Carotid Revascularization for Radiation Induced Carotid Artery Stenosis

RecruitingOBSERVATIONAL
Enrollment

150

Participants

Timeline

Start Date

January 5, 2020

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2027

Conditions
Radiation-induced Carotid Artery Stenosis
Interventions
PROCEDURE

Carotid endarterectomy (CEA)

Surgeons follow the contemporary guideline combined with their experience and preference in order to ultimately select what is best suited for the patient and choose between CEA and CAS. Patients will receive 100 mg of aspirin or 75 mg of clopidogrel daily starting from at least 72 h prior to the CEA procedure and continued receiving the medication indefinitely. General anesthesia is recommended for CEA, although the use of standard or eversion endarterectomy, and a shunt or patch, is left to the discretion of the surgeon.

PROCEDURE

Carotid artery stenting (CAS)

Surgeons follow the contemporary guideline combined with their experience and preference in order to ultimately select what is best suited for the patient and choose between CEA and CAS. Patients will be given 100 mg of aspirin plus 75 mg of clopidogrel daily for at least 3 days before the CAS procedure and for 90 days after the procedure. They will receive a daily dose of 100 mg aspirin or 75 mg clopidogrel thereafter. For the CAS procedure, local anaesthesia and predilation prior to stent placement are recommended. Use of an embolic protection device is mandatory for all patients who undergo CAS.

Trial Locations (2)

100005

RECRUITING

Xuanwu Hospital, Capital Medical University, Beijing

510080

RECRUITING

Guangdong Provincial People's Hospital, Guangzhou

All Listed Sponsors
collaborator

Guangdong Provincial People's Hospital

OTHER

lead

Xuanwu Hospital, Beijing

OTHER