A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer

National Taiwan University Hospital, Taipei

Koo Foundation Sun Yat-Sen Cancer Center, Taipei

Chang Gung Memorial Hospital LinKou, Taoyuan

National Cheng Kung University Hospital, Tainan City

Chi Mei Medical Center, Tainan City

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

Jules Bordet lnstituut, Anderlecht

Universitair Ziekenhuis Brussel (UZ Brussel), Brussels

Cliniques Universitaires Saint-Luc, Brussels

Clinique St-Pierre, Ottignies

Chris O'Brien Lifehouse, Camperdown

Macquarie University Clinical Trials Unit., Macquarie University

Western Sydney Local Health District (WSLHD), Westmead Hospital, Westmead

Austin Health, Heidelberg

Box Hill Hospital, Box Hill

Cancer Research SA, Adelaide

St Andrews Medical Centre, Adelaide

Flinders Medical Centre, Bedford Park

Kantonsspital Baden., Baden

St John of God Subiaco Hospital Clinical Trials Unit Bendat Family Comprehensive Cancer Centre, Subiaco

Brust-Zentrum AG, Zurich

Kantonsspital Winterthur, Winterthur

Hospital San Pedro de Alcantara, Cáceres

Charite Universtitatsmedizin Berlin Klinik fur Gynakologie mit Brustzentrum, Berlin

National Cancer Center, Goyang-si

MacKay Medical Foundation The Presbyterian Church in Taiwan MacKay Memorial Hospital, Taipei

Montefiore Einstein Comprehensive Cancer Center, The Bronx

Taipei Veterans General Hospital, Taipei

"General Hospital of Athens Alexandra Clinical Therapeutics Department, Hematology/Oncology Unit", Athens

Charite - Universitatsmedizin Berlin, Berlin

Seoul National University Bundang Hospital, Seongnam-si

Fakultni Thomayerova nemocnice Onkologicka klinika 1. LF UK a FTN, Praha 4 - Krc

Centre de Lutte contre le Cancer - François Baclesse, Caen

Fakultni nemocnice v Motole Onkologicka klinika 2. LF UK a FN Motol, Praha 5 - Motol

IASO General Clinic Oncology Clinic, Marousi

IRCCS Ospedale Policlinico, San Martino, Genoa

The Catholic University of Korea, St. Vincent's Hospital, Suwon

Ajou University Hospital, Suwon

Institut Catala d'Oncologia Girona - ICO Girona, Girona

Hospital Universitario Virgen de las Nieves, Granada

Metaxa Anticancer Hospital of Piraeus, Pireaus

Asplundh Cancer Pavillion, Willow Grove

Istituto Clinico Humanitas, Milan

Divisione di Senologia Medica; Istituto Europeo di Oncologia, Milan

Universitatsklinikum Hamburg-Eppendorf (UKE), Hamburg

ASST Monza Ospedale San Gerardo Centro Ricerca di Fase 1, Monza (MB)

Mercy Medical Center, Baltimore

Gachon University Gil Medical Center, Incheon

"CARIO - Centre Armoricain de Radiotherapie lmagerie medicate et d'Oncologie -Hopital Prive des", Plérin

CHU Besancon, Besançon

Hospital Universitari Arnau de Vilanova, Lleida

Yonsei University Wonju Severance Christian Hospital, Wŏnju

University General Hospital of Patras, Oncology Department, Internal Medicine Clinic, Patra

Istituti Clinici Scientifici Maugeri IRCCS, Pavia

Hospital General Universitario Gregorio Maranon, Madrid

Hospital Universitario Ramon y Cajal, Madrid

Chungbuk Nationl University Hospital, Cheongju-si

Hospital El Angel Grupo Hla, S.L.U, Málaga

Hospital Universitario Virgen De La Arrixaca, EI Palmar

Emory University Hospital Midtown, Atlanta

Emory University Clinic, Atlanta

Winship Cancer Institute, Atlanta

Emory Saint Joseph's Hospital, Atlanta

Mayo Clinic Florida, Jacksonville

AdventHealth Altamonte Infusion Center, Altamonte Springs

AdventHealth Medical Group Altamonte(second location), Altamonte Springs

AdventHealth Medical Group Altamonte, Altamonte Springs

AdventHealth Medical Group Orlando, Orlando

AdventHealth Orlando Infusion Center, Orlando

Institut Bergonie, Bordeaux

Tampere University Hospital, FONK/RSYO, Tampere

Centre de Cancérologie du Grand Montpellier, Montpellier

Institut Régional du Cancer de Montpellier, Montpellier

Hospital Universitario de Salamanca (Spain Salamanca), Salamanca

Tennessee Oncology, PLLC, Gallatin

Tennessee Oncology, PLLC, Murfreesboro

Tennessee Oncology, PLLC, Shelbyville

Sarah Cannon Research Institute- Pharmacy, Nashville

Tennessee Oncology, PLLC, Nashville

Divisione Oncologia Medica, Ospedale di Trento - Presidio Ospedaliero (PO) Santa Chiara, Trento

SOC Farmacia, Ospedale di Trento - Presidio Ospedaliero (PO), Trento

Hospital Universitario de Canarias, La Laguna Tenerife

Azienda Ospedaliero-Universitaria di Bologna Policlinico S. Orsola-Malpighi, Bologna

SSD Oncologia Medica Addarii - Zamagni, Policlinico Sant'Orsola - Malpighi, Bologna

Norton Cancer Institute - Downtown, Louisville

Norton Cancer Institute, Downtown, Louisville

Norton Cancer Institute, St Matthews Campus, Louisville

Norton Cancer Institute, Brownsboro Hospital Campus, Louisville

Hospital Universitario Virgen del Rocio, Seville

University General Hospital of Larissa, Oncology Clinic, Larissa

UOC di Oncologia Medica, Azienda Ospedaliero Universitaria (AOU) di Parma, Parma

Cleveland Clinic Taussig Cancer Center Investigational Pharmacy, Cleveland

Cleveland Clinic Cancer Center - Strongsville, Strongsville

Cleveland Clinic, Cleveland

Institut de Cancerologie de lOuest - Site Rene Gauducheau, Saint-Herblain

Institut de Cancerologie de lOuest-Saint Herblain, Saint-Herblain

Fundacion lnstituto Valenciano de Oncologia, Valencia

Hospital Clinico Universitario de Valencia, Valencia

Hospital Universitario de Basurto, Bilbao

University Hospital Muenster Senology, Münster

Dong-A University Hospital, Busan

Froedtert Hospital/Medical College of Wisconsin, Milwaukee

Mayo Clinic, Rochester

Oncologia Medica Azienda Usl Toscana Nord Ovest - Ospedali Riuniti di Livor, Livorno

S.O.C. Oncologia Medica - Nuovo Ospedale di Prato Santo Stefano, Prato

Azienda Ospedaliero Universitaria delle Marche SOD Clinica Oncologica, Torrette

University of Illinois Hospital and Health Systems (Investigational Drug Pharmacy), Chicago

University of Illinois Hospital and Health Systems (Outpatient Cancer Center), Chicago

University of Illinois Hospital and Health Systems, Chicago

Centre Jean Perrin, Clermont-Ferrand

Saint Luke's Cancer Institute., Kansas City

Institut de Cancerologie Strasbourg Europe, Strasbourg

Oncology Hematology West PC dba Nebraska Cancer Specialists, Papillion

Oncology Hematology West PC dba Nebraska Cancer Specialists, Omaha

Oncology Hematology West PC dba Nebraska Cancer Specialists, Omaha

Oncology Hematology West PC dba Nebraska Cancer Specialists, Omaha

Pharmacy:Fortuna Herstellung GmbH, Mannheim

Universitätsmedizin Mannheim Universitätsfrauenklinik, Manheim

Oncology Hematology West PC dba Nebraska Cancer Specialists, Grand Island

Oncology Hematology West, PC dba Nebraska Cancer Specialists - Grand Island, Grand Island

Hospices Civils de Lyon, Pierre-Bénite

Central Arkansas Radiation Therapy Institute Inc d.b.a CARTI, Little Rock

Centre Henri Becquerel / Centre Regional de Lutte Contre le Cancer, Rouen

Azienda Ospedaliera Universitaria Federico II, Napoli

lstituto Nazionale Tumori IRCCS - Fondazione Pascale U.O.C. Oncologia Medica Senologica, Napoli

Klinikum Rechts der Isar der Technischen Universitaet Muenchen, München

Institut Sainte-Catherine., Avignon

Mayo Clinic Hospital, Phoenix

Mayo Clinic, Scottsdale

"Universitatsklinikum Augsburg Klinik fur Frauenheilkunde und Geburtshilfe", Augsburg

Universitatsklinikum Ulm Klinik fur Frauenheilkunde und Geburtshilfe, Ulm

Administrative Address: UCLA Hematology/Oncology, Los Angeles

UCLA Hematology/Oncology, Los Angeles

UCLA Hematology/Oncology - Beverly Hills, Beverly Hills

UCLA Hematology/Oncology - Santa Monica, Santa Monica

UCLA Hematology/Oncology Parkside, Santa Monica

Clinical And Translational Research Center, Torrance

The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance

Harbor-UCLA Medical Center, Torrance

UCLA Hematology/Oncology - Santa Clarita, Valencia

UCLA Hematology/Oncology- Westlake, Westlake Village

UCLA Hematology/Oncology - Burbank, Burbank

UCSD Medical Center - Encinitas, Encinitas

Sulpizio Cardiovascular Center at UC San Diego Health, La Jolla

UC San Diego Medical Center - La Jolla (Jacobs Medical Center / Thornton Pavilion), La Jolla

UCSD Koman Family Outpatient Pavilion, La Jolla

UCSD Perlman Medical Offices, La Jolla

UCSD Medical Center - Vista, Vista

UC San Diego Moores Cancer Center, La Jolla

UC San Diego Medical Center - Hillcrest, San Diego

Institut Curie - site St-Cloud, Saint-Cloud

Institut Curie, Saint-Cloud

UCLA Hematology/Oncology - Laguna Hills, Laguna Hills

UCLA Hematology/Oncology- Santa Barbara, Santa Barbara

UCLA Hematology/Oncology - San Luis Obispo, San Luis Obispo

Humanitas lstituto Clinico Catanese, Catania (CT)

Universitatsklinikum Wurzburg Frauenklinik und Poliklinik, Würzburg

Universitatsklinikum Wurzburg, Comprehensive Cancer Center - Mainfranken (CCCMF), Würzburg

Fred Hutchinson Cancer Center, Seattle

University of Washington Medical Center, Seattle

Beijing Hospital, Beijing

The First Hospital of China Medical University, Shenyang

Liaoning Cancer Hospital & Insitute, Shenyang

The First Hospital of Jilin University, Changchun

Ruijin Hospital of Shanghai Jiaotong University School of Medicine, Shanghai

Fudan University Shanghai Cancer Center, Shanghai

Nanjing Medical University (NMU) - Jiangsu Province Hospital, Nanjing

The Second Hospital of Anhui Medical University, Hefei

Jinan Central Hospital, Jinan

Linyi Cancer Hospital, Linyi

Tianjin Medical University Cancer Institute & Hospital, Tianjin

Zhejiang Cancer Hospital, Hangzhou

Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou

The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou

The Second Affiliated Hospital of Nanchang University, Nanchang

The Second Xiangya Hospital of Central South University, Changsha

Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan

Hubei Cancer Hospital, Wuhan

Henan Cancer Hospital, Zhengzhou

Guangdong Provincial People's Hospital, Guangzhou

Meizhou People's Hospital, Meizhou

Guangxi Medical University Affiliated Tumor Hospital, Nanning

The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning

Liuzhou People's Hospital, Liuzhou

The first Affiliated Hospital of Hainan Medical University, Haikou

The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an

UCSD Medical Center - Bankers Hill, San Diego

Clinica Universidad Catolica del Maule, Talca

James Lind Centro De Investigacion Del Cancer, Temuco

RWJBarnabas Health- Jersey City Medical Center, Jersey City

RWJBarnabas Health- Monmouth Medical Center-Southern Campus, Lakewood

RWJBarnabas Health- Cooperman Barnabas Medical Center, Livingston

RWJBarnabas Health- Monmouth Medical Center, Long Branch

Rutgers Cancer Institute of New Jersey, New Brunswick

Newark Beth Israel Medical Center, Newark

RWJBarnabas Health-Robert Wood Johnson University Hospital, Somerset, Somerville

Steeplechase Cancer Center, Somerville

RWJBarnabas Health - Community Medical Center, Toms River

Satellite Infusion Center-Monmouth Medical Center Vantage Point Infusion Center, West Long Branch

Ordination Priv.-Doz. Dr. Michael Hubalek, Schwaz

Medizinische Universitat Graz, Graz

Ordensklinikum Linz GmbH Barmherzige Schwestern, Linz

Medizinische Universitat Wien Universitatsklinik Fur Frauenheilkunde, Vienna

CRIO - Centro Regional lntegrado de Oncologia, Fortaleza

Hospital Araujo Jorge, Goiânia

Hospital Do Cancer De Londrina, Londrina

Liga Norte-Rio Grandense Contra o Cancer, Natal

Hospital de Clinicas de Porto Alegre, Porto Alegre

Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa - Hospital do Cancer Mae de Deu, Porto Alegre

Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa - Hospital do Cancer Mae de Deu, Porto Alegre

Fundacao Pio XII, Hospital do Amor de Barretos, Barretos

Fundacao Dr Amaral Carvalho, Jaú

CEPHO- Centro de Estudos e Pesquisas de Hematologia e Oncologia, Santo André

CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia, Santo André

Irmandade da Santa Casa de Misericordia de Porto Alegre centro Multidisciplinar de pesquisa clinica, Porto Alegre/RS

Faculdade Regional de Medicina de Sao Jose do Rio Preto, São José do Rio Preto

ICESP- Instituto do Cancer do Estado de Sao Paulo Octavio Frias de Oliveira, São Paulo

Sao Camilo Oncologia, São Paulo

Clinica de Pesquisas e Centro de Estudos em Oncologia Ginecologica e Mamária Ltda., São Paulo

A.C. Camargo Câncer Center, São Paulo/SP

Cross Cancer Institute, Edmonton

BC Cancer Agency, Kelowna

The Ottawa Hospital Cancer Centre, Ottawa

Sunnybrook Research Institute, Toronto

Mount Sinai Hospital, Toronto

Centre integre universitaire de sante et de services sociaux du Saguenay-Lac-Saint-Jean, Chicoutimi

Centre Hospitalier de l'Universite de Motreal (CHUM), Montreal

Jewish General Hospital, Montreal

Oncocentro Apys, Viña del Mar

Centro de Investigacion Clínica Bradford Hill, Recoleta

Shaanxi Provincial People's Hospital, Xi'an

Affiliated Hospital of Hebei University, Baoding

Masarykuv Onkologicky Ustav, Brno

Ustavni lekarna Masarykuv onkologicky ustav, Brno

Vseobecna fakultni nemocnice v Praze, Prague

Hopital Avicenne, Bobigny

CENTRE FRANCOIS BACLESSE - Service lmagerie medicale, Caen

Center Georges-Francois Leclerc, Dijon

Centre Oscar Lambret, Lille

Center Leon Berard, Lyon

Institut Regional du Cancer de Montpellier Service lmagerie medicale, Montpellier

Centre Antoine Lacassagne, Nice

Centre Eugene Marquis, Rennes

Centre Henri Becquerel, Rouen

Tesshokai Kameda General Hospital, Kamogawa

National Cancer Center Hospital East, Kashiwa-Shi

NHO Shikoku Cancer Center, Matsuyama

National Hospital Organization Kyushu Cancer Center, Fukuoka

Fukushima Medical University Hospital, Fukushima

National Hospital Organization Hokkaido Cancer Center, Sapporo

Ishikawa Prefectural Central Hospital, Kanazawa

Kanagawa Cancer Center, Yokohama

University of Tsukuba Hospital, Tsukuba

Naha Nishi Clinic, Naha

Kindai University Hospital, Osakasayama-shi

National Cancer Center Hospital, Chuo-ku

St. Luke's International Hospital., Chuo-ku

Toranomon Hospital, Minato-ku

Showa University Hospital, Shinagawa-ku

Albert Schweitzer Hospital, Doedrecht

Albert Schweitzer Ziekenhuis, Dordrecht

St. Antonius Hospital, Utrecht

VieCuri Medsich Centrum, Venlo

Narodowy lnstytut Onkologii im. Marii Sklodowskiej-Curie-Panstwowy lnstytut Badawczy, Gliwice

Uniwersyteckie Centrum Kliniczne, Gdansk

Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi, Lodz

SP ZOZ Opolskie Centrum Onkologii im. Prof. Tadeusza Koszarowskiego w Opolu, Opole

Centro Clinico Academico Braga Hospital de Braga, Braga

Instituto Portugues de Oncologia de Coimbra Francisco Gentil, EPE (IPO, Coimbra), Coimbra

Fundacao Champalimaud, Lisbon

Hospital CUF Descobertas, Lisbon

Korea University Anam Hospital, Seoul

Seoul National University Hospital, Seoul

Severance Hospital Yonsei University Health System, Seoul

Asan Medical Center, Seoul

Gangnam Severance Hospital, Yonsei University Health System, Seoul

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

Ewha Womans University Mokdong Hospital, Seoul

Hospital Universitario Son Espases, Palma de Mallorca

Fundación Privada Instituto de Investigación Oncológica de Vall Hebron, Barcelona

Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca, Barcelona

Hospital Universitari Vall d'Hebron, Barcelona

Hospital General Universitario Alicante, Alicante

Hospital de la Santa Creu i Sant Pau, Barcelona

Changhua Christian Medical Foundation Changhua Christian Hospital, Changhua

Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare, New Taipei City

China Medical University Hospital, Taichung

Tri-Service General Hospital, Taipei

Academic Oncology, London

The Royal Marsden NHS Foundation Trust (Surrey), London

The Royal Marsden, Sutton

Finchley Memorial Hospital, London

University College London Hospital (UCLH) NHS Foundation Trust, London

The Royal Marsden, London

Christie Hospital NHS Foundation Trust, Manchester