920
Participants
Start Date
December 2, 2021
Primary Completion Date
December 1, 2025
Study Completion Date
May 15, 2026
Zanidatamab
Administered IV
Tislelizumab
Administered IV
Trastuzumab
Administered intravenously (IV)
Capecitabine
Administered orally (PO bid)
Oxaliplatin
Administered IV
Cisplatin
Administered IV
5-Fluorouracil
Administered IV
St James's Hospital, Dublin
Cliniques Universitaires Saint-Luc, Brussels
Hospital de Gastroenterología Dr Bonorino Udaondo, Buenos Aires
Liverpool Hospital, Liverpool
Centro de Investigación Pergamino S.A., Pergamino
Imelda VZW, Bonheiden
UZ Leuven, Leuven
Austin Health, Heidelberg
CHU de Liège, Liège
Flinders Medical Centre, Bedford Park
High Technology Hospital MedCenter Ltd, Tbilisi
Fiona Stanley Hospital, Murdoch
Hospital Universitario Germans Trias i Pujol, Badalona
UZ Gent, Ghent
Fondazione del Piemonte per l'Oncologia (IRCCS), Candiolo
National Cancer Center, Goyang-si
Hospital Pulau Pinang, George Town
University Clinical Center of Serbia - PPDS, Belgrade
Clinical Hospital Center Bezanijska Kosa, Belgrade
Taipei Veterans General Hospital, Taipei
North Estonia Medical Centre Foundation, Tallinn
CHA Bundang Medical Center, CHA University, Seongnam-si
Seoul National University Bundang Hospital, Seongnam-si
Hallym University Sacred Heart Hospital, Anyang-si
Ospedale Policlinico San Martino, Genova
Hospital Universitari de Girona Dr Josep Trueta, Girona
University Clinical Center Nis, Niš
Ospedale San Raffaele S.r.l. - PPDS, Milan
Istituto Nazionale Dei Tumori, Milan
ASST Grande Ospedale Metropolitano Niguarda - Presidio Ospedaliero Ospedale Niguarda, Milan
Universite de Bourgogne - Faculte de Medecine - IN, Dijon
Oncology Institute of Vojvodina, Kamenitz
Gachon University Gil Medical Center, Incheon
Trakya University Medical Faculty, Edirne
Hospital Universitario Ramon y Cajal, Madrid
Hospital Universitario La Paz - PPDS, Madrid
Hospital Regional Universitario de Malaga - Hospital General, Málaga
Complejo Hospitalario de Navarra, Pamplona
Complejo Asistencial Universitario de Salamanca - H. Clinico, Salamanca
EDOG - Institut Bergonie - PPDS, Bordeaux
CHU de Bordeaux - Hopital Haut Leveque, Pessac
EDOG - Centre Eugene Marquis Centre Regional de Lutte Contre Le Cancer - PPDS, Rennes
Dokuz Eylul Universitesi, Izmir
"Azienda ULSS 8 Berica - Ospedale San Bortolo", Vicenza
Centro Ricerche Cliniche Di Verona, Verona
Centre Hospitalier Universitaire Grenoble Alpes - Hopital Albert Michallon, Grenoble
Hospital Universitario Marques de Valdecilla, Santander
Srinagarind Hospital, Khon Kaen University, Khon Kaen
Azienda Ospedaliero Universitaria Di Bologna - Policlinico S Orsola Malpighi, Bologna
Hospital Universitario Virgen Macarena, Seville
Azienda Ospedaliero Universitaria Di Modena Policlinico, Modena
Kyungpook National University Chilgok Hospital, Daegu
CHRU de Brest - Hopital Morvan, Saint-Priest-en-Jarez
The Municipal Enterprise Volyn Regional Medical Oncology Centre of the Volyn Regional Council, Lutsk
Arcispedale Santa Maria Nuova, Reggio Emilia
EDOG Institut de Cancerologie de l'Ouest - PPDS, Nantes
Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori IRST - PPDS, Meldola
Dong-A University Hospital, Busan
Hospital Universitario Miguel Servet, Zaragoza
The Fourth Hospital of Hebei Medical University, Shijiazhuang
Bioclinic Thessaloniki Oncology Department, Thessaloniki
Interbalkan Medical Center of Thessaloniki Oncology Department, Thessaloniki
Institut für Klinisch-Onkologische Forschung, Frankfurt am Main
Medical Park Trabzon Yildizli, Trabzon
National Cancer Institute ( Institut Kanser Negara), Putrajaya
Hospital Universitario Dr. Jose Eleuterio González, Monterrey
Centro de Investigacion Clinica de Oaxaca, Oaxaca City
Centre Léon Berard, Lyon
Hôpital de Rangueil, Toulouse
Sainte-Catherine, Institut du Cancer Avignon Provence, Avignon
CHRU de Poitiers La Miletrie, Poitiers
Songklanagarind Hospital, Hat Yai
Sarawak General Hospital, Kuching
Hôpital Saint Antoine, Villejuif
Beijing Chao-Yang Hospital, Capital Medical University, Beijing
Cancer Hospital Chinese Academy of Medical Sciences, Beijing
Beijing Cancer Hospital, Beijing
Peking University Third Hospital, Beijing
Beijing Luhe Hospital, Capital Medical University, Beijing
Indraprastha Apollo Hospitals, New Delhi
Liaoning Cancer Hospital & Institute, Shenyang
Artemis Hospital, Gūrgaon
The Tonghua Central Hospital, Tonghua
Harbin Medical University Cancer Hospital, Harbin
Ruijin hospital Shanghai Jiao Tong University School of Medicine, Shanghai
Fudan University Affiliated Zhongshan Hospital, Shanghai
Fudan University Shanghai Cancer Center, Shanghai
Shanghai General Hospital, Shanghai
Oncology Center Sfantul Nectarie, Craiova
Nanjing Drum Tower Hospital ,The Affiliated Hospital of Nanjing University Medical School, Nanjing
Changzhou First People's Hospital, Changzhou
Affiliated Hospital of Jiangnan University, Wuxi
Northern Jiangsu People's Hospital, Yangzhou
Anhui Provincial Cancer Hospital, Hefei
The Second Affiliated Hospital of Anhui Medical University, Hefei
The First Affiliated Hospital of Bengbu Medical College, Bengbu
Shandong Cancer Hospital, Jinan
Jinan Central Hospital, Jinan
National Cancer Center Singapore, Singapore
Weihai Municipal Hospital, Weihai
The Affiliated Hospital of Qingdao University, Qingdao
Tianjin Medical University General Hospital, Tianjin
Tianjin Medical University Cancer Institute & Hospital, Tianjin
The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou
Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou
Zhejiang Cancer Hospital, Hangzhou
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou
The First Affiliated Hospital of Nanchang University, Nanchang
The First Affiliated Hospital of Fujian Medical University, Fuzhou
Fujian Cancer Hospital, Fuzhou
The First Affiliated Hospital of Xiamen University, Xiamen
Prof Dr I Chiricuta Institute of Oncology - PPDS, Cluj-Napoca
Medisprof SRL, Cluj-Napoca
China Medical University Hospital, Taichung
Hunan Cancer Hospital, Changsha
Union Hospital Tongji Medical College HuaZhong University of Science and Technology, Wuhan
Hubei Cancer Hospital, Wuhan
Henan Cancer Hospital, Zhengzhou
The First Affiliated Hospital of Zhengzhou University, Zhengzhou
MNJ Institute of Oncology and Regional Cancer Centre, Hyderabad
Guangdong Provincial People's Hospital, Guangzhou
The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou
HCG City Cancer Center, Vijayawada
Hainan General Hospital, Haikou
Sichuan Cancer Hospital & Institute, Chengdu
Yunnan Cancer Hospital, Kunming
First Affiliated Hospital of Xi 'an Jiaotong University, Xi'an
The First Hospital of Lanzhou University, Lanzhou
Gansu Cancer Hospital, Lanzhou
All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar
Regional Cancer Centre Indira Gandhi Institute of Medical Sciences, Patna
Cancer Hospital affiliated to Xinjiang Medical University, Ürümqi
Sociedad de Investigaciones Medicas Limitada, Temuco
Fundación Arturo López Pérez (FALP) - PPDS, Providencia
Centro de Estudios Clínicos SAGA SpA, Providencia
Sociedad Oncovida S.A, Santiago
Icegclinic, Santiago
BIOCINETIC SpA, Santiago
Centro Internacional de Estudios Clinicos CIEC, Santiago
Instituto de Investigaciones Metabólicas - IDIM, Buenos Aires
Hospital Italiano de Buenos Aires, Buenos Aires
Fundación Centro de Medicina Nuclear y Molecular ER, Córdoba
Centro Médico Privado CEMAIC, Córdoba
Centro de Investigación Clínica - Clínica Viedma, Viedma
Centro Integrado de Pesquisa - CIP, Barretos
Fundação Pio XII Hospital de Câncer de Barretos, Barretos
Cenantron - Centro Avancado de Tratamento Oncologico Ltda, Belo Horizonte
Centro de Pesquisas Clínicas/Fundação Doutor Amaral Carvalho, Brasília
Instituto Do Câncer Do Ceará ICC, Fortaleza
Hospital de Clinicas de Porto Alegre (HCPA) - PPDS, Porto Alegre
Irmandade Da Santa Casa de Misericordia de Porto Alegre, Porto Alegre
Hospital Nossa Senhora Da Conceição, Porto Alegre
Núcleo de Pesquisa Clínica da Rede São Camilo, Santo André
Instituto do Cancer do Estado de São Paulo ICESP, São Paulo
Instituto de Oncologia de Sorocaba, Sorocaba
Princess Margaret Cancer Centre, Toronto
Changzhi People's Hospital, Changzhi
Affiliated Hospital of Inner Mongolia Medical University, Hohhot
Research Institute of Clinical Medicine, Tbilisi
Attikon University General Hospital, Athens
Agios Loucas Clinic SA, Thessaloniki
Clinica Medica Especializada CELAN, Guatemala City
Grupo Medico Angeles, Guatemala City
Centro Medico Integral de Cancerologia CEMIC, Salcajá
Fondazione Policlinico Universitario A Gemelli, Rome
Chiba Cancer Center, Chiba
National Cancer Center Hospital East, Kashiwa-shi
Gifu University Hospital, Gifu
Gunma Prefectural Cancer Center, Ota-shi
Hyogo Cancer Center, Akashi-shi
Ibaraki Prefectural Central Hospital, Kasama-Shi
Kagawa University Hospital, Kita-Gun Miki-Cho
Kanagawa Cancer Center, Yokohama-Shi Asahi-Ku
Kumamoto University Hospital - Honjo-Kuhonji Campus A, Chuo-Ku
Kyoto University Hospital, Sakyo-ku
Osaki Citizen Hospital, Osaki-Shi
Kurashiki Central Hospital, Kurashiki-Shi
Osaka University Hospital, Suita-Shi
Osaka Medical and Pharmaceutical University Hospital, Takatsuki-Shi
Keio University Hospital, Shinjuku-Ku
National Cancer Center Hospital, Chūōku
National Hospital Organization Kyushu Cancer Center, Fukuoka
Saitama Cancer Center, Ina
Shikoku Cancer Center, Matsuyama
Osaka International Cancer Institute, Osaka
Kindai University Hospital, Ōsaka-sayama
The Cancer Institute Hospital of Japanese Foundation For Cancer Research, Tokyo
Health Pharma Professional Research S.A de C.V., Mexico City
Catharina Hospital, Eindhoven
Leids Universitair Medisch Centrum, Leiden
ETZ-Elisabeth, Tilburg
Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi, Lodz
Centrum Onkologii Instytut im. Marii Sklodowskiej-Curie, Warsaw
Hospital Garcia de Orta, Almada
Centro Hospitalar E Universitário de Coimbra EPE, Coimbra
Hospital Senhora da Oliveira - Guimaraes, E.P.E, Guimarães
Centro Hospitalar Lisboa Norte, E.P.E. - Hospital de Santa Maria, Lisbon
Unidade Local de Saúde de Matosinhos SA, Matosinhos Municipality
Centro Hospitalar do Porto EPE, Porto
Instituto Portugues de Oncologia Do Porto Francisco Gentil Epe - PPDS, Porto
Fundeni Clinical Institute, Bucharest
Wilgers Oncology Centre, Pretoria
Korea University Anam Hospital, Seoul
Seoul National University Hospital, Seoul
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul
Kangbuk Samsung Hospital, Seoul
Severance Hospital Yonsei University Health System - PPDS, Seoul
Asan Medical Center, Seoul
Gangnam Severance Hospital, Yonsei University Health System, Seoul
Samsung Medical Center, Seoul
Korea University Guro Hospital, Seoul
Corporacio Sanitaria Parc Tauli, Sabadell
Hospital Universitario Vall d'Hebron - PPDS, Barcelona
Institut Català d'Oncologia (Hospital Duran y Reynals), L'Hospitalet de Llobregat
Hacettepe Universitesi Kanser Enstitusu, Ankara
Acibadem Adana Hospital, Seyhan
Dr. Abdurrahman Yurtaslan Ankara Onkology Training and Research Hospital, Yenimahalle
Bristol Haematology and Oncology Centre, Bristol
Western General Hospital Edinburgh - PPDS, Edinburgh
St James University Hospital, Leeds
Guy's and St Thomas' NHS Foundation Trust - Guy's Hospital, London
Royal Marsden Hospital - London, London
Royal Marsden Hospital - Surrey, London
Edith Cavell Hospital, Peterborough
Weston Park Cancer Centre, Sheffield
Lead Sponsor
Collaborators (2)
BeOne Medicines LTD
UNKNOWN
BeOne Pharmaceutical Co., Ltd.
UNKNOWN
Jazz Pharmaceuticals
INDUSTRY