An Attempt at Translating Novelty-enhanced Extinction of Context Conditioning From Rodents to Humans

NACompletedINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

November 15, 2021

Primary Completion Date

May 1, 2022

Study Completion Date

May 1, 2022

Conditions
Healthy
Interventions
BEHAVIORAL

Novel Exploration

Exploration of a novel 3D-environment in virtual reality.

BEHAVIORAL

Threat conditioning

Session 1. Threat conditioning to two different (CS+, CS-) virtual reality contexts (i.e rooms). One of these is paired with a mild electric shock. The context paired with the electric shock (CS+) is counterbalanced across participants. Participants are instructed that they may receive electrical shocks during the procedure.

BEHAVIORAL

Extinction

Session 2. Participants are repeatedly exposed to the both contexts from session 1 (CS+, CS-), but no shocks are delivered.

BEHAVIORAL

Reinstatement

Session 3. Participants are again repeatedly exposed to both contexts from session 1 (CS+, CS-), after a few shocks delivered in a neutral context.

BEHAVIORAL

Visual attention control task

Session 2. A visual attention task used as a control task instead of novel exploration.

Trial Locations (1)

75142

Uppsala University, deparmtent of Psychology, Uppsala

All Listed Sponsors
lead

Uppsala University

OTHER

NCT05150951 - An Attempt at Translating Novelty-enhanced Extinction of Context Conditioning From Rodents to Humans | Biotech Hunter | Biotech Hunter