360
Participants
Start Date
August 1, 2022
Primary Completion Date
August 5, 2024
Study Completion Date
August 5, 2024
infants receive primary non-invasive respiratory support by mean of nCPAP
neonates assigned to the nCPAP group will be started on a pressure of 6 cmH2O( adjust range:6-10 cmH2O) , with FiO2 (0.21-0.40)adjusted to target SpO2 from 89% to 94%. CPAP will be provided by either variable flow or continuous flow devices, as there is no clear evidence that one type of CPAP generator would be better than any other by pure CPAP system.
infants receive primary non-invasive respiratory support by mean of NHFOV
neonates assigned to NHFOV will be started with the following boundaries: a) Paw of 6 cmH2O (the range 6-10 cmH2O); b) frequency of 10 Hz (the range 8-12 Hz). c) Inspiratory time 50% (1:1). d) amplitude 15 cmH2O(the range 15-25 cmH2O) NHFOV will only be provided with piston/ membrane oscillators able to provide an active expiratory phase (that is, Acutronic FABIAN-III, SLE 5000, Loweinstein Med LEONI+, Sensormedics 3100A).
Hunan Provincial Maternal and Child Health Care Hospital, Changsha
The Second Hospital of Shandong University, Jinan
Qujing Maternity and cChild Healthcare Hospital, Qujing
Jiangxi Maternal and Child Health Hospital
OTHER
Children's Hospital of Chongqing Medical University
OTHER
Guiyang Maternity and Child Health Care Hospital
OTHER
The Second Hospital of Shandong University
OTHER
Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region
OTHER
Hunan Provincial Maternal and Child Health Care Hospital
OTHER
Zhangzhou Affiliated Hospital of Fujian Medical University
OTHER
Women and Children's Health Hospital of Yulin
OTHER
Chongqing Three Gorges Central Hospital
OTHER
Gansu Provincial Maternal and Child Health Care Hospital
OTHER
The First People's Hospital of Yunnan
OTHER
Chengdu Women's and Children's Central Hospital
OTHER
Maternal and Children's Healthcare Hospital of Taian
OTHER
People's Hospital of Xinjiang Uygur Autonomous Region
OTHER
Quanzhou Children's Hospital
OTHER
Chongqing West Hospital
OTHER
Chongqing Medical Center for Women and Children
OTHER
Xiamen Maternity & Child Care Hospital
OTHER
Qujing Maternal and Child Health Hospital
OTHER
Liuzhou Maternity and Child Healthcare Hospital
OTHER
International Peace Maternity and Child Health Hospital
OTHER
Jiulongpo No.1 People's Hospital
OTHER