Pembrolizumab/Placebo Plus Paclitaxel With or Without Bevacizumab for Platinum-resistant Recurrent Ovarian Cancer (MK-3475-B96/KEYNOTE-B96/ENGOT-ov65)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

643

Participants

Timeline

Start Date

December 13, 2021

Primary Completion Date

March 5, 2025

Study Completion Date

October 25, 2028

Conditions
Ovarian CancerCarcinoma, Ovarian EpithelialFallopian Tube Neoplasms
Interventions
BIOLOGICAL

Pembrolizumab

IV infusion

DRUG

Paclitaxel

IV infusion

DRUG

Bevacizumab

IV infusion

OTHER

Placebo for pembrolizumab

IV infusion

DRUG

Docetaxel

IV infusion

Trial Locations (187)

1000

Institut Jules Bordet-Medicine Oncology ( Site 0302), Brussels

1023

Auckland City Hospital ( Site 1901), Auckland

2145

Westmead Hospital-Department of Gynaecological Oncology ( Site 0201), Westmead

3000

UZ Leuven ( Site 0303), Leuven

3002

Epworth Freemasons ( Site 0204), Melbourne

4120

Gallipoli Medical Research Foundation-GMRF CTU ( Site 0202), Brisbane

6008

St. John of God Subiaco Hospital ( Site 0203), Subiaco

8500

AZ Groeninge Campus Kennedylaan-Oncology ( Site 0305), Kortrijk

9000

UZ Gent-Medical oncology ( Site 0301), Ghent

Aalborg Universitetshospital, Syd ( Site 0901), Aalborg

9038

Universitetssykehuset Nord-Norge HF-Kreftavdelingen ( Site 2001), Tromsø

10032

Columbia University Medical Center ( Site 0010), New York

10128

Ospedale Mauriziano-Ginecologia e Ostetricia ( Site 1507), Turin

13353

Charité Campus Virchow-Klinikum ( Site 1201), Berlin

14070

INSTITUTO NACIONAL DE CANCEROLOGIA ( Site 1701), Mexico City

14076

Centre François Baclesse-Recherche clinique ( Site 2904), Caen

14263

Roswell Park Cancer Institute ( Site 0039), Buffalo

15219

University of Pittsburgh Medical Center Magee-Womens Hospital ( Site 0024), Pittsburgh

20133

Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 1503), Milan

20141

Istituto Europeo di Oncologia IRCCS-Divisione di Ginecologia Oncologica ( Site 1502), Milan

20162

ASST Grande Ospedale Metropolitano Niguarda ( Site 1505), Milan

20521

Turku University Hospital-Department of Obstetrics and Gynecology ( Site 1001), Turku

20900

Ospedale San Gerardo-ASST Monza-Oncologia ( Site 1508), Monza

21202

Mercy Medical Center - Baltimore-Medical Oncology and Hematology ( Site 0015), Baltimore

22031

Inova Schar Cancer Institute ( Site 0019), Fairfax

22307

Asklepios Kliniken Hamburg-Asklepios Klinik Barmbek ( Site 1214), Hamburg

23040

Investigación Oncofarmacéutica-Investigación clínica ( Site 1706), La Paz

25123

Azienda Ospedaliera Spedali Civili di Brescia ( Site 1504), Brescia

27103

Novant Health Forsyth Medical Center ( Site 0057), Winston-Salem

27710

Duke Cancer Institute ( Site 0038), Durham

28204

Novant Health Presbyterian Medical Center ( Site 0029), Charlotte

29200

Centre Hospitalier Régional Universitaire de Brest - Hôpital-Institut de cancérologie et hématologi, Brest

30060

Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital-Research ( Site 0005), Marietta

32610

University of Florida College of Medicine-UF Health Cancer Center/Clinical Trials Office ( Site 0054, Gainesville

33612

Moffitt Cancer Center ( Site 0033), Tampa

34070

Centre de Cancérologie du Grand Montpellier ( Site 2908), Montpellier

34093

Bezmialem Vakf Üniversitesi-Oncology ( Site 2705), Istanbul

34098

Istanbul Universitesi Cerrahpasa ( Site 2709), Fatih

34180

Baskent Universitesi Ankara Hastanesi ( Site 2707), Ankara

34239

Sarasota Memorial Hospital ( Site 0018), Sarasota

34440

T.C. Saglik Bakanligi Turkiye Kamu Hastaneleri Kurumu - Bakirkoy Dr. Sadi Konuk Egitim ve Arastirma, Istanbul

35042

Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer-Medical Oncology ( Site 2901), Rennes

35100

Ege University Medicine of Faculty ( Site 2702), Bornova

38138

The West Clinic, PLLC dba West Cancer Center ( Site 0058), Germantown

40138

IRCCS - AOU di Bologna-SSD Oncologia medica Addarii ( Site 1501), Bologna

40225

Universitaetsklinikum Duesseldorf-Klinik für Frauenheilkunde & Geburtshilfe ( Site 1204), Düsseldorf

41017

Saint Elizabeth Medical Center Edgewood-Cancer Care Center ( Site 0040), Edgewood

44109

MetroHealth Medical Center-Cancer Care Center ( Site 0047), Cleveland

44277

Hôpital privé du Confluent SAS-Service d'oncologie médicale ( Site 2905), Nantes

44710

Aultman Hospital-Oncology Clinical Trials ( Site 0009), Canton

46260

St. Vincent Hospital and Health Care Center, Inc ( Site 0032), Indianapolis

46845

Parkview Research Center at Parkview Regional Medical Center ( Site 0027), Fort Wayne

47805

Zentrum fuer ambulante gynaekologische Onkologie (ZAGO) ( Site 1207), Krefeld

49100

Rabin Medical Center ( Site 1401), Petah Tikva

53127

Universitätsklinikum Bonn-Gynaecological oncology ( Site 1203), Bonn

57104

Sanford Cancer Center ( Site 0064), Sioux Falls

60068

Advocate Medical Group-Oncology ( Site 0049), Park Ridge

64710

iCan Oncology Center Centro Medico AVE ( Site 1704), Monterrey

66113

CaritasKlinikum Saarbrücken St. Theresia ( Site 1211), Saarbrücken

68020

Centro de Investigacion Clinica de Oaxaca ( Site 1705), Oaxaca City

71103

WK Physicians Network / Hematology Oncology Associates ( Site 0034), Shreveport

75231

Texas Oncology - Dallas (Presbyterian) ( Site 0065), Dallas

76001

Hemato Oncologos SA ( Site 0801), Santiago de Cali

77380

Texas Oncology - The Woodlands_Lee ( Site 0043), The Woodlands

85016

HonorHealth ( Site 0041), Phoenix

87042

Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren-oncologie ( Site 2907), Limoges

91054

Universitaetsklinikum Erlangen-Klinik für Gynäkologie und Geburtshilfe ( Site 1205), Erlangen

92210

Institut Curie - site Saint-Cloud ( Site 2909), Saint-Cloud

92270

Eisenhower Medical Center ( Site 0067), Rancho Mirage

93940

Pacific Cancer Care ( Site 0028), Monterey

94904

Marin Cancer Care ( Site 0055), Greenbrae

97213

Providence Portland Medical Center ( Site 0048), Portland

100142

Beijing Cancer hospital ( Site 0711), Beijing

100730

Beijing Peking Union Medical College Hospital-Gynecological center of tumor ( Site 0702), Beijing

111221

Clínica Universitaria Colombia ( Site 0806), Bogotá

115478

"Fed State Budgetary Inst N.N. Blokhin Med Center of Oncology MHRF-Chemotherapy #2 ( Site 2211)", Moscow

130021

The First Hospital of Jilin University ( Site 0710), Changchun

143423

Moscow City Oncology Hospital #62 ( Site 2214), Krasnogorsk D-t

200011

Obstetrics & Gynecology Hospital of Fudan University ( Site 0715), Shanghai

200032

Fudan University Shanghai Cancer Center-Gynecologic Oncology Department ( Site 0701), Shanghai

201204

Shanghai First Maternity and Infant Hospital-Gynecology department ( Site 0744), Shanghai

210000

Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Oncology (, Nanjing

230001

Anhui Provincial Hospital-Obstetrics and Gynecology ( Site 0709), Hefei

250117

Shandong Cancer Hospital-Oncology Department ( Site 0733), Jinan

276001

LinYi Cancer Hospital ( Site 0731), Linyi

300052

Tianjin Central Hosptial of Gynecology Obstetrics ( Site 0737), Tianjin

300060

Tianjin Medical University Cancer Institute and Hospital ( Site 0720), Tianjin

325000

The First Affiliated Hospital of Wenzhou Medical University-Gynecology ( Site 0706), Wenzhou

330006

Jiangxi Maternal and Child Health Hospital-Oncology Department ( Site 0716), Nanchang

350014

Fujian Provincial Cancer Hospital ( Site 0713), Fuzhou

410008

Xiangya Hospital Central South University-Gynecology ( Site 0705), Changsha

410013

Hunan Cancer Hospital ( Site 0704), Changsha

430005

Ogarev Mordovia State University ( Site 2209), Saransk

430022

Wuhan Union Hospital-Medical Oncology ( Site 0735), Wuhan

430079

Hubei Cancer Hospital-Hubei Cancer Hospital ( Site 0708), Wuhan

450008

Henan Cancer Hospital ( Site 0718), Zhengzhou

454087

Chelyabinsk Regional Clinical Oncology Dispensary-Chelyabinsk Regional Clinical Oncology Dispensary, Chelyabinsk

510280

Zhujiang Hospital ( Site 0739), Guangzhou

524004

Affiliated Hospital of Guangdong Medical University ( Site 0743), Zhanjiang

530021

Guangxi Medical University Affiliated Tumor Hospital ( Site 0717), Nanning

570311

Hainan General Hospital ( Site 0736), Haikou

610066

West China Second University Hospital Sichuan University ( Site 0740), Chengdu

620905

SVERDLOVSK REGIONAL ONCOLOGY DISPENSARY-Oncogynecology Department ( Site 2216), Yekaterinburg

650106

Yunnan Province Cancer Hospital-Gynecology Department ( Site 0714), Kunming

660001

Oncologos del Occidente ( Site 0807), Pereira

730030

Lanzhou university second hospital ( Site 0734), Lanzhou

1834111

Emek Medical Center-Gyn-Onc ( Site 1406), Afula

3100000

The Affiliated Women's Hospital of Zhejiang University-Obstetrics and Gynecology ( Site 0741), Hangzhou

3109601

Rambam Health Care Campus-Gyneco-oncology unit ( Site 1402), Haifa

4780000

James Lind Centro de Investigación del Cáncer ( Site 0602), Temuco

4810148

CIDO SpA-Oncology ( Site 0608), Temuco

5265601

Sheba Medical Center ( Site 1407), Ramat Gan

5500243

Clínica Puerto Montt ( Site 0601), Port Montt

6423906

Sourasky Medical Center ( Site 1403), Tel Aviv

7510032

Oncovida ( Site 0603), Santiago

7630370

Instituto de Radiomedicina-hemato-oncologia ( Site 0604), Santiago

8241479

Clínica Vespucio-Hemato - Ocology ( Site 0607), Santiago

8330032

Pontificia Universidad Catolica de Chile-Centro del Cáncer ( Site 0609), Santiago

8410101

Soroka Medical Center ( Site 1404), Beersheba

8420383

Bradfordhill ( Site 0605), Santiago

9103102

Shaare Zedek Medical Center ( Site 1405), Jerusalem

88501001

ANIMI - Unidade de Tratamento Oncologico ( Site 0408), Lages

06511

Yale-New Haven Hospital-Smilow Cancer Hospital at Yale-New Haven ( Site 0004), New Haven

01605

University of Massachusetts Chan Medical School-Division of Gynecologic Oncology ( Site 0003), Worcester

07601

John Theurer Cancer Center at Hackensack University Medical Center ( Site 0007), Hackensack

74605-070

Hospital Araújo Jorge ( Site 0401), Goiânia

59075-740

Liga Norte Riograndense Contra o Câncer-Centro de Pesquisa Clínica ( Site 0404), Natal

01323-001

BP - A Beneficencia Portuguesa de São Paulo ( Site 0403), São Paulo

04014-002

Núcleo de Pesquisa Clínica da Rede São Camilo ( Site 0405), São Paulo

20220-410

Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA-Pesquisa Clinica HC II ( Site 0402), Rio de Janeiro

T2N 4N2

Tom Baker Cancer Center ( Site 0511), Calgary

V2S 0C2

BC Cancer Abbotsford ( Site 0512), Abbotsford

V8R 6V5

BC Cancer Victoria ( Site 0513), Victoria

K7L 2V7

Kingston Health Sciences Centre-Kingston General Hospital Si-Oncology and/or Hematology - Gynecolog, Kingston

M4N 3M5

Sunnybrook Health Sciences - Odette Cancer Centre ( Site 0508), Toronto

H1T 2M4

CIUSSS de l'Est-de-l'Île-de-Montréal ( Site 0501), Montreal

H3T 1E2

Jewish General Hospital ( Site 0505), Montreal

H4A 3J1

McGill University Health Centre ( Site 0502), Montreal

G1J 1Z4

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0, Québec

S7N 4H4

Saskatoon Cancer Center ( Site 0510), Saskatoon

Unknown

Zhongda Hospital Southeast University ( Site 0723), Nanjing

Leicester Royal Infirmary-HOPE Clinical Trials Unit ( Site 2812), Leicester

050030

Fundación Colombiana de Cancerología Clínica Vida ( Site 0808), Medellín

080020

Clinica de la Costa LTDA-Clinical Research Oncology & Hematology -Pediatric ( Site 0809), Barranquilla

01307

Universitaetsklinikum Carl Gustav Carus Dresden-Klinik und Poliklinik für Frauenheilkunde und Gebur, Dresden

04103

Universitätsklinikum Leipzig-Department of Gynecology and Obstetrics ( Site 1213), Leipzig

D08 E9P6

St. James's Hospital-Cancer clinical trials office ( Site 2821), Dublin

464-8681

Aichi Cancer Center Hospital ( Site 1610), Nagoya

277-8577

National Cancer Center Hospital East ( Site 1609), Kashiwa

791-0280

National Hospital Organization Shikoku Cancer Center ( Site 1603), Matsuyama

791-0295

Ehime University Hospital ( Site 1606), Tōon

830-0011

Kurume University Hospital ( Site 1607), Kurume

060-8648

Hokkaido University Hospital ( Site 1604), Sapporo

028-3695

Iwate Medical University Hospital ( Site 1613), Shiwa-gun Yahaba-cho

211-8533

Nippon Medical School Musashi Kosugi Hospital ( Site 1614), Kawasaki

350-1200

Saitama Medical University International Medical Center ( Site 1601), Hidaka-shi

411-8777

Shizuoka Cancer Center ( Site 1611), Nakatogari

104-0045

National Cancer Center Hospital ( Site 1612), Chuo-ku

135-8550

Japanese Foundation for Cancer Research ( Site 1605), Koto

541-8567

Osaka International Cancer Institute ( Site 1602), Osaka

04700

COI Centro Oncologico Internacional S.A.P.I. de C.V.-Investigation Unit COI ( Site 1703), Mexico City

6525 GA

Radboudumc ( Site 1802), Nijmegen

2333 ZA

Leids Universitair Medisch Centrum-Medical Oncology ( Site 1801), Leiden

3015 GD

Erasmus Medisch Centrum-Medical Oncology ( Site 1803), Rotterdam

3584 CX

Universitair Medisch Centrum Utrecht-Medical Oncology ( Site 1804), Utrecht

61-848

Szpital Kliniczny im. Heliodora Święcickiego Uniwersytetu Me-Oddzial Ginekologii Onkologicznej ( Sit, Poznan

00-315

Szpital Kliniczny im. Księżnej Anny Mazowieckiej ( Site 2103), Warsaw

02-781

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Gynecological Oncology Department ( Sit, Warsaw

15-027

Bialostockie Centrum Onkologii-Oddzial Onkologii Ginekologicznej ( Site 2106), Bialystok

15-276

Uniwersytecki Szpital Kliniczny w Bialymstoku-Uniwersyteckie Centrum Onkologii ( Site 2104), Bialystok

80-214

Uniwersyteckie Centrum Kliniczne-Klinika Ginekologii, Ginekologii Onkologicznej i Endokrynologii Gi, Gdansk

44-101

Narodowy Instytut Onkologii - Oddzial w Gliwicach-III Klinika Radioterapii i Chemioterapii ( Site 21, Gliwice

25-734

Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zaklad Opieki Zdrowotnej ( Site 2107), Kielce

03080

Seoul National University Hospital ( Site 2302), Seoul

03722

Severance Hospital, Yonsei University Health System-Gynecologic cancer center ( Site 2303), Seoul

05505

Asan Medical Center-Division of Gynecologic Oncology, Dept. of Obstetrics & Gynecology ( Site 2304), Seoul

06273

Gangnam Severance Hospital ( Site 2301), Seoul

01250

cukurova universty ( Site 2706), Sarçam

Baskent University Dr. Turgut Noyan Research and Training Center-ONCOLOGY ( Site 2704), Adana

06100

Ankara University Hospital Cebeci ( Site 2701), Ankara

BN2 5BE

Brighton and Sussex University Hospitals NHS Trust ( Site 2803), East Sussex

CB2 2QQ

Addenbrooke's Hospital ( Site 2808), Cambridge

TR1 3LJ

The Royal Cornwall Hospital ( Site 2804), Truro

LA9 7RG

Westmorland General Hospital ( Site 2815), Kendal

DD1 9SY

Ninewells Hospital and Medical School ( Site 2826), Dundee

W12 0HS

Hammersmith Hospital-Medical Oncology ( Site 2818), London

CF14 2TL

Velindre Cancer Centre ( Site 2805), Cardiff

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY