that incorporates the following pharmacological agents:~Premedication: Midazolam, Anaesthesia induction \& maintenance: Midazolam, Propofol, Fentanyl, Cisatracurium or alternatively Rocuronium, Desflurane, Morphine, Paracetamol, Dexketoprofen trometamol, Ondansetron or Droperidol, Ropivacaine Surgical ward: Morphine, Paracetamol, Dexketoprofen trometamol Rescue therapy only: Tramadol"

DRUG

Opioid-free Anesthesia-Analgesia Strategy

"A perioperative Opioid-Based multimodal Anesthesia- Analgesia strategy will be implemented that incorporates the following pharmacological agents:~Premedication: Pregabalin, Midazolam, Anesthesia induction \& maintenance: Midazolam, Dexmedetomidine, Lidocaine, Propofol, Ketamine, Hyoscine, Cisatracurium or alternatively Rocuronium, Magnesium sulphate, Dexamethasone, Desflurane, Paracetamol, Dexketoprofen trometamol, Ondansetron or Droperidol, Ropivacaine, Surgical ward: Ketamine, Lidocaine, Clonidine, Droperidol and Midazolam, Pregabalin, Paracetamol, Dexketoprofen trometamol Rescue therapy only: Tramadol"

Trial Locations (1)

71110

RECRUITING

University of Crete, Heraklion

All Listed Sponsors
lead

University of Crete

OTHER

NCT05172739 - Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC | Biotech Hunter | Biotech Hunter