6,700
Participants
Start Date
August 8, 2022
Primary Completion Date
July 31, 2026
Study Completion Date
September 30, 2026
Standardized seizure protocol
The intervention is a standardized seizure protocol for paramedics that prioritizes administration of only intramuscular (IM) or intranasal (IN) midazolam, up to 2 doses given 5 minutes apart, with age-based dosing as follows: 6-16 months (1.25 mg); 17 months-5 years (2.5 mg); 6-11 years (5 mg); 12-13 years (10 mg).
Conventional seizure protocol
"The control is the EMS agency's current seizure protocol, based on conventional calculation-based dosing. These vary from one EMS agency to the other with respect to recommended midazolam doses ranging from 0.05-0.3 mg/kg and with multiple route choices listed, including intravenous, intraosseous, intramuscular, intranasal, and rectal.~for paramedics that prioritizes administration of only intramuscular (IM) or intranasal (IN) midazolam, up to 2 doses given 5 minutes apart, with age-based dosing as follows: 6-16 months (1.25 mg); 17 months-5 years (2.5 mg); 6-11 years (5 mg); 12-13 years (10 mg)."
RECRUITING
University at Buffalo, Buffalo
RECRUITING
University of Pittsburgh, Pittsburgh
RECRUITING
Children's National Hospital, Washington D.C.
RECRUITING
Mecklenburg EMS, Charlotte
RECRUITING
Emory University, Atlanta
RECRUITING
Nationwide Children's Hospital, Columbus
RECRUITING
Cincinnati Children's Hospital Medical Center, Cincinnati
RECRUITING
Indiana University, Indianapolis
RECRUITING
University of Michigan, Ann Arbor
RECRUITING
Medical College of Wisconsin, Milwaukee
RECRUITING
University of Texas Southwestern, Dallas
RECRUITING
Baylor College of Medicine, Houston
RECRUITING
University of Colorado, Aurora
RECRUITING
University of Utah, Salt Lake City
RECRUITING
University of Arizona, Tucson
RECRUITING
Children's Hospital of Los Angeles, Los Angeles
RECRUITING
University of California, San Francisco, San Francisco
RECRUITING
University of California, Davis, Sacramento
RECRUITING
Oregon Health and Sciences University, Portland
RECRUITING
University of Washington, Seattle
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
University of Utah
OTHER
Baylor College of Medicine
OTHER
Stanford University
OTHER