EUS vs TJ for Liver Biopsy and Portal Pressure Gradient Measurement

NAActive, not recruitingINTERVENTIONAL
Enrollment

58

Participants

Timeline

Start Date

November 4, 2021

Primary Completion Date

December 1, 2024

Study Completion Date

January 1, 2025

Conditions
Portal HypertensionChronic Liver DiseaseCirrhosis
Interventions
PROCEDURE

Transjugular hepatic venous pressure gradient measurement with liver biopsy

This procedure will be performed by an experienced interventional radiologist who will be supported by a radiology technician and nurse. Transjugular hepatic venous pressure gradient measurement will be performed using standard procedure. Following this, a transjugular liver biopsy will be obtained using an 18-gauge transjugular liver biopsy needle.

PROCEDURE

Endoscopic ultrasound portal pressure gradient measurement with liver biopsy

A linear echoendoscope is inserted with the patient under conscious sedation. Using a through the scope 25-gauge needle connected to a digital manometer, portal and hepatic veins will be punctured under EUS guidance from a trans-gastric/hepatic approach. Following this, EUS-Liver biopsy is then performed immediately following EUS-PPG using a 19-gauge fine needle biopsy (FNB).

Trial Locations (1)

H3G1A4

McGill University Health Centre, Montreal

All Listed Sponsors
lead

McGill University Health Centre/Research Institute of the McGill University Health Centre

OTHER