Safety and Immunogenicity of the rVSVΔG-ZEBOV-GP Ebola Virus Vaccine Candidate in Children Living in Lambaréné, Gabon

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

April 9, 2021

Primary Completion Date

September 8, 2021

Study Completion Date

August 9, 2022

Conditions
Ebola Virus Disease
Interventions
BIOLOGICAL

rVSVΔG-ZEBOV-GP, V920

The experimental vaccine is the rVSVΔG-ZEBOV-GP, an Ebola vaccine.

DIETARY_SUPPLEMENT

Fibre and equilibrate breakfast and lunch

Participants receive fibres and caloric equilibrate diet during breakfast and lunch every day for 21 consecutive days.

DIAGNOSTIC_TEST

Active detection and treatment of pathogens

Monthly diagnostic and treatment of childhood infections Active detection and treatment of pathogens.

COMBINATION_PRODUCT

Fibre and equilibrate breakfast and lunch plus Active detection and treatment of pathogens

Participants receive fibres and caloric equilibrate diet during breakfast and lunch every day for 21 consecutive days and diagnostic and treatment of childhood infections Active detection and treatment of pathogens every month for 12 months

BIOLOGICAL

Chikenpox or Varicella vaccine (VARILRIX)

The active comparator vaccine, a Varicella vaccine (VARILRIX®)

OTHER

Placebo

About 30 children do not receive diet, nor active pathogen detection

Trial Locations (1)

242

Centre de Recherches Médicales de Lambaréné, Lambaréné

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Centre de Recherche Médicale de Lambaréné

OTHER