A Study to Evaluate the Safety and Efficacy of mRNA-1345 Vaccine Targeting Respiratory Syncytial Virus (RSV) in Adults ≥60 Years of Age

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

36,814

Participants

Timeline

Start Date

November 17, 2021

Primary Completion Date

July 28, 2025

Study Completion Date

July 28, 2025

Conditions
Respiratory Syncytial Virus
Interventions
DRUG

Placebo

0.9% sodium chloride (normal saline) injection

DRUG

mRNA-1345

Sterile liquid for injection

Trial Locations (269)

112

Taipei Veterans General Hospital, Taipei

333

Chang Gung Memorial Hospital, Linkou, Taoyuan

404

China Medical University Hospital - PPDS, Taichung

1010

New Zealand Clinical Research - Auckland, Auckland

Optimal Clinical Trials Ltd, Auckland

1204

Icddr,b Kamalapur Field Site, Dhaka

1426

Hospital Militar Central Cirujano Mayor Dr. Cosme Argerich, Ciudad Autónoma de BuenosAires

1500

Worthwhile Clinical Trials, Benoni

2100

Northern Beaches Clinical Research, Brookvale

2148

Paratus Clinical Research - Western Sydney - PPDS, Blacktown

2450

Northside Health, Coffs Harbour

2617

Paratus Clinical Research - Canberra - PPDS, Bruce

2650

Vaccinopolis, Edegem

3010

Lakeland Clinical Trials, Rotorua

3100

JHU-Projahnmo Sylhet site, Sylhet

3124

Emeritus Research - PPDS, Camberwell

3190

JHU-Projahnmo Zakiganj site, Zakiganj

3590

ANIMA Research Center, Diepenbeek

3600

Ziekenhuis Oost-Limburg, Genk

3640

icddr,b Matlab Health Research Center, Chāndpur

4006

Holdsworth House Medical Brisbane, Fortitude Valley

4170

Aliwal Shoal Medical Center, eMkhomazi

5101

Private Practice Dr Jean Benoit Martinot, Erpent

7011

Southern Clinical Trials - Tasman, Nelson

7130

AES - DRS - Synexus - Helderberg Clinical Research Centre, Somerset West

8023

Southern Clinical Trials Limited, Christchurch

10017

AES - DRS - Synexus Clinical Research US, Inc. - New York, New York

10108

Instituto de Investigación en Ciencias Médicas S.A., San José

10203

Hospital CIMA San Jose, San José

10530

Drug Trials America, Hartsdale

10903

Hospital Clínica Bíblica Sede Santa Ana, San José

12627

AES - DRS - Synexus Berlin Research Centre, Berlin

13057

Velocity Clinical Research - East Syracuse - PPDS, East Syracuse

13760

Velocity Clinical Research (Endwell - New York) - PPDS, Endwell

14584

Soon Chun Hyang University Hospital Bucheon, Gyeonggi-do

14609

Rochester Clinical Research, Inc, Rochester

19040

Hatboro Medical Associates - CCT - PPDS, Hatboro

19055

Klinische Forschung, Schwerin GmbH (KFGN), Schwerin

19107

DM Clinical Research - Philadelphia - ERN - PPDS, Philadelphia

20017

Washington Health Institute, Washington D.C.

20520

Turku Vaccine Research Clinic, Turku

20854

Velocity Clinical Research (Rockville - Maryland) - PPDS, Rockville

20877

CBH Health - CenExel CBH - PPDS, Gaithersburg

21401

Privia Medical Group, LLC - Annapolis - Javara - PPDS, Annapolis

22332

Inha University Hospital, Jung-gu

22711

Catholic Kwandong University International St. Mar, Incheon

23606

Health Research of Hampton Roads Inc., Newport News

23703

Velocity Clinical Research - Family Practice - Portsmouth - PPDS, Portsmouth

26426

Yonsei University Wonju Severance Christian Hospital, Wŏnju

27410

Triad Clinical Trials, Greensboro

28006

Hospital Universitario de La Princesa, Madrid

28046

Hospital Universitario La Paz - PPDS, Madrid

28100

Pori Vaccine Research Clinic, Pori

28303

Carolina Institute for Clinical Research - M3 WR, Fayetteville

28403

Trial Management Associates, LLC, Wilmington

30030

iResearch Atlanta, Decatur

30060

Drug Studies America - ClinEdge - PPDS, Marietta

30159

Klinische Forschung Hannover-Mitte GmbH, Hanover

30214

Javara, Inc./Privia Medical Group Georgia, LLC, Fayetteville

30269

Randomize Now -Commerce Dr, Peachtree City

30281

Clinical Research Atlanta - ERN-PPDS, Stockbridge

30328

Mount Vernon Clinical Research, LLC - M3 WR, Atlanta

30909

Masters of Clinical Research Inc, Augusta

31110

Investigacion en Salud y Metabolismo S.C., Chihuahua City

31406

Velocity Clinical Research (Savannah - Georgia) - PPDS, Savannah

31904

Centricity Research - Roswell - HyperCore - PPDS, Columbus

32003

Fleming Island Clinical Research Center, Fleming Island

32055

Multi-Specialty Research Associates, Inc. M3 WR, Lake City

32132

Velocity Clinical Research, New Smyrna Beach, Edgewater

32162

AES - DRS - Synexus Clinical Research US, Inc. - The Villages, Orlando

32216

Jacksonville Center for Clinical Research, Jacksonville

32751

Accel Research Sites - Maitland - ERN - PPDS, Maitland

32789

Clinical Site Partners - Winter Park - HyperCore -PPDS, Winter Park

33009

Velocity Clinical Research - Hallandale Beach - PPDS, Hallandale

33100

Tampere Vaccine Research Clinic, Tampere

33140

IMA Clinical Research - Manhattan - PPDS, Miami Beach

33176

Spotlight Research Center, LLC, Miami

33409

Palm Beach Research - ClinEdge - PPDS, West Palm Beach

33458

Health Awareness Inc, Port Saint Lucie

33614

Clinical Trials of Tampa, Tampa

33709

IMA Clinical Research - Saint Petersburg - PPDS, St. Petersburg

33781

AES - DRS - Synexus Clinical Research US, Inc. - St. Petersburg, St. Petersburg

34217

Hospital General 450, Durango

35015

Chungnam National University Hospital, Daejeon

35211

AES - DRS - Synexus Clinical Research US, Inc. - Birmingham, Birmingham

35216

Accel Research Site - Achieve - Birmingham, Birmingham

35802

AES - DRS - Optimal Research Alabama - Huntsville, Huntsville

35976

Lakeview Clinical Research, Guntersville

37203

Affinity Health - Nashville, Nashville

40383

Versailles Family Medicine - CCT - PPDS, Versailles

40705

Taichung Veterans General Hospital, Taichung

44280

Maria del rayo morfin otero, Guadalajara

45212

CTI Clinical Research, Cincinnati

45219

Velocity Clinical Research (Cincinnati - Ohio) - PPDS, Cincinnati

Velocity Clinical Research - Cincinnati - PPDS, Cincinnati

45236

AES - DRS - Synexus Clinical Research US, Inc. - Cincinnati, Cincinnati

45355

Medizentrum Essen Borbeck, Essen

46025

FISABIO Oftalmología Médica (FOM), Valencia

46383

Velocity Clinical Research - Valparaiso - PPDS, Valparaiso

47714

AES - DRS - Synexus Clinical Research US, Inc. - Evansville, Evansville

48075

Great Lakes Research Institute, Southfield

48076

DM Clinical Research - Southfield - ERN - PPDS, Southfield

49201

Dong-A University Hospital, Busan

50101

Campus Universidad EARTH, finca La Flor, Liberia

55402

Clinical Research Institute, Inc - CRN - PPDS, Minneapolis

55423

AES - DRS - Synexus Clinical Research US, Inc. - Minneapolis, Richfield

57049

Velocity Clinical Research (Dakota Dunes - South Dakota) - PPDS, Dakota Dunes

57701

American Indian Clinical Trials Research Network, Rapid City

59804

Montana Medical Research, Missoula

59808

Boeson Research MSO - Missoula - ERN - PPDS, Missoula

60100

Seinäjoki Vaccine Research Clinic, Seinäjoki

60305

DM Clinical - Chicago, River Forest

60313

AES - DRS - Synexus Frankfurt Research Centre, Frankfurt am Main

60523

Affinity Health (Oak Brook), Oak Brook

60569

Infektioresearch GmbH & Co. KG, Frankfurt am Main

60602

AES - DRS - Synexus Clinical Research US, Inc. - Chicago, Chicago

63141

AES - DRS - Synexus Clinical Research US, Inc. - St. Louis, Creve Coeur

64000

Accelerium, S. de R.L. de C.V., Monterrey

66219

Johnson County Clin-Trials, Lenexa

67100

KokkolaVaccine Research Clinic, Kokkola

68022

Skyline Medical Center, PC - CCT Research, Elkhorn

68025

Methodist Physicians Clinic - CCT Research - PPDS, Fremont

68046

CCT Research, Papillion

68134

Velocity Clinical Research (Omaha - Nebraska) - PPDS, Omaha

68510

Velocity Clinical Research (Lincoln - Nebraska) - PPDS, Lincoln

68803

Velocity Clinical Research (Grand Island - Nebraska) - PPDS, Grand Island

70006

Benchmark Research - Metairie - HyperCore - PPDS, Metairie

70115

DelRicht Clinical Research, LLC - Internal - Covington - PPDS, New Orleans

70433

Benchmark Research - Covington - HyperCore - PPDS, Covington

70809

Velocity Clinical Research (Baton Rouge - Louisiana) - PPDS, Baton Rouge

71259

IMA Clinical Research - Monroe, LA - PPDS, Monroe

72205

Baptist Health Center for Clinical Research, Little Rock

73013

Tekton Research - Oklahoma - PPDS, Edmond

73099

Tekton Research, Yukon

75010

ACRC Trials - Carrollton - Hunt - PPDS, Carrollton

75033

Village Health Partners Frisco Medical Village, Frisco

75093

AIM Trials, Plano

76100

PanAmerican Clinical Research-Avenida, Querétaro

76132

Privia Medical Group- North Texas - West Parker Road - Fort Worth - Javara - PPDS, Fort Worth

76248

Helios CR, Inc. - Houston - PPDS, Keller

76401

Privia Medical Group- North Texas - Stephenville - Javara - PPDS, Stephenville

77055

West Houston Clinical Research - Hunt - PPDS, Houston

77081

DM Clinical Research - Bellaire - ERN - PPDS, Houston

77338

DM Clinical-TCDD, Humble

DM Clinical Research - Sugarland - ERN - PPDS, Sugar Land

77375

DM Clinical Research - ERN - PPDS, Tomball

DM Clinical Research - ERN, Tomball

77546

Allure Health LLC, Friendswood

Olympus Family Medicine- CCT, Friendswood

78229

AES - DRS - Synexus Clinical Research US, Inc. - San Antonio, San Antonio

Clinical Trials of Texas, LLC - HyperCore - PPDS, San Antonio

78520

PanAmerican Clinical Research LLC, Brownsville

78735

Premier Family Physicians - Austin - Hunt - PPDS, Austin

78745

Tekton Research, Austin

80012

Lynn Institute of Denver, Aurora

80020

Institucion Clinica de la Costa SAS, Barranquilla

80033

Paradigm Clinical Research Institute Inc - ClinEdge - PPDS, Wheat Ridge

80501

Tekton Research - Longmont - PPDS, Longmont

80525

Tekton Research - Fort Collins - PPDS, Fort Collins

83642

Velocity Clinical Research - Boise - PPDS, Meridian

84010

Cope Family Medicine - CCT - PPDS, Bountiful

84015

Alpine Research Organization, Inc, Clinton

84405

South Ogden Family Medicine - CCT, South Ogden

85018

Hope Research Institute LLC - Phoenix - Hunt - PPDS, Phoenix

85020

AES - DRS - Synexus Clinical Research US, Inc. - Phoenix Central, Phoenix

85023

Hope Research Institute LLC - Hunt - PPDS, Hunt

85213

Desert Clinical Research, LLC - CCT, Mesa

85224

Synexus Clinical Research US, Inc. - Phoenix Southeast, Phoenix

85284

Hope Research Institute LLC - Hunt - PPDS, Hunt

85710

Tucson Neuroscience Research - M3 WR, Tucson

89102

HEALOR Primary Care - Physicians Las Vegas - CCT, Las Vegas

89109

Excel Clinical Research - Las Vegas, Las Vegas

90220

Oulu Vaccine Research Clinic, Oulu

90230

PPD Virtual - Science 37, Inc, Culver City

90720

PRI, LLC - Los Alamitos - M3 WR, Los Alamitos

91303

Hope Clinical Research, LLC, Canoga Park

91768

Reddy Care Medical, Pomona

91911

Velocity Clinical Research - Chula Vista - PPDS, Chula Vista

91942

Velocity Clinical Research, San Diego, La Mesa

92220

Velocity Clinical Research, Banning, Banning

92660

PRI, LLC - Newport Beach - M3 WR, Newport Beach

Medical Center For Clinical Research - M3 WR, San Diego

93030

FOMAT Medical Research - FOMAT - HyperCore - PPDS, Oxnard

96001

Paradigm Clinical Research Institute Inc - ClinEdge - PPDS, Redding

96814

East West Medical Research Institute, Honolulu

97210

Summit Research Network, Inc. - Portland - Headlands - PPDS, Portland

98057

Rainier Clinical Research Center, Renton

98105

Seattle Clinical Research Center, Seattle

110221

Solano & Terront Servicios Médicos LTDA (UNIENDO) Bogota, Bogota

111611

Centro de Atención e Investigación Médica S.A. - CAIMED - Bogota, Bogota

169608

Singapore General Hospital (SGH), Singapore

250001

Centro de Atención e Investigación Médica S.A. - CAIMED - Chia, Chía

252431

Centro de Atención e Investigación Médica S.A. - CAIMED - Girardot, Girardot City

660003

IPS Centro de Investigacion Clinicas Cardiomet, Pereira

681002

Fundacion Oftalmologica de Santander Foscal, Floridablanca

730001

Centro de Atención e Investigación Médica S.A. - CAIMED - Ibague, Ibagué

760042

Centro Medico Imbanaco de Cali S.A., Santiago de Cali

856010

Centro de Atención e Investigación Médica S.A. - CAIMED - Aguazul, Aguazul

2260734

Centro Respiratorio Integral LTDA. (CENRESIN), Quillota

3465586

Centro de Investigacion del Maule, Talca

5311523

Hospital Base de Osorno, Osorno

7500710

Biomedica Research Group, Santiago

8320000

BIOCINETIC SpA, Santiago

06460

Clinical Research Consultants LLC - ClinEdge - PPDS, Milford

08869

IMA Clinical Research - Raritan - PPDS, Raritan

07094

Riverside Medical Group - Circuit - PPDS, Secaucus

B1900AVG

Instituto Medico Platense, Buenos Aires

C1023

Fundación Dr. Mario Socolinsky - Centro de Vacunación Proteger, Ciudad Autónoma de BuenosAires

C1425

Centro Medico Barrio Parque, Ciudad Autónoma de BuenosAires

C1426ABP

Consultorios Médicos Dr. Doreski, Ciudad Autónoma de BuenosAires

T4P 1K4

CARe Clinic, Red Deer

V1Y 1Z9

Okanagan Clinical Trials - Headlands - PPDS, Kelowna

M9W 4L6

Centricity Research - Toronto - HyperCore - PPDS, Etobicoke

L8J OB6

Dr. Steven Z. Zizzo Medicine Professional Corporation, Hamilton

M4G 3E8

LMC Clinical Research Inc (Bayview), Toronto

G6W OM5

Centricity Research - Quebec - HyperCore - PPDS, Lévis

J6E 2B4

Diex Recherche - Joilette - PPDS, Saint-Charles-Borromée

Diex Recherche - Québec - PPDS, Québec

J1L 0H8

Diex Recherche - Sherbrooke - PPDS, Sherbrooke

G9A 4P3

Diex Recherche - Trois Rivieres - PPDS, Trois-Rivières

02230

Espoo Vaccine Research Clinic, Espoo

00100

Helsinki South Vaccine Research Clinic, Helsinki

00930

Helsinki East Vaccine Research Clinic, Helsinki

04400

Järvenpää Vaccine Research Clinic, Järvenpää

910-0067

Fukui General Clinic, Fukui-shi

810-0021

Tenjin Sogo Clinic, Fukuoka

812-0025

Boocs Clinic Fukuoka, Hakata-ku

SOUSEIKAI PS Clinic, Fukuoka

231-0023

Motomachi Takatsuka Naika Clinic, Naka-ku, Yokohama-ku

104-0031

Medical Corporation Asbo Tokyo Asbo Clinic, Chuo-ku

162-8655

Center Hospital of the National Center for Global Health and Medicine, Shinjuku-ku

169-0072

Higashi Shinjuku Clinic, Shinjuku-ku

168-0065

NewHeart Watanabe Institute, Suginami-ku

171-0014

Sekino Hospital, Toshima-ku

03100

AES - AS - RM Pharma Specialists Mexico City, Ciudad de Mexcio

06100

AES - AS - CEMDEC Mexico City, Ciudad de Mexcio

0626

Southern Clinical Trials Waitemata, Auckland

07093

CEVAXIN Avenida México, Panama City

07113

CEVAXIN 24 de diciembre, Panama City

60-702

AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Poznaniu, Poznan

50-381

AES - DRS - Synexus Polska Sp. z o.o. Oddzial we Wroclawiu, Wroclaw

02-672

AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Warszawie, Warsaw

80-382

AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Gdansku, Gdansk

40-040

AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Katowicach, Katowice

27-400

Ostrowieckie Centrum Medyczne Spólka Cywilna Anna Olech-Cudzik, Krzysztof Cudzik, Ostrowiec Świętokrzyski

00717

BRCR Global Puerto Rico (Ponce), Ponce

00918

Caribbean Medical Research Center, San Juan

00935

Proyecto ACTU, San Juan

0002

Dr. J Breedt, Pretoria

0184

AES - DRS - Synexus - Stanza Clinical Research Centre, Pretoria

AES - DRS - Synexus Watermeyer Clinical Research Centre, Pretoria

06351

Samsung Medical Center - PPDS, Gangnam-gu

07804

Ewha Womans University Seoul Hospital, Gangseo-gu

03722

Severance Hospital Yonsei University Health System, Seoul

06273

Gangnam Severance Hospital, Yonsei University Health System, Seoul

07441

Hallym University Kangnam Sacred Heart Hospital, Seoul

08540

ABS Centelles, Centelles

07198

Hospital Son Llatzer, Son Ferriol

BS2 8HW

Bristol Royal Infirmary, Bristol

PR7 7NA

AES - DRS - NW Consortium Lancashire, Chorley

NE46 1QJ

AES - DRS - Synexus Hexham Clinical Research Centre, Hexham

ST10 1NS

Cheadle Hospital, Stoke-on-Trent

NE1 4LP

Royal Victoria Infirmary, Newcastle upon Tyne

ML4 3NJ

AES - DRS - Synexus Scotland Clinical Research Centre, Bellshill

B15 2SQ

AES - DRS - Synexus Midlands Clinical Research Centre, Birmingham

FY3 7EN

Layton Medical Centre, Blackpool

CF15 9SS

AES - DRS - Synexus Wales Clinical Research Centre, Cardiff

L22 0LG

AES - DRS - NW Consortium Merseyside, Liverpool

M15 6SE

AES - DRS - NW Consortium Manchester, Manchester

All Listed Sponsors
lead

ModernaTX, Inc.

INDUSTRY

NCT05127434 - A Study to Evaluate the Safety and Efficacy of mRNA-1345 Vaccine Targeting Respiratory Syncytial Virus (RSV) in Adults ≥60 Years of Age | Biotech Hunter | Biotech Hunter