Trastuzumab Deruxtecan (T-DXd) Alone or in Sequence With THP, Versus Standard Treatment (ddAC-THP), in HER2-positive Early Breast Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

927

Participants

Timeline

Start Date

October 25, 2021

Primary Completion Date

March 12, 2025

Study Completion Date

April 30, 2027

Conditions
Breast NeoplasmsBreast CancerHER2-positive Early Breast Cancer
Interventions
DRUG

Trastuzumab Deruxtecan

administered by intravenous infusion

DRUG

Paclitaxel

administered by intravenous infusion

DRUG

Trastuzumab

administered by intravenous infusion

DRUG

Pertuzumab

administered by intravenous infusion

DRUG

Doxorubicin

administered by intravenous infusion

DRUG

cyclophosphamide

administered by intravenous infusion

Trial Locations (146)

100

Research Site, Taipei

114

Research Site, Taipei

333

Research Site, Taoyuan District

710

Research Site, Tainan City

1112

Research Site, Quezon City

1330

Research Site, Sofia

3354

Research Site, Riyadh

4103

Research Site, Leipzig

4500

Research Site, Panagyurishte

5000

Research Site, Iloilo City

6000

Research Site, Cebu City

6100

Research Site, Bacolod

8000

Research Site, Davao City

10060

Research Site, Candiolo

10117

Research Site, Berlin

10210

Research Site, Bangkok

10330

Research Site, Bangkok

10400

Research Site, Bangkok

10408

Research Site, Goyang-si

11217

Research Site, Taipei

11426

Research Site, Riyadh

11725

Research Site, Commack

15033

Research Site, Lima

20089

Research Site, Rozzano

20132

Research Site, Milan

20357

Research Site, Hamburg

21423

Research Site, Jeddah

23214

Research Site, Jeddah

24105

Research Site, Kiel

27710

Research Site, Durham

28007

Research Site, Madrid

28040

Research Site, Madrid

29607

Research Site, Greenville

31444

Research Site, Dammam

33098

Research Site, Paderborn

35128

Research Site, Padua

36312

Research Site, Vigo

37024

Research Site, Negrar

37203

Research Site, Nashville

38138

Research Site, Germantown

40002

Research Site, Khon Kaen

40138

Research Site, Bologna

40202

Research Site, Louisville

40443

Research Site, Taichung

40503

Research Site, Lexington

41013

Research Site, Seville

41061

Research Site, Mönchengladbach

46804

Research Site, Fort Wayne

48149

Research Site, Münster

50200

Research Site, Chiang Mai

55407

Research Site, Minneapolis

57100

Research Site, Livorno

69120

Research Site, Heidelberg

71101

Research Site, Shreveport

72076

Research Site, Tübingen

72762

Research Site, Springdale

76104

Research Site, Fort Worth

80131

Research Site, Naples

Research Site, Napoli

81377

Research Site, München

82445

Research Site, Kaohsiung City

84405

Research Site, Ogden

86156

Research Site, Augsburg

89102

Research Site, Las Vegas

90110

Research Site, Hat Yai

90211

Research Site, Beverly Hills

90720

Research Site, Los Alamitos

91054

Research Site, Erlangen

91204

Research Site, Glendale

92868

Research Site, Orange

98405

Research Site, Tacoma

100039

Research Site, Beijing

110001

Research Site, Shenyang

110029

Research Site, New Delhi

117997

Research Site, Moscow

122001

Research Site, Gūrgaon

143423

Research Site, Moscow

190020

Research Site, Saint Petersburg

197758

Research Site, Saint Petersburg

200032

Research Site, Shanghai

249203

Research Site, Rishikesh

266100

Research Site, Qingdao

300060

Research Site, Tianjin

395002

Research Site, Surat

400030

Research Site, Chongqing

410008

Research Site, Changsha

410013

Research Site, Changsha

422002

Research Site, Nashik

430060

Research Site, Wuhan

430079

Research Site, Wuhan

440001

Research Site, Nagpur

450008

Research Site, Zhengzhou

492001

Research Site, Raipur

510060

Research Site, Guangzhou

510080

Research Site, Guangzhou

510700

Research Site, Guangzhou

530021

Research Site, Nanning

650118

Research Site, Kunming

695011

Research Site, Thiruvananthapuram

711103

Research Site, Howrah

06510

Research Site, New Haven

08816

Research Site, East Brunswick

07901

Research Site, Summit

74000-000

Research Site, Goiânia

98700-000

Research Site, Ijuí

59075-740

Research Site, Natal

90610-000

Research Site, Porto Alegre

91350-200

Research Site, Porto Alegre

01221-020

Research Site, São Paulo

01229-010

Research Site, São Paulo

T6G 1Z2

Research Site, Edmonton

M5G 1X5

Research Site, Toronto

H4A-3J1

Research Site, Montreal

G1S 4L8

Research Site, Québec

J1H 5N4

Research Site, Sherbrooke

H3T 1E2

Research Site, Montreal

110 085

Research Site, New Delhi

00168

Research Site, Roma

104-8560

Research Site, Chūōku

862-8655

Research Site, Chūōku

350-1298

Research Site, Hidaka-shi

734-8551

Research Site, Hiroshima

216-8511

Research Site, Kawasaki-shi

135-8550

Research Site, Kōtoku

466-8560

Research Site, Nagoya

467-0001

Research Site, Nagoya

373-8550

Research Site, Ota-shi

162-8655

Research Site, Shinjuku-ku

LIMA 29

Research Site, Lima

Lima 32

Research Site, Lima

LIMA 34

Research Site, Lima

Unknown

Research Site, San Juan City

15-027

Research Site, Bialystok

21-500

Research Site, Biała Podlaska

85-796

Research Site, Bydgoszcz

75-581

Research Site, Koszalin

20-090

Research Site, Lublin

30-055

Research Site, Rzeszów

02-781

Research Site, Warsaw

03080

Research Site, Seoul

03722

Research Site, Seoul

05505

Research Site, Seoul

06273

Research Site, Seoul

06351

Research Site, Seoul

08028

Research Site, Barcelona

08035

Research Site, Barcelona

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Daiichi Sankyo

INDUSTRY

lead

AstraZeneca

INDUSTRY