Effects of Combination Medical Therapy Followed by BPA on Right Ventricular-PA Coupling and Hemodynamics in CTEPH

PHASE3RecruitingINTERVENTIONAL

Enrollment

Participants

Timeline

Start Date

January 27, 2025

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2026

Conditions

CTEPH

Interventions

DRUG

Macitentan Tablets

10 mg oral once daily

DRUG

Riociguat

1 mg to 2.5mg oral three times daily

DEVICE

balloon pulmonary angioplasty

on hemodynamics and RV function (including advanced assessments of RV-PA coupling

Trial Locations (1)

RECRUITING

Duke University Medical Center, Durham

All Listed Sponsors

collaborator

Janssen Pharmaceutica N.V., Belgium

INDUSTRY

lead

Dr Sudarshan Rajagopal

OTHER