Goal-directed Hemodynamic Management and Kidney Injury After Radical Nephrectomy or Nephroureterectomy

NARecruitingINTERVENTIONAL
Enrollment

1,724

Participants

Timeline

Start Date

February 10, 2025

Primary Completion Date

December 30, 2032

Study Completion Date

December 30, 2034

Conditions
NephrectomyNephroureterectomyHemodynamic ManagementAcute Kidney InjuryChronic Kidney Diseases
Interventions
OTHER

Targeted hemodynamic management

"During anesthesia, hemodynamic managements include active hydration (\>10 ml/kg/h), use of inotropes (dobutamine), and forced diuresis; the targets are to maintain pulse pressure variation \<9%, mean arterial pressure ≥85 mmHg, and urine output \>200 ml/h (3ml/kg/h).~During the first 48 hours after surgery, systolic blood pressure is maintained ≥110 mmHg or within 20% of baseline by delaying antihypertensive resumption, providing fluid challenge, and/or vasoactive infusion."

OTHER

Routine care

"During anesthesia, hemodynamic managements are conducted according to routine practice and usually include fluid infusion at a rate of 6-8 ml/kg/h without inotropics; the targets are to maintain mean arterial pressure ≥60 mmHg and urine output \>0.5 ml/kg/h.~During the first 48 hours after surgery, hemodynamic management is performed according to routine practice."

Trial Locations (1)

100034

RECRUITING

Beijing University First Hospital, Beijing

All Listed Sponsors
lead

Peking University First Hospital

OTHER