A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

290

Participants

Timeline

Start Date

January 14, 2022

Primary Completion Date

September 24, 2027

Study Completion Date

September 24, 2027

Conditions
DLBCLDiffuse Large B-Cell Lymphoma
Interventions
BIOLOGICAL

Zilovertamab vedotin

Intravenous (IV) Infusion 1.5 mg/kg, 1.75 mg/kg, 2.0 mg/kg, 2.25 mg/kg, 2.5 mg/kg

BIOLOGICAL

Rituximab

IV Infusion 375 mg/m\^2

DRUG

Gemcitabine

IV Infusion 1000 mg/m\^2

DRUG

Oxaliplatin

IV Infusion 100 mg/m\^2

DRUG

Bendamustine

IV Infusion 90 mg/m\^2

DRUG

Granulocyte Colony-Stimulating Factor (G-CSF)

Prophylactic G-CSF will be administered at each cycle of zilovertamab vedotin as per the institutional guidelines.

Trial Locations (113)

1010

RECRUITING

CELAN,S.A ( Site 2603), Guatemala City

2025

RECRUITING

Aotearoa Clinical Trials ( Site 0501), Auckland

3350

RECRUITING

Grampians Health ( Site 1802), Ballarat

4814

RECRUITING

Townsville University Hospital ( Site 1800), Douglas

6000

RECRUITING

Royal Perth Hospital-Haematology ( Site 1801), Perth

10103

RECRUITING

CIMCA ( Site 2501), San José

10330

ACTIVE_NOT_RECRUITING

Chulalongkorn University ( Site 0402), Pathumwan

10595

RECRUITING

New York Medical College ( Site 0113), Valhalla

10700

ACTIVE_NOT_RECRUITING

Faculty of Medicine Siriraj Hospital-Division of Hematology, Department of Medicine ( Site 0400), Bangkok

10903

RECRUITING

Hospital Metropolitano - Sede Lindora ( Site 2500), Santa Ana

14001

RECRUITING

Clínicas AUNA Sede Chiclayo ( Site 2803), Chiclayo

15072

RECRUITING

Clínica San Felipe ( Site 2805), Lima

RECRUITING

Hospital Nacional Edgardo Rebagliati Martins ( Site 2802), Lima

15087

RECRUITING

Hospital Nacional Dos De Mayo ( Site 2804), Lima

18009

RECRUITING

MNPE ClinCenter of Oncology,Hematology,Transplantology and Palliative Care of CherkasyRegCouncil ( Site 2000), Cherkasy

20089

RECRUITING

Humanitas-U.O di Oncologia medica ed Ematologia ( Site 1203), Rozzano

21201

RECRUITING

University of Maryland ( Site 0123), Baltimore

24014

RECRUITING

Blue Ridge Cancer Care ( Site 0169), Roanoke

31203

RECRUITING

Medivest Centro de Investigación Integral ( Site 2704), Chihuahua City

33486

RECRUITING

Boca Raton Regional Hospital- Lynn Cancer Institute ( Site 0163), Boca Raton

34214

RECRUITING

Mega Medipol-Hematology ( Site 1909), Istanbul

34711

RECRUITING

Clermont Oncology Center ( Site 0174), Clermont

35100

RECRUITING

Ege University Medicine of Faculty ( Site 1902), Bornova

35340

RECRUITING

Dokuz Eylül Üniversitesi-Hematology ( Site 1905), Izmir

37232

COMPLETED

Vanderbilt University Medical Center-Vanderbilt-Ingram Cancer Center ( Site 0156), Nashville

40138

COMPLETED

"IRCCS - AOU di Bologna-Istituto di Ematologia L. e A. Seragnoli ( Site 1200)", Bologna

40207

RECRUITING

Norton Women's and Children's Hospital-Norton Cancer Institute - St. Matthews ( Site 0133), Louisville

40536

RECRUITING

University of Kentucky Chandler Medical Center ( Site 0158), Lexington

41017

RECRUITING

Saint Elizabeth Medical Center Edgewood ( Site 0165), Edgewood

50034

RECRUITING

Hospital Pablo Tobon Uribe ( Site 0804), Medellín

50200

ACTIVE_NOT_RECRUITING

Maharaj Nakorn Chiang Mai Hospital ( Site 0401), Chiang Mai

55139

COMPLETED

Ondokuz Mayıs Universitesi ( Site 1907), Samsun

59102

RECRUITING

St. Vincent Frontier Cancer Center-Research ( Site 0108), Billings

69310

ACTIVE_NOT_RECRUITING

centre hospitalier lyon sud-Service Hématologie ( Site 0702), Pierre-Bénite

70112

COMPLETED

Louisiana State University Health Sciences Center New Orleans ( Site 0134), New Orleans

75013

RECRUITING

Pitie Salpetriere University Hospital-Clinical haematology ( Site 0700), Paris

76008

RECRUITING

"Communal non-profit enterprise Regional clinical hospital of Ivano-Frankivsk Regional Council ( Site 2004)", Ivano-Frankivsk

79057

RECRUITING

Institute of Blood Pathology and Transfusion Medicine AMS Ukraine ( Site 2002), Lviv

80131

RECRUITING

Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1202), Napoli

89169

RECRUITING

Comprehensive Cancer Centers of Nevada ( Site 0168), Las Vegas

90603

COMPLETED

Innovative Clinical Research Institute ( Site 0122), Whittier

94598

RECRUITING

Bass Medical Group ( Site 0166), Walnut Creek

100142

RECRUITING

Beijing Cancer hospital ( Site 3000), Beijing

110131

RECRUITING

FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0801), Bogotá

130021

RECRUITING

The First Hospital of Jilin University-Hematology ( Site 3012), Changchun

200032

RECRUITING

Fudan University Shanghai Cancer Center ( Site 3009), Shanghai

230002

RECRUITING

Instituto Médico de Alta Tecnologia S.A.S ( Site 0803), Montería

310000

RECRUITING

Zhejiang Cancer Hospital ( Site 3014), Hangzhou

310003

RECRUITING

The First Affiliated Hospital Zhejiang University School of Medicine ( Site 3027), Hangzhou

330006

RECRUITING

The First Affiliated Hospital of Nanchang University ( Site 3004), Nanchang

330029

RECRUITING

Jiangxi Provincial Cancer Hospital ( Site 3005), Nanchang

400030

RECRUITING

Chongqing University Cancer Hospital-Medical Oncology ( Site 3025), Chongqing

404199

ACTIVE_NOT_RECRUITING

Chongqing University Three Gorges Hospital ( Site 3026), Chongqing

430048

RECRUITING

Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 3017), Wuhan

450008

RECRUITING

Henan Cancer Hospital-hematology department ( Site 3013), Zhengzhou

471003

RECRUITING

The First Affiliated Hospital of Henan University of Science &Technology ( Site 3029), Luoyang

510060

RECRUITING

Sun Yat-sen University Cancer Center-Internal Medicine ( Site 3001), Guangzhou

510280

RECRUITING

Zhujiang Hospital ( Site 3002), Guangzhou

610041

RECRUITING

West China Hospital of Sichuan University-Head and Neck Oncology ( Site 3016), Chengdu

610042

RECRUITING

Sichuan Cancer hospital-Oncology ( Site 3021), Chengdu

660001

RECRUITING

Oncologos del Occidente ( Site 0800), Pereira

760032

RECRUITING

Fundacion Valle del Lili ( Site 0802), Santiago de Cali

1720430

RECRUITING

IC La Serena Research ( Site 2405), La Serena

1834111

COMPLETED

Emek Medical Center-Hematology Unit ( Site 1102), Afula

3436212

COMPLETED

Carmel Hospital ( Site 1103), Haifa

4070196

RECRUITING

Biocenter ( Site 2401), Concepción

5112129

RECRUITING

Oncocentro Valdivia ( Site 2407), Valdivia

7500921

RECRUITING

FALP-UIDO ( Site 2400), Santiago

7580206

RECRUITING

Clínica Inmunocel ( Site 2404), Santiago

7650018

RECRUITING

Clínica RedSalud Vitacura ( Site 2409), Santiago

8420383

RECRUITING

Bradfordhill ( Site 2403), Santiago

9112001

COMPLETED

Hadassah Medical Center ( Site 1100), Jerusalem

02215

RECRUITING

Dana-Farber Cancer Institute-Lymphoma ( Site 0111), Boston

01655

RECRUITING

University of Massachusetts Medical School ( Site 0119), Worcester

07960

RECRUITING

Atlantic Health System ( Site 0116), Morristown

C1199ABB

RECRUITING

Hospital Italiano de Buenos Aires ( Site 2203), Ciudad Autonoma de Buenos Aires

B7600FZO

RECRUITING

Instituto de Investigaciones Clínicas Mar del Plata ( Site 2205), Mar del Plata

C1118AAT

RECRUITING

Hospital Aleman ( Site 2200), Buenos Aites

C1426ANZ

RECRUITING

Instituto Alexander Fleming ( Site 2201), CABA

X5016KEH

RECRUITING

Hospital Privado Universitario de Córdoba ( Site 2202), Córdoba

81520-060

RECRUITING

Hospital Erasto Gaertner ( Site 2302), Curitiba

59062-000

RECRUITING

Liga Norte Riograndense Contra o Câncer ( Site 2305), Natal

01321-001

RECRUITING

Hospital Paulistano ( Site 2300), São Paulo

05403-010

RECRUITING

Pesquisa Clínica do Serviço de Hematologia do Hospital das Clínicas da FMUSP ( Site 2306), São Paulo

M5G 2M9

COMPLETED

Princess Margaret Cancer Centre-Division of Medical Oncology and Hematology ( Site 0200), Toronto

106 76

RECRUITING

Evangelismos General Hospital of Athens ( Site 0900), Athens

115 26

RECRUITING

"Regional General Hospital of Athens Laiko ( Site 0901)", Athens

681 00

RECRUITING

University Hospital of Alexandroupolis ( Site 0903), Alexandroupoli

01009

RECRUITING

MEDI-K ( Site 2602), Guatemala City

01010

RECRUITING

Private Practice- Dr. Rixci Augusto Lenin Ramírez ( Site 2601), Guatemala City

000000

RECRUITING

Queen Mary Hospital ( Site 3100), Hong Kong

Unknown

RECRUITING

Princess Margaret Hospital ( Site 3101), Hong Kong

00168

COMPLETED

Fondazione Policlinico Universitario Agostino Gemelli IRCCS -ISTITUTO DI EMATOLOGIA ( Site 1204), Roma

03100

RECRUITING

Health Pharma Professional Research S.A. de C.V: ( Site 2700), Mexico City

03104

RECRUITING

Centro de Infusion Superare ( Site 2701), Mexico City

30-727

RECRUITING

Pratia MCM Krakow ( Site 1303), Krakow

58-309

RECRUITING

Specjalistyczny Szpital im. Dr Alfreda Sokolowskiego w Walbrzychu ( Site 1305), Wałbrzych

50-367

COMPLETED

Uniwersytecki Szpital Kliniczny-Klinika Hematologii, Nowotworow Krwi i Transplantacji Szpiku ( Site 1301), Wroclaw

20-090

COMPLETED

Centrum Onkologii Ziemi Lubelskiej-Oddzial Hematologii i Transplantacji Szpiku ( Site 1304), Lublin

02-781

RECRUITING

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworów Układu Chłonnego ( Site 1300), Warsaw

81-519

COMPLETED

Szpitale Pomorskie Sp. z o. o.-Hematology and Bone Marrow Transplantation Department ( Site 1302), Gdynia

76-200

RECRUITING

Wojewódzki Szpital Specjalistyczny im. J. Korczaka w Słupsku ( Site 1309), Słupsk

40-519

RECRUITING

Pratia Onkologia Katowice ( Site 1306), Katowice

03080

RECRUITING

Seoul National University Hospital-Oncology ( Site 0302), Seoul

06351

RECRUITING

Samsung Medical Center ( Site 0300), Seoul

06200

RECRUITING

Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi ( Site 1912), Yenimahalle

06100

RECRUITING

Ankara University Hospital Cebeci-hematology ( Site 1901), Ankara

03022

RECRUITING

State non-profit enterprise National Cancer Institute ( Site 2001), Kyiv

03115

RECRUITING

National Research Center for Radiation Medicine of National Academy of Medical Sciences of Ukraine ( Site 2005), Kyiv

04112

RECRUITING

Public Non-Profit Enterprise Kyiv City Clinical Hospital #9 under the Executive Body of Kyiv City Co ( Site 2003), Kyiv

AB25 2ZN

RECRUITING

Aberdeen Royal Infirmary ( Site 2104), Aberdeen

TR1 3LJ

RECRUITING

The Royal Cornwall Hospital ( Site 2103), Truro

NW1 2PG

RECRUITING

University College London Hospital-Cancer Clinical Trials Unit ( Site 2100), London-Camden

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY