A Study to Evaluate Zilovertamab Vedotin (MK-2140) for Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-004)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

140

Participants

Timeline

Start Date

January 8, 2022

Primary Completion Date

January 9, 2026

Study Completion Date

January 9, 2026

Conditions
Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Interventions
BIOLOGICAL

MK-2140 (zilovertamab vedotin)

IV infusion of 2.5 mg/kg

BIOLOGICAL

MK-2140 (zilovertamab vedotin)

IV infusion of 2.25 mg/kg

Trial Locations (71)

5021

Haukeland Universitetssjukehus ( Site 1601), Bergen

10595

New York Medical College ( Site 0215), Valhalla

10700

Faculty of Medicine Siriraj Hospital ( Site 0701), Bangkok

12808

Vseobecna fakultni nemocnice v Praze-I. Interní klinika - klinika hematologie ( Site 0801), Prague

13419

North Estonia Medical Centre Foundation ( Site 0900), Tallinn

15224

AHN West Penn Hospital ( Site 0212), Pittsburgh

20007

Georgetown University Medical Center ( Site 0204), Washington D.C.

20089

Humanitas-U.O di Oncologia medica ed Ematologia ( Site 1503), Rozzano

20133

Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa di Ematologia ( Site 1501), Milan

21201

University of Maryland-Greenebaum Comprehensive Cancer Center ( Site 0211), Baltimore

22185

Skånes Universitetssjukhus Lund ( Site 2100), Lund

28040

Hospital Universitario Fundación Jiménez Díaz-Oncology & Hematology ( Site 2000), Madrid

30342

Northside Hospital ( Site 0206), Atlanta

34214

Mega Medipol-Hematology ( Site 2308), Istanbul

35340

Dokuz Eylül Üniversitesi-Hematology ( Site 2304), Izmir

37007

Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca ( Site 2003), Salamanca

40138

"IRCCS - AOU di Bologna-Istituto di Ematologia L. e A. Seragnoli ( Site 1500)", Bologna

43210

The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C, Columbus

44106

University Hospitals Cleveland Medical Center ( Site 0222), Cleveland

45219

University of Cincinnati Medical Center-University of Cincinnati Cancer Center ( Site 0217), Cincinnati

46237

Franciscan St. Francis Health ( Site 0225), Indianapolis

48109

University of Michigan ( Site 0200), Ann Arbor

48201

Karmanos Cancer Institute ( Site 0216), Detroit

50200

Maharaj Nakorn Chiang Mai Hospital ( Site 0702), Muang

53226

MEDICAL COLLEGE OF WISCONSIN ( Site 0234), Milwaukee

55139

Ondokuz Mayıs Universitesi ( Site 2306), Samsun

57105

Avera Cancer Institute- Research ( Site 0233), Sioux Falls

60637

University of Chicago Medical Center ( Site 0207), Chicago

61080

Karadeniz Teknik Universitesi Tip Fakultesi-Hematology ( Site 2307), Trabzon

63110

Saint Louis University Cancer Center ( Site 0209), St Louis

64109

Centre Hospitalier de la Côte Basque ( Site 1002), Bayonne

64239

Sourasky Medical Center ( Site 1400), Tel Aviv

75013

Pitie Salpetriere University Hospital-Clinical haematology ( Site 1000), Paris

80131

Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1502), Napoli

90603

Innovative Clinical Research Institute ( Site 0202), Whittier

92868

St. Joseph Hospital-The Center for Cancer Prevention and Treatment ( Site 0229), Orange

100142

Beijing Cancer hospital ( Site 2900), Beijing

130021

The First Hospital of Jilin University-Hematology ( Site 2910), Changchun

200032

Fudan University Shanghai Cancer Center ( Site 2908), Shanghai

200120

Shanghai East Hospital ( Site 2902), Shanghai

300060

Tianjin Medical University Cancer Institute and Hospital-lymphoma ( Site 2901), Tianjin

310003

The First Affiliated Hospital, Zhejiang University-Bone marrow transplant centre ( Site 2912), Hangzhou

410013

Hunan Cancer Hospital ( Site 2905), Changsha

430022

Wuhan Union Hospital ( Site 2906), Wuhan

450008

Henan Cancer Hospital-hematology department ( Site 2903), Zhengzhou

510030

SUN YAT-SEN UNIVERSITY CANCER CENTRE-Internal Medicine ( Site 2907), Guangzhou

610041

West China Hospital of Sichuan University-Head and Neck Oncology ( Site 2911), Chengdu

4800827

James Lind Centro de Investigación del Cáncer ( Site 2705), Temuco

7650568

Clínica Alemana de Santiago ( Site 2704), Santiago

8410101

Soroka Medical Center-Hematology Department ( Site 1403), Beersheba

9103102

Shaare Zedek Medical Center ( Site 1404), Jerusalem

9112001

Hadassah Medical Center ( Site 1402), Jerusalem

02114

Massachusetts General Hospital-Cancer Center Protocol Office ( Site 0203), Boston

07960

Atlantic Health System Morristown Medical Center ( Site 0213), Morristown

M5G 2M9

Princess Margaret Cancer Centre-Division of Medical Oncology and Hematology ( Site 0100), Toronto

625 00

Fakultní nemocnice Brno Bohunice-Interni hematologicka a onkologicka klinika ( Site 0800), Brno

106 76

Evangelismos General Hospital of Athens ( Site 1214), Athens

115 27

"General Hospital of Athens Laiko-Hematology Department ( Site 1213)", Athens

0310

Oslo universitetssykehus, Radiumhospitalet ( Site 1600), Oslo

31-826

Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie-Oncology Department ( Site 1707), Krakow

50-367

Uniwersytecki Szpital Kliniczny-Klinika Hematologii, Nowotworow Krwi i Transplantacji Szpiku ( Site, Wroclaw

02-781

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworów Układu Chłonnego ( S, Warsaw

81-519

Szpitale Pomorskie Sp. z o. o.-Hematology and Bone Marrow Transplantation Department ( Site 1702), Gdynia

40-519

Pratia Onkologia ( Site 1701), Katowice

03722

Severance Hospital, Yonsei University Health System-Medical oncology ( Site 0601), Seoul

06351

Samsung Medical Center ( Site 0600), Seoul

08908

Instituto Catalan de Oncologia - Hospital Duran i Reynals-Haematology Department ( Site 2002), L'Hospitalet Del Llobregat

08035

Hospital Universitari Vall d'Hebron ( Site 2005), Barcelona

171 64

Karolinska Universitetssjukhuset Solna ( Site 2102), Solna

06100

Ankara University Hospital Cebeci-hematology ( Site 2300), Ankara

06230

Hacettepe Universitesi-Department of Hematology ( Site 2302), Ankara

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY