A Study to Evaluate How Safe Pozelimab + Cemdisiran Combination Therapy is and How Well it Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have Not Recently Received or Have Not Received Complement Inhibitor Treatment

PHASE3RecruitingINTERVENTIONAL
Enrollment

190

Participants

Timeline

Start Date

August 1, 2022

Primary Completion Date

January 28, 2027

Study Completion Date

January 28, 2027

Conditions
Paroxysmal Nocturnal Hemoglobinuria
Interventions
DRUG

Ravulizumab

Administered Intravenous (IV) per the protocol

DRUG

Pozelimab

Administered IV and subcutaneous (SC) per the protocol

DRUG

Cemdisiran

Administered SC per the protocol

DRUG

Eculizumab

Administered IV per the protocol

Trial Locations (63)

114

RECRUITING

Tri-Service General Hospital, Taipei

704

RECRUITING

National Cheng Kung University Hospital, Tainan City

1011

RECRUITING

St Lukes Medical Center, Quezon

1083

RECRUITING

Semmelweis University, Budapest

4070

RECRUITING

Taichung Veterans General Hospital (VGHTC), Taichung

10126

RECRUITING

Hematology Citta della Salute e della Scienza di Torino, Turin

10330

RECRUITING

King Chulalongkorn Memorial Hospital, Bangkok

10400

WITHDRAWN

Rajavithi Hospital, Bangkok

11942

RECRUITING

Jordan University Hospital (JUH), Amman

15072

RECRUITING

Clinica San Felipe, Lima

16247

RECRUITING

St. Vincent Hospital, Suwon

16499

RECRUITING

Ajou University Medical Center, Suwon

21565

RECRUITING

Gachon University Gil Medical Center, Incheon

25200

RECRUITING

Hospital Tg Ampuan Afzan, Kuantan

30008

RECRUITING

Hospital General JM Morales Meseguer, Murcia

33305

RECRUITING

Chang Gung Memorial Hospital - Linkou Branch, Taoyuan District

34418

RECRUITING

Istanbul University, Istanbul

35100

RECRUITING

Ege University, Izmir

40000

RECRUITING

Srinagarind Hospital, Khon Kaen

40447

RECRUITING

China Medical University Hospital, Taichung

48013

RECRUITING

Hospital Universitario Basurto, Bilbao

49241

RECRUITING

Pusan National University Hospital, Busan

50139

RECRUITING

Aou Careggi, Florence

50200

RECRUITING

Chaing Mai University, Chiang Mai

57010

RECRUITING

George Papanikolaou Hospital, Thessaloniki

64460

RECRUITING

Servicio de Hematologia del Hospital Universitario de la Uanl, Monterrey

68000

RECRUITING

Hospital Ampang, Ampang

80756

RECRUITING

Kaohsiung Medical University Hospital, Kaohsiung City

88586

RECRUITING

Hospital Queen Elizabeth, Kota Kinabalu

90110

RECRUITING

Clinical Research Center, Faculty of Medicine, Prince of Songkla University, Hat Yai

90603

RECRUITING

The Oncology Institute of Hope & Innovation, Whittier

97002

RECRUITING

Hualien Tzu Chi Hospital, Hualien City

100032

COMPLETED

Peking Union Medical College Hospital, Beijing

100229

RECRUITING

National Taiwan University Hospital, Taipei

110085

RECRUITING

Rajiv Gandhi Cancer Institute & Research Center (RGCIRC) - Rohini Campus, New Delhi

119074

RECRUITING

National University Hospital, Singapore

200143

RECRUITING

Municipal Hospital Filantropia, Craiova

226003

RECRUITING

King George Hospital, Lucknow

302017

RECRUITING

Bhagwan Mahaveer Cancer Hospital and Research Centre (BMCHRC), Jaipur

400015

RECRUITING

Ion Chiricuta Oncology Institute, Cluj-Napoca

400022

RECRUITING

K J Somaiya Super Specialty Hospital & Research Centre, Mumbai

540136

RECRUITING

Targu Mures Clinical County Emergency Hospital, Târgu Mureş

670103

RECRUITING

Malabar Cancer Center, Kerala, Kannur

682041

RECRUITING

Amrita Institute of Medical Sciences (AIMS) and Research Centre Aims, Kochi

708248

RECRUITING

Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh

M5G2 C4

RECRUITING

Toronto General Hospital, Toronto

050034

RECRUITING

Hospital Pablo Tobon Uribe, Medellín

000168

RECRUITING

Fondazione Policlinico Universitrio a. Gemelli - IRCCS, Rome

466-8650

RECRUITING

Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya

503-8502

RECRUITING

Ogaki Municipal Hospital, Ōgaki

305-8576

RECRUITING

University of Tsukuba Hospital, Tsukuba

570-8540

RECRUITING

Matsushita Memorial Hospital, Moriguchi

141-8625

RECRUITING

NTT Medical Center Tokyo, Shinagawa-ku

80-214

RECRUITING

University Clinical Center Medical University of Gdansk, Gdansk

85-168

RECRUITING

Szpital Uniwersytecki Nr2 Bydgoszcz, Bydgoszcz

02-776

RECRUITING

Institute of Hematology and Transfusion Medicine, Warsaw

02841

RECRUITING

Korea University Hospital, Seoul

03722

RECRUITING

Severance Hospital, Seoul

06351

RECRUITING

Samsung Medical Center, Seoul

07985

RECRUITING

Ewha Womans University Mokdong Hospital, Seoul

08036

RECRUITING

Hospital Clinic de Barcelona, Barcelona

500-06

RECRUITING

Changhua Christian Hospital, Changhua

LS9 7TF

RECRUITING

St James Hospital, Leeds

All Listed Sponsors
lead

Regeneron Pharmaceuticals

INDUSTRY