705
Participants
Start Date
July 22, 2022
Primary Completion Date
April 30, 2026
Study Completion Date
April 30, 2026
Irinotecan
Irinotecan 75 mg/m² intravenously Days 1 \& 8 q3wk
Lurbinectedin
Lurbinectedin 3.2 mg/m² will be administered intravenously on Day 1 q3wk
Irinotecan
For patients aged \<70 years: irinotecan 350 mg/m² intravenously Day 1 q3wk For patients aged ≥70 years: irinotecan 300 mg/m² intravenously Day 1 q3wk
Topotecan
Topotecan 2.3 mg/m² oral or 1.5 mg/m² intravenously Days 1-5 q3wk
Lurbinectedin
Lurbinectedin 2.0 mg/m² will be administered intravenously on Day 1 q3wk
National Taiwan University Cancer Center, Taipei
Todua Clinic, Tbilisi
New Hospitals, Tbilisi
Institute Of Clinical Oncology, Tbilisi
"JSC Evex Hospitals Caraps Medline", Tbilisi
LTD Cancer Research Centre, Tbilisi
Changhua Christian Hospital, Chang-hua
Centre Hospitalier Universitaire Vaudois, Lausanne
Specialized hospital for active treatment of oncological diseases, Sofia
Multiprofile Hospital for Active Treatment Serdika EOOD Second Department of Medical Oncology, Sofia
HFR Freiburg Kantonsspital, Villars-sur-Glâne
Pulmonology Hospital Torokbalint, Törökbálint
The Chris Obrien Lifehouse, Camperdown
Gosford Hospital GH - Central Coast Cancer Centre, Gosford
Antwerp University Hospital, Edegem
Az Sint Maarten Mechelen, Mechelen
Algemeen Ziekenhuis AZ Klina - Borstkliniek, Brasschaat
Box Hill Hospital Eastern Health Clinical School, Box Hill
BRICC - Ballarat Health Services, Ballarat Central
Centre Hospitalier Chretien CHC - MontLegia, Liège
CHR de la Citadelle, Liège
CHU Liege, Liège
Complex Oncology Center - Plovdiv EOOD, First Department of Medical Oncology and Oncological Diseases in Gastroenterology, Plovdiv
University Hospital Basel, Basel
Debreceni Egyetem - Klinikai Kozpont, Debrecen
Kantonsspital Baselland, Liestal
Multiprofile Hospital for Active Treatment - Uni Hospital OOD Department of Medical Oncology, Panagyurishte
Sjællands Universitetshospital, Næstved
Hetenyi G Korhaz, Onkologiai Kozpont, Szolnok
Grand Hopital de Charleroi GHdC - Hopital Saint Joseph, Charleroi
High Technology Hospital Medcenter, Batumi
Bacs-Kiskun County Hospital, Kecskemét
Sønderborg Sygehus, Sønderborg
Istituto Oncologico della Svizzera Italiana, Bellinzona
Centre Hospitalier Universitaire (CHU) Ambroise Pare, Mons
Vejle Hospital, Vejle
Spital Thurgau - Kantonspital Frauenfeld, Frauenfeld
Veszprem Megyei Tudogyogyintezet Farkasgyepu, Farkasgyepű
Spital Thurgau - Kantonsspital Muensterlingen, Münsterlingen
Aalborg University Hospital, Aalborg
Azienda Ospedaliero-Universitaria San Luigi Gonzaga, Orbassano
A.O. Santa Croce e Carle, Ospedale Carle, Cuneo
Evangelische Lungenklinik Berlin, Berlin
CHA Bundang Medical Center, CHA University, Gyeonggi-do
Centre François Baclesse, Caen
Hospital Universitario Reina Sofía, Córdoba
CHU de Caen - Hopital Cote de Nacre, Caen
Hospital Teresa Herrera C.H.U.A., A Coruña
A.O. SS. Antonio e Biagio e Cesare Arrigo di Alessandria, Alessandria
ASL 3 Genovese Oncologia Medica Villa Scassi, Genova
The Catholic University of Korea, St.Vincents Hospital, Gyeonggi-do
IRCCS Istituto Clinico Humanitas - Cancer Center, Milan
ASST Sette Laghi, Varese
Gachon University Gil Medical Center, Incheon
Inha University Hospital, Incheon
LungenClinic Grosshansdorf, Großhansdorf
ASST Valtellina e Alto Lario Ospedale di Sondrio, Sondrio
Hopital Jean Minjoz, Besançon
Hospital Universitario Lucus Augusti, Lugo
Hospital Universitario La Paz, Madrid
Hospital General Universitario Gregorio Marañón, Madrid
Clínica Universidad de Navarra, Madrid
MD Anderson Cancer Center, Madrid
Hospital Universitario Ramón y Cajal, Madrid
Hospital Clínico San Carlos, Madrid
Hospital Universitario Fundación Jimenez Díaz, Madrid
Hospital Universitario 12 de Octubre, Madrid
Hospital Universitario HM Sanchinarro, Madrid
Ospedale Maggiore di Novara, Novara
Klinikum Bremen Ost, Bremen
FirstHealth Outpatient Cancer Center, Pinehurst
Chungbuk National University Hospital, Cheongju-si
Hospital Regional Universitario Málaga Hospital Civil, Málaga
Azienda USL di Piacenza, Piacenza
Hopital Morvan CHU de Brest, Brest
Clínica Universidad de Navarra, Pamplona
Florida Cancer Specialists - Panhandle, Tallahassee
IRCCS Centro di Riferimento Oncologico, Aviano
Florida Cancer Specialists - East, West Palm Beach
Florida Cancer Specialists - North, St. Petersburg
Florida Cancer Specialists - South, Fort Myers
Klinikum Kassel - Medizinische Klinik IV, Kassel
Bagcilar Medipol Mega University Hospital, Bağcılar
Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Kadıköy
Complejo Hospitalario Materno-Insular de Gran Canaria, Las Palmas de Gran Canaria
Oncologia Medica II Istituto Oncologico Veneto IRCCS, Padua
Complexo Hospitalario Universitario De Vigo (CHUVI) - Hospital Xeral, Vigo
Hospital Universitario Marqués de Valdecilla, Santander
IRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico S. Orsola Malpighi Oncologia medica, Bologna
Norton Cancer Institue, Downtown, Louisville
Hospital Universitario Virgen del Rocío, Seville
Kocaeli University Hospital, İzmit
Hospital Universitari i Politècnic La Fe, Valencia
Hospital Clínico Universitario de Valladolid, Valladolid
Rabin Medical Center, Petah Tikva
Hospital Clínico Universitario Lozano Bleza, Zaragoza
AOU Careggi, Florence
CHU Reims - Hpital Maison Blanche, Reims
Froedtert Hospital/Medical College of Wisconsin, Milwaukee
Azienda Ospedaliero Universitaria delle Marche, Ancona
Duly Health and Care, Joliet
Sana Klinikum Offenbach, Offenbach
Hopital Civil / Nouvel Hopital Civil, Strasbourg
Oncology Hematology West, PC dba Nebraska Cancer Specialists, Omaha
Universitaetsmedizin Mannheim, Mannheim
Oncology Hematology West, PC (Grand Island), Grand Island
Thoraxclinic Heidelberg GmbH, Heidelberg
Genesis Cancer and Blood, Hot Springs
Klinikum Esslingen GmbH, Esslingen am Neckar
Helios St. Johannes Klinikum, Duisburg
Klinik Loewenstein gGmbH, Löwenstein
Bichat-Claude Bernard Hospital, Paris
Vincentius-Diakonissen-Kliniken gAG Karlsruhe, Karlsruhe
Universittsklinikum Freiburg, Freiburg im Breisgau
Universita degli Studi della Campania Luigi Vanvitelli, Napoli
Staedtisches Klinikum München - Bogenhausen, München
Asklepios Fachklinik München-Gauting, Gauting
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City
Utah Cancer Specialists, Salt Lake City
Irccs-Crob, Rionero in Vulture
Ironwood Cancer & Research Centers, Chandler
Centre Hospitalier Universitaire CHU De Limoges, Limoges
AssAP-HP - Hopital Ambroise-Pare, Boulogne-Billancourt
Hospital Foch, Suresnes
Centre Hospitalier Intercommunal de Creteil (CHIC), Créteil
Gustave Roussy, Villejuif
Azienda Ospedaliera Univ. Policlinico G Rodolico San Marco, Catania
MultiCare Regional Cancer Center - Tacoma, Tacoma
Zentralklinik Bad Berka GmbH, Bad Berka
Oncolab SRL, Craiova
Centrul de Oncologie Sfantu Nectarie, Craiova
Oncocenter Oncologie clinica S.R.L, Timișoara
Medisprof srl, Cluj-Napoca
Buddhist Dalin Tzu Chi Hospital, Dalin
Rambam Health Care Campu, Haifa
James Lind Centro de Investigación del Cáncer, Temuco
Clinical Research Chile SpA, Valdivia
Tel Aviv Sourasky Medical Center, Tel Aviv
Ovidius Clinical Hospital, Ovidiu
Shaare Zedek Medical Center, Jerusalem
Dana-Farber Cancer Institute, Boston
Northern Beaches Hospital, Frenchs Forest
Austin Hospital- Medical Oncology Unit, Heidelberg
St John of God Murdoch Hospital, Murdoch
Cancer Care Wollongong, Wollongong
University Hospital Salzburg, Salzburg
Medizinische Universitaet Wien, Vienna
Oncocentro-Centro de Oncologia do Parana, Curitiba
Irmandade daSanta Casa de Misericordia de Porto Alegre, Porto Alegre
Hospital Sao Lucas da PUCRS, Porto Alegre
UPCO - Hospital de Clinicas de Porto Alegre, Santa Cecília
Nucleo de Oncologia da Bahia - NOB, Ondina
Fundacao Pio XII - Hospital de Cancer de Barretos - Hospital de Amor, Barretos
ONCOSITE - Centro de Pesquisa Clinica em Oncologia Ltda, Ijuí
Instituto Nacional de Cancer - Ministrio da Sade, Rio de Janeiro
Hamilton Health Sciences -Juravinski Cancer Centre, Hamilton
Southlake Regional Health Centre, Newmarket
Hôpital de la Cité-de-la- Santé, Laval
CISSS de la Montérégie-Centre - Hôpital Charles LeMoyne, Longueuil
McGill University Health Centre (MUHC), Montreal
University Health Network - Princess Margaret Hospital, Toronto
Centro de Estudios Clínicos SAGA, Santiago
Clinica Alemana de Santiago, Santiago
Clínica Santa María, Santiago
Fundación Arturo López Pérez, Santiago
Hospital Clinico Universidad de Chile, Santiago
The Chaim Sheba Medical Center, Ramat Gan
Osaka Habikino Medical Center, Habikino
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Bunkyō-Ku
CHU de Nantes, Nantes
Krankenhaus Martha-Maria Halle gGmbH, Halle
Universitaetsklinikum Halle Saale, Halle
Fondazione Policlinico Universitario Campus Bio-Medico, Roma
IFO Regina Elena, Roma
Hirosaki University Hospital, Hirosaki
Kyushu University Hospital, Fukuoka
Kobe City Medical Center General Hospital, Kobe
Kanazawa University Hospital, Kanazawa
Sendai Kousei Hospital, Sendai
Ohara HealthCare Foundation Kurashiki Central Hospital, Kurashiki
Kansai Medical University Hospital, Hirakata-shi
Izumi City General Hospital, Izumi
Kanagawa Cancer Center, Izumi
Kishiwada City Hospital, Kishiwada
The Cancer Institute Hospital Of JFCR, Koto-Ku
Center Hospital of the National Center for Global Health and Medicine, Shinjuku-Ku
II Klinika Chorob Pluc i Gruzlicy, Bialystok
Szpitale Pomorskie Sp. z o.o., Oddzial Onkologii K, Gdynia
Wojewódzkie Wielospecjalistyczne Centrum Onkologii, Lodz
Specjalistyczna Praktyka Lekarska Slawomir Mandziuka, Lublin
Szpital Specjalistyczny w Prabutach Sp. z o.o, Prabuty
Mrukmed. Lekarz Beata Madej-Mruk i Partner. Sp.p, Rzeszów
Specjalistyczny Szpital Onkologiczny NU-MED sp. Z, Tomaszów Mazowiecki
Sc Oncopremium Team Srl, Baia Mare
Kangbuk Samsung Hospital, Seoul
Asan Medical Center, Seoul
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul
Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul
Institut Català d Oncologia (ICO) - Hospital Germans Trias i Pujol, Badalona
Hospital Universitari Vall d'Hebron, Barcelona
Institut Catala d'Oncologia (ICO) - Hospital Duran i Reynals, L'Hospitalet de Llobregat
Medicalpark Seyhan Hospital, Seyhan
Liv Hospital Ankara, Çankaya
Belfast Health and Social Care Trust, Belfast
The Princess Alexandra Hospital, Harlow
Guys and St Thomas NHS Foundation Trust, London
The Christie NHS Foundation Trust, Manchester
Clatterbridge Hospital, Metropolitan Borough of Wirral
Nottingham University Hospitals NHS Trust, Nottingham
The Royal Wolverhampton NHS Trust, Wolverhampton
Lead Sponsor
PharmaMar
INDUSTRY