Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer

PHASE1RecruitingINTERVENTIONAL
Enrollment

280

Participants

Timeline

Start Date

June 17, 2022

Primary Completion Date

February 28, 2030

Study Completion Date

November 30, 2031

Conditions
Non-Small Cell Lung Cancer
Interventions
BIOLOGICAL

BNT116

Intravenous injection

BIOLOGICAL

Cemiplimab

Intravenous infusion

DRUG

Docetaxel

Intravenous infusion

DRUG

Carboplatin

Intravenous infusion

DRUG

Paclitaxel

Intravenous infusion

BIOLOGICAL

BNT316

Intravenous infusion

BIOLOGICAL

anti-B7-H3 antibody conjugated to topoisomerase I inhibitor

Intravenous infusion

BIOLOGICAL

anti-HER3 antibody conjugated to topoisomerase I inhibitor

Intravenous infusion

BIOLOGICAL

Bispecific antibody for PD-L1 and VEGF-A

Intravenous infusion

Trial Locations (45)

1077

COMPLETED

ICON-PRA Budapest, Fázis 1 Vizsgálóhely, Budapest

1083

RECRUITING

Semmelweis Egyetem ÁOK Belgyógyászati és Onkológiai Klinika, Budapest

1122

RECRUITING

National Institute of Oncology, Budapest

2031

RECRUITING

Scientia Clinical Research, Randwick

2065

RECRUITING

Royal North Shore Hospital, Sydney

3168

RECRUITING

Monash Health, Clayton

3200

RECRUITING

Clinexpert Ltd, Gyöngyös

5000

RECRUITING

Cancer Research SA, Adelaide

15706

RECRUITING

Complejo Hospitalario Universitario de Santiago de Compostela (CHUS) - Hospital Clinico Universitario (University Clinical Hospital), Santiago de Compostela

20246

RECRUITING

University Medical Center Hamburg-Eppendorf, Hamburg

21287

RECRUITING

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore

22031

RECRUITING

NEXT Virginia, Fairfax

28033

RECRUITING

MD Anderson Cancer Center, Madrid

28040

RECRUITING

Hospital Universitario Fundacion Jimenez Diaz, Madrid

28050

RECRUITING

START Madrid - CIOCC. Grupo Hospital de Madrid (HM) - Centro Integral Oncologico Clara Campal (CIOCC), Madrid

34010

RECRUITING

Koc University Hospital, Istanbul

34093

NOT_YET_RECRUITING

University Medical Faculty Oncology Institute, Istanbul

34718

RECRUITING

Yeditepe University, Istanbul

35100

RECRUITING

Ege University School of Medicine Tulay Aktas Oncology Hospital, Izmir

35330

COMPLETED

Dokuz Eylul Medical School, Izmir

40202

RECRUITING

Norton Cancer Institute, Louisville

40536

RECRUITING

University of Kentucky Chandler Medical Center, Lexington

41009

RECRUITING

Hospital Universitario Virgen Macarena, Seville

46026

RECRUITING

Hospital Universitario y Politecnico La Fe, Valencia

50937

RECRUITING

Universitätsklinikum Köln, Cologne

55131

RECRUITING

Universitaetsmedizin der Johannes Gutenberg Universitaet Mainz KoeR, Mainz

60488

RECRUITING

Krankenhaus Nordwest GmbH - Institut Fuer Klinisch-Onkologische Forschung (IKF), Frankfurt

77030

RECRUITING

MD Anderson Cancer Center, Houston

80-214

RECRUITING

Uniwersyteckie Centrum Kliniczne, Gdansk

10-357

RECRUITING

Warminsko Mazurskie Centrum Chorob Pluc w Olsztynie, Olsztyn

60-693

RECRUITING

NZOZ Medpolonia Sp. Z o.o, Poznan

02-781

WITHDRAWN

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy, Warsaw

08916

RECRUITING

Institut Catala d'Oncologia Badalona, Hospital Germans Trias I Pujol, Badalona

08035

RECRUITING

Hospital Universitario Vall d'Hebron, Barcelona

01230

NOT_YET_RECRUITING

Adana Sehir Hospital, Adana

06100

RECRUITING

Haceteppe Hospital, Ankara

06200

RECRUITING

Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara

06800

RECRUITING

Ankara City Hospital, Ankara

01370

RECRUITING

Adana Sehir Hospital, Yüreğir

CB2 0QQ

RECRUITING

Cambridge University Hospitals NHS Foundation Trust, Cambridge

CF14 2TL

RECRUITING

Velindre NHS Trust, Cardiff

L7 8YA

RECRUITING

The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool

SE1 9RT

RECRUITING

Guy's and St Thomas NHS Foundation Trust, London

W1T 7HA

RECRUITING

University College London Hospitals NHS Foundation Trust, London

NE7 7DN

RECRUITING

The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne

Sponsors

Lead Sponsor

All Listed Sponsors
lead

BioNTech SE

INDUSTRY