VAsopressin and STeroids in Addition to Adrenaline in Cardiac Arrest - a Randomized Clinical Trial

PHASE3RecruitingINTERVENTIONAL
Enrollment

1,276

Participants

Timeline

Start Date

November 17, 2021

Primary Completion Date

January 31, 2027

Study Completion Date

April 30, 2027

Conditions
Cardiac Arrest;In-hospital Cardiac Arrest; Methylprednisolone; Vasopressin; Adrenaline; Randomized Clinical Trial
Interventions
DRUG

Vasopressin; Methylprednisolone; Hydrocortisone

"Vasopressin, the vasoconstrictive hypophysal hormone, alone has not shown increased survival when compared to adrenaline. However, animal data have shown increased diastolic pressure, cerebral perfusion pressure and cerebral oxygenation in cardiac arrest treatment with vasopressin, and have when compared to adrenaline been associated with better cerebral blood flow.~Corticosteroids are currently used in septic shock treatment as a means to reduce time to shock reversal and thereby potentially improving mortality. Steroids have therefore also been suggested for cardiac arrest treatment. The potential role in resuscitation includes the catecholaminerg potentiation, vasoconstriction and protection from reperfusion injury."

DRUG

Sodium chloride

Sodium chloride 9 mg/ml

Trial Locations (2)

Unknown

RECRUITING

Sahlgrenska University Hospital, Gothenburg

RECRUITING

Tiohundra, Norrtälje

All Listed Sponsors
collaborator

Sahlgrenska University Hospital

OTHER

collaborator

Stockholm South General Hospital

OTHER

lead

Tiohundra AB

INDUSTRY