Staphylococcus Aureus Network Adaptive Platform Trial

PHASE4RecruitingINTERVENTIONAL
Enrollment

8,000

Participants

Timeline

Start Date

February 16, 2022

Primary Completion Date

December 1, 2028

Study Completion Date

December 1, 2028

Conditions
Staphylococcus Aureus Bacteremia
Interventions
DRUG

Cefazolin

Cefazolin

DRUG

Penicillin

benzylpenicillin

DRUG

Clindamycin

Clindamycin

DRUG

Vancomycin

Vancomycin or Daptomycin

OTHER

Effectiveness of early switch to oral antibiotics

This involves testing a strategy rather than individual antibiotic agents

RADIATION

Whole body FDG PET/CT Imaging

Whole body FDG PET/CT imaging will be performed using a standardised protocol describing patient preparation and minimum specifications for radiopharmaceutical production, quality control, and PET/CT acquisition.

Trial Locations (151)

1023

RECRUITING

Auckland City Hospital, Grafton

RECRUITING

Starship Hospital, Auckland

1640

RECRUITING

Middlemore Hospital, Otahuhu

2010

RECRUITING

St Vincent's Hospital Sydney, Darlinghurst

2025

RECRUITING

KidzFirst, Auckland

2031

RECRUITING

Prince of Wales Hospital, Randwick

RECRUITING

Sydney Children's Hospital, Randwick

2050

RECRUITING

Royal Prince Alfred Hospital, Camperdown

2139

RECRUITING

Concord Repatriation and General Hospital, Concord

2145

RECRUITING

The Children's Hospital at Westmead, Westmead

RECRUITING

Westmead Hospital, Westmead

2148

RECRUITING

Blacktown Hospital, Blacktown

2170

RECRUITING

Liverpool Hospital, Liverpool

2217

NOT_YET_RECRUITING

St George Hospital, Kogarah

2305

RECRUITING

John Hunter Hospital, New Lambton Heights

RECRUITING

John Hunter Children's Hospital, Newcastle

2500

RECRUITING

Wollongong Hospital, Wollongong

2605

RECRUITING

Canberra Hospital, Garran

2747

RECRUITING

Nepean Hospital, Kingswood

2800

RECRUITING

Orange Health Service, Orange

3004

RECRUITING

Alfred Hospital, Melbourne

3011

RECRUITING

Western Health - Footscray, Joan Kirner & Sunshine Hospitals, Footscray

3050

RECRUITING

Royal Melbourne Hospital, Parkville

3052

RECRUITING

Royal Children's Hospital Melbourne, Parkville

3084

RECRUITING

Austin Hospital, Heidelberg

3112

RECRUITING

Tauranga Hospital, Tauranga

3128

RECRUITING

Box Hill Hospital, Box Hill

3168

NOT_YET_RECRUITING

Monash Children's Hospital, Clayton

RECRUITING

Monash Health - Monash Medical Centre & Jesse McPherson Private Hospital, Clayton

3199

NOT_YET_RECRUITING

Frankston Hospital, Frankston

3220

RECRUITING

Barwon Health - University Hospital Geelong, Geelong

3240

RECRUITING

Waikato Hospital, Hamilton

3350

RECRUITING

Grampians Health, Ballarat

3550

RECRUITING

Bendigo Health, Bendigo

3630

COMPLETED

Goulburn Valley Health, Shepparton

3844

NOT_YET_RECRUITING

La Trobe Regional Hospital, Traralgon

4020

RECRUITING

Redcliffe Hospital, Redcliffe

4029

RECRUITING

Royal Brisbane and Women's Hospital, Herston

4101

RECRUITING

Queensland Children's Hospital, South Brisbane

4102

NOT_YET_RECRUITING

Princess Alexandra Hospital, Woolloongabba

4131

NOT_YET_RECRUITING

Logan Hospital, Meadowbrook

4215

RECRUITING

Gold Coast University Hospital, Southport

4226

RECRUITING

Robina Hospital, Robina

4305

RECRUITING

Ipswich Hospital, Ipswich

4575

RECRUITING

Sunshine Coast University Hospital, Birtinya

4870

RECRUITING

Cairns Hospital, Cairns

5006

NOT_YET_RECRUITING

Women and Children's Hospital, North Adelaide

NOT_YET_RECRUITING

Women's and Children's Hospital, North Adelaide

5010

RECRUITING

Hutt Valley Hospital, Boulcott

5042

RECRUITING

Flinders Medical Centre, Bedford Park

5112

RECRUITING

Lyell McEwin Hospital, Adelaide

6000

RECRUITING

Royal Perth Hospital, Perth

6009

RECRUITING

Perth Children's Hospital, Nedlands

6021

RECRUITING

Wellington Hospital, Newtown

6112

RECRUITING

Armadale Hospital, Perth

6150

RECRUITING

Fiona Stanley Hospital, Murdoch

7000

NOT_YET_RECRUITING

Royal Hobart Hospital, Hobart

7250

RECRUITING

Launceston Hospital, Launceston

8011

NOT_YET_RECRUITING

Christchurch Hospital, Christchurch

49100

RECRUITING

Beilinson Hospital, Petah Tikva

RECRUITING

Sheba Medical Centre, Ramat Gan

77030

NOT_YET_RECRUITING

Houston Methodist Research Institute, Houston

119228

RECRUITING

National University Hospital, Singapore

168753

RECRUITING

Singapore General Hospital, Singapore

308433

RECRUITING

Tan Tock Seng Hospital, Singapore

310960

RECRUITING

Rambam Health Care Campus, Haifa

0811

RECRUITING

Royal Darwin Hospital, Tiwi

T1Y 6J4

RECRUITING

Peter Lougheed Centre, Calgary

T2N4Z6

RECRUITING

Foothills Medical Center, Calgary

T2V 1P9

RECRUITING

Rockyview Hospital, Calgary

T3M 1M4

RECRUITING

South Health Campus, Calgary

T6G2B7

RECRUITING

University of Alberta Hospital, Edmonton

V6X1A2

RECRUITING

Richmond Hospital, Richmond

Unknown

RECRUITING

Fraser Health Authority - Surrey Memorial Hospital, Surrey

RECRUITING

Eastern Regional Health Authority - St. Clare's Mercy Hospital, St. John's

RECRUITING

Hamilton Health Sciences - Juravinski Hospital, Hamilton

COMPLETED

London Health Sciences Centre - University Hospital, LHSC, London

RECRUITING

Niagara Health - Niagara Falls Site, Niagara Falls

RECRUITING

The Ottawa Hospital - General Campus, Ottawa

RECRUITING

Unity Health Toronto - St Joseph's Health Centre, Toronto

RECRUITING

University Health Network - Toronto Western Hospital, Toronto

RECRUITING

CISSS - Hôpital Cité-de-la-Santé Hospital, Laval

NOT_YET_RECRUITING

McGill University Health Centre - Montreal Children's Hospital, Montreal

RECRUITING

McGill University Health Centre - Royal Victoria Hospital, Montreal

RECRUITING

University of Sherbrooke Health Centre - Hotel Dieu, Sherbrooke

RECRUITING

Schneider Hospital, Petah Tikva

RECRUITING

Jeroen Bosch Hospital, 's-Hertogenbosch

RECRUITING

UMC Groningen, Groningen

RECRUITING

Antonius Ziekenhuis, Nieuwegein

RECRUITING

Radboud University Medical Center, Nijmegen

RECRUITING

Ikazia Ziekenhuis, Rotterdam

RECRUITING

University Medical Center Utrecht, Utrecht

NOT_YET_RECRUITING

Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg

RECRUITING

Helen Joseph Hospital, Johannesburg

NOT_YET_RECRUITING

Rahima Moosa Mother and Child Hospital, Johannesburg

NOT_YET_RECRUITING

NHS Grampian, Aberdeen

RECRUITING

University Hospitals Birmingham, Birmingham

RECRUITING

Brighton and Sussex University Hospitals, Brighton

RECRUITING

North Bristol, Bristol

RECRUITING

University Hospitals Bristol and Weston, Bristol

NOT_YET_RECRUITING

Cambridge University Hospitals, Cambridge

RECRUITING

Cardiff and Vale University, Cardiff

NOT_YET_RECRUITING

Royal Cornwall Hospitals, Cornwall

NOT_YET_RECRUITING

Royal Devon University Healthcare, Devon

NOT_YET_RECRUITING

NHS Tayside, Dundee

RECRUITING

Lothian Western General, Edinburgh

NOT_YET_RECRUITING

Greater Glasgow and Clyde, Glasgow

NOT_YET_RECRUITING

NHS Golden Jubilee, Glasgow

RECRUITING

Hull University Teaching Hospitals, Hull

RECRUITING

Leeds Teaching Hospitals, Leeds

RECRUITING

Liverpool University Hospital, Liverpool

RECRUITING

Barts Health, London

NOT_YET_RECRUITING

Great Ormond Street, London

RECRUITING

Guys and St Thomas', London

RECRUITING

Imperial College Healthcare, London

NOT_YET_RECRUITING

Kings College Hospital, London

RECRUITING

Royal Free London, London

RECRUITING

University College London Hospitals, London

RECRUITING

Whittington Health, London

RECRUITING

Manchester University Hospitals, Manchester

RECRUITING

Newcastle Upon Tyne Hospitals, Newcastle upon Tyne

NOT_YET_RECRUITING

Nottingham University Hospitals, Nottingham

RECRUITING

Oxford University Hospitals, Oxford

NOT_YET_RECRUITING

Sheffield Teaching Hospitals, Sheffield

RECRUITING

South Tees Hospitals, South Tees

RECRUITING

University Hospital Southampton, Southampton

NOT_YET_RECRUITING

NHS Forth Valley, Stirling

NOT_YET_RECRUITING

University Hospitals of North Midlands, Stoke

RECRUITING

Swansea Bay University Health Board, Swansea

V5Z1M9

RECRUITING

Vancouver General Hospital, Vancouver

R2H 2A6

RECRUITING

St. Boniface Hospital, Winnipeg

R3A1R9

RECRUITING

Health Sciences Centre Winnipeg, Winnipeg

R3J 3M7

RECRUITING

Grace Hospital, Winnipeg

A1B3V6

RECRUITING

Eastern Health - Health Sciences Centre (Memorial University), St. John's

M4C3E7

RECRUITING

Toronto East Health Network - Michael Garron Hospital, East York

M5G2C4

RECRUITING

University Health Network - Toronto General Hospital, East York

L8P1A2

RECRUITING

Hamilton Health Sciences - Hamilton General Hospital, Hamilton

K7L2V7

RECRUITING

Kingston Health Sciences Centre - Kingston General Hospital, Kingston

K1H8L6

RECRUITING

The Ottawa Hospital - Civic Campus, Ottawa

P6B 0A8

RECRUITING

Sault Area Hospital, Sault Ste. Marie

L2S 0A9

RECRUITING

Niagara Health - St. Catharines Site, St. Catharines

M1L 1W1

RECRUITING

Unity Health - St Michael's Hospital, Toronto

M4N3M5

RECRUITING

Sunnybrook Health Sciences Centre, Toronto

M5G1X5

RECRUITING

Sinai Heath System - Mount Sinai Hospital, Toronto

H3T1E2

RECRUITING

Jewish General Hospital, Montreal

H4A3J1

RECRUITING

McGill University Health Centre - Montral General Hospital, Montreal

J7Z5T3

RECRUITING

Hôpital Régional de Saint Jérôme, Saint-Jérôme

J1H 5H3

RECRUITING

University of Sherbrooke Health Centre - Hospital Fleurimont, Sherbrooke

272-0827

RECRUITING

Science Tokyo University Hospital, Ichikawa

0620

RECRUITING

North Shore Hospital, Takapuna

0148

NOT_YET_RECRUITING

Whangarei Hospital, Whangarei

All Listed Sponsors
collaborator

Berry Consultants

OTHER

collaborator

McGill University Health Centre/Research Institute of the McGill University Health Centre

OTHER

collaborator

Menzies School of Health Research

OTHER

collaborator

Aotearoa Clinical Trials

UNKNOWN

collaborator

Queensland University of Technology

OTHER

collaborator

Sunnybrook Health Sciences Centre

OTHER

collaborator

Tan Tock Seng Hospital

OTHER

collaborator

Telethon Kids Institute

OTHER

collaborator

The Peter Doherty Institute for Infection and Immunity

OTHER

collaborator

The University of Queensland

OTHER

collaborator

UMC Utrecht

OTHER

collaborator

Radboud University Medical Center

OTHER

collaborator

King's College London

OTHER

collaborator

Rambam Health Care Campus

OTHER

collaborator

University College, London

OTHER

collaborator

The Methodist Hospital Research Institute

OTHER

lead

University of Melbourne

OTHER