A Study to Examine the Effects of Novel Therapy Linvoseltamab in Combination With Other Cancer Treatments for Adult Patients With Multiple Myeloma That is Resistant to Current Standard of Care Treatments

PHASE1RecruitingINTERVENTIONAL
Enrollment

317

Participants

Timeline

Start Date

August 17, 2022

Primary Completion Date

April 11, 2028

Study Completion Date

September 26, 2034

Conditions
Multiple Myeloma
Interventions
DRUG

Linvoseltamab

Linvoseltamab is administered by intravenous (IV) infusion

DRUG

Daratumumab

Daratumumab is administered by IV infusion and/or subcutaneous (SC) injection; SC injection may be used after a minimum of 2 cycles of IV administration at the investigator's discretion.

DRUG

Carfilzomib

Carfilzomib is administered by IV infusion

DRUG

Lenalidomide

Lenalidomide is administered by mouth (PO) as a capsule

DRUG

Bortezomib

Bortezomib is administered by IV infusion or SC injection

DRUG

Pomalidomide

Pomalidomide is administered by mouth (PO) as a capsule

DRUG

Isatuximab

Isatuximab is administered by IV infusion

DRUG

Fianlimab

Fianlimab is administered by IV infusion

DRUG

Cemiplimab

Cemiplimab is administered by IV infusion

DRUG

Nirogacestat

Nirogacestat is administered by mouth (PO) as a tablet

DRUG

Cevostamab

Cevostamab is administered by IV infusion

Trial Locations (42)

10021

RECRUITING

Weill Cornell Medicine/New York Presbyterian Hospital, New York

10032

RECRUITING

New York Presbyterian Hospital Columbia University Medical Center, New York

10676

RECRUITING

Evangelismos General Hospital, Athens

11528

RECRUITING

General Hospital of Athens Alexandra, Athens

15706

RECRUITING

Hospital Clinico Universitario de Santiago, Santiago de Compostela

27157

RECRUITING

Wake Forest University Health Sciences, Winston-Salem

27599

RECRUITING

University of North Carolina at Chapel Hill, Chapel Hill

28006

RECRUITING

Universitaru Hospital La Princesa, Madrid

28027

RECRUITING

Clinica Universidad de Navarra - Madrid, Madrid

28034

RECRUITING

Hospital Universitario Ramon y Cajal - Servicio de Psiquiatria, Madrid

28041

RECRUITING

University Hospital and Research Institute, Madrid

28050

RECRUITING

Hospital Universitario HM Sanchinarro, Madrid

28223

RECRUITING

Hospital Universitario Quiron Salud Madrid, Pozuelo de Alarcón

30004

RECRUITING

Winship Cancer Institute of Emory University, Atlanta

31008

RECRUITING

Clinica Universidad de Navarra, Pamplona

34295

RECRUITING

CHU Montpellier - Departement D'Hematologie, Montpellier

37007

RECRUITING

University Hospital of Salamanca, Salamanca

39008

RECRUITING

Hospital Universitario Marques de Valdecilla, Santander

43210

RECRUITING

The Ohio State University James Cancer Hospital, Columbus

44093

RECRUITING

Nantes University Hospital, Nantes

46202

RECRUITING

Indiana University Health Simon Cancer Center, Indianapolis

48201

RECRUITING

Karmanos Cancer Institute, Detroit

49933

RECRUITING

Centre Hospitalier Universitaire Angers, Angers

55905

RECRUITING

Mayo Clinic, Rochester

59037

SUSPENDED

CHU de Lille - Rue Michel Polonovski, Lille

75010

RECRUITING

Saint Louis Hospital, Paris

75015

RECRUITING

Hopital Necker, Paris

75390

RECRUITING

University of Texas Southwestern, Dallas

75571

RECRUITING

Hopital Saint Antoine, Paris

86021

RECRUITING

Centre Hospitalier Universitaire (CHU) de Poitiers, Poitiers

91120

RECRUITING

Hadassah Medical Center, Jerusalem

92037

RECRUITING

Scripps Clinic Torrey Pines, La Jolla

94000

RECRUITING

Hospital Henri Mondor, Créteil

94805

RECRUITING

Institut Gustave Roussy, Villejuif

98108

RECRUITING

VA Puget Sound Health Care System, Seattle

3109601

RECRUITING

Rambam Health Care Campus, Haifa

5265601

RECRUITING

Sheba Medical Center, Ramat Gan

02215

RECRUITING

Dana Farber/Harvard Cancer Center, Boston

08916

RECRUITING

Hospital Germans Trias i Pujol, Badalona

08035

RECRUITING

Hospital Universitario Vall d'Hebron, Barcelona

08036

RECRUITING

Hospital Clinic de Barcelona, Barcelona

08908

RECRUITING

Institut Catala d'Oncologia (ICO) - Hospital Duran i Reynals,, Barcelona

All Listed Sponsors
lead

Regeneron Pharmaceuticals

INDUSTRY