Safety, Tolerability, and Immunogenicity of V110 or V114 Co-administered With a Booster Dose of mRNA-1273 in Healthy Adults (V110-911)

PHASE3CompletedINTERVENTIONAL
Enrollment

850

Participants

Timeline

Start Date

January 12, 2022

Primary Completion Date

February 21, 2023

Study Completion Date

February 21, 2023

Conditions
Pneumococcal Infection
Interventions
BIOLOGICAL

V110

Single intramuscular (IM) dose of 0.5 mL V110, a pneumococcal polysaccharide vaccine (PCV), containing the 23 serotypes: 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, and 33F

BIOLOGICAL

V114

Single IM dose of 0.5 mL V114 a 15-valent PCV containing the 15 serotypes: 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 22F, 23F, 33F

BIOLOGICAL

mRNA-1273

Single IM dose of 50 μg/0.25 mL mRNA-1273

BIOLOGICAL

Placebo for V110

Single IM dose of 0.5 mL placebo for V110

BIOLOGICAL

Placebo for V114

Single IM dose of 0.5 mL placebo for V114

Trial Locations (46)

13045

Certified Research Associates ( Site 0042), Cortland

14609

Rochester Clinical Research, Inc. ( Site 0010), Rochester

14845

Corning Center for Clinical Research ( Site 0052), Horseheads

21075

Centennial Medical Group ( Site 0016), Elkridge

22911

Charlottesville Medical Research Center, LLC ( Site 0008), Charlottesville

23226

Clinical Research Partners, LLC. ( Site 0005), Richmond

23502

Alliance for Multispecialty Research LLC (AMR - Norfolk) ( Site 0057), Norfolk

23606

Health Research of Hampton Roads, Inc. ( Site 0014), Newport News

27103

Accellacare - Winston-Salem ( Site 0049), Winston-Salem

29405

Coastal Carolina Research Center ( Site 0044), North Charleston

30331

Atlanta Center For Medical Research ( Site 0053), Atlanta

32934

Optimal Research LLC ( Site 0019), Melbourne

33012

Indago Research and Health Center Inc ( Site 0006), Hialeah

33014

Lakes Research LLC ( Site 0012), Miami Lakes

33134

Alliance for Multispecialty Research, LLC ( Site 0036), Coral Gables

33174

Advanced Medical Research, LLC ( Site 0030), Miami

40509

AMR Lexington ( Site 0055), Lexington

44122

Velocity Clinical Research- Cleveland ( Site 0023), Cleveland

61614

Optimal Research ( Site 0054), Peoria

64114

Alliance for Multispecialty Research, LLC ( Site 0011), Kansas City

67114

Alliance for Multispecialty Research, LLC ( Site 0018), Newton

75071

Wellness Clinical Research Associates ( Site 0051), McKinney

76135

Benchmark Research ( Site 0039), Fort Worth

77081

Texas Center For Drug Development ( Site 0013), Houston

77375

DM Clinical Research ( Site 0025), Tomball

77901

Crossroads Clinical Research LLC ( Site 0020), Victoria

78229

Diagnostics Research Group ( Site 0001), San Antonio

78413

South Texas Clinical Research ( Site 0033), Corpus Christi

78705

Benchmark Research ( Site 0007), Austin

84088

Velocity Clinical Research, Salt Lake City ( Site 0035), West Jordan

87505

AXCES Research Group ( Site 0017), Santa Fe

89106

Wake Research Clinical Research Center of Nevada, LLC ( Site 0021), Las Vegas

90723

Center for Clinical Trials, LLC ( Site 0022), Paramount

91325

Valley Clinical Trials Inc. ( Site 0002), Northridge

91606

Carbon Health ( Site 0045), North Hollywood

92103

Artemis Institute for Clinical Research ( Site 0024), San Diego

92123

California Research Foundation ( Site 0004), San Diego

93065

Millennium Clinical Trials ( Site 0027), Simi Valley

94598

Diablo Clinical Research, Inc ( Site 0043), Walnut Creek

01752

Community Clinical Research Center ( Site 0032), Marlborough

02818

Velocity Clinical Research-Providence ( Site 0015), East Greenwich

77555-1115

University of Texas Medical Branch at Galveston ( Site 0037), Galveston

00961

Cooperativa de Facultad Medica SANACOOP ( Site 0104), Bayamón

00716

CAIMED Center - Ponce School of Medicine ( Site 0103), Ponce

00745

Caparra Internal Medicine Research Center. PSC ( Site 0102), Río Grande

00909

Clinical Research Puerto Rico ( Site 0105), San Juan

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY