NCT05160493View on ClinicalTrials.gov

The Effect of Esketamine Combined With Pregabalin on Chronic Postsurgical Pain in Patients After Craniotomy.

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

246

Participants

Timeline

Start Date

December 20, 2021

Primary Completion Date

December 11, 2023

Study Completion Date

June 20, 2024

Conditions
Chronic Postsurgical Pain
Interventions
DRUG

S-ketamine and pregabalin

"S-ketamine and pregabalin~* Drug: Pregabalin • 150mg (2hrs) pre operatively and 75mg twice daily post operatively for 7 days(POD1-7),followed by dose reduction to 75mg once daily for 7days(POD8-14)~* Drug: S-ketamine infusion • 0.5 mg/kg bolus after induction of anesthesia +0.12 mg/kg/h continuous intravenous infusion for 48 h"

DRUG

Normal saline and placebo capsule

Normal saline and placebo capsule

Trial Locations (1)

100070

Beijing Tiantan Hospital, Capital Medical University, Beijing

All Listed Sponsors
lead

Beijing Tiantan Hospital

OTHER

NCT05160493 - The Effect of Esketamine Combined With Pregabalin on Chronic Postsurgical Pain in Patients After Craniotomy. | Biotech Hunter | Biotech Hunter