Stereotactic Radiosurgery vs Whole Brain Radiotherapy in Breast Cancer With Brain Oligometastasis

PHASE3RecruitingINTERVENTIONAL
Enrollment

98

Participants

Timeline

Start Date

August 31, 2021

Primary Completion Date

December 31, 2023

Study Completion Date

March 31, 2024

Conditions
Breast CancerBrain Metastases, AdultStereotactic RadiosurgeryWhole Brain Radiotherapy
Interventions
RADIATION

Stereotactic Radiosurgery

All patients to undergo planning CT simulation with 1mm slice thickness. For all lesions, the gross tumor volume (GTV) will be defined as the visible tumor on CT and/or MRI imaging. A Planning Target Volume (PTV) margin of 2-5 mm will be added. Organs at risk visible in the planning CT scan will be contoured. The doses will be prescribed to approximately 100% isodose level and 95% of the PTV should receive 95% of the prescription dose. Metastases with a maximum diameter of up to 2 cm will be treated with doses of 22 to 25 Gy and those larger than 2 cm will be treated with doses of 18 to 20 Gy.

Trial Locations (1)

160012

RECRUITING

Budhi Singh Yadav, Chandigarh

All Listed Sponsors
lead

Post Graduate Institute of Medical Education and Research, Chandigarh

OTHER