The Efficacy of WVI in Patients With Localized Basal Ganglia Intracranial Germ Cell Tumors

PHASE2RecruitingINTERVENTIONAL
Enrollment

150

Participants

Timeline

Start Date

September 15, 2021

Primary Completion Date

October 31, 2026

Study Completion Date

October 31, 2026

Conditions
Intracranial Germ Cell CNS Tumor, Childhood
Interventions
RADIATION

Whole-ventricle irradiation

Whole-ventricle irradiation will be applied in patients with localized basal ganglia germ cell tumors after induction chemotherapy

DRUG

Carboplatin/etoposide

Carboplatin/etoposide regimen is applied as induction chemotherapy in patients with basal ganglia germinoma

DRUG

Ifosfamide/cisplatin/etoposide

Ifosfamide/cisplatin/etoposide regimen is applied as induction chemotherapy in patients with basal ganglia non-germinomatous germ cell tumors.

PROCEDURE

Second-look surgery

Second-look surgery would be applied to patients who presented residue disease after induction chemotherapy.

Trial Locations (1)

100070

RECRUITING

Beijing Tiantan Hospital, Beijing

All Listed Sponsors
lead

Beijing Tiantan Hospital

OTHER